4,4’-Dimethoxytrityl Chloride 4,4’-双甲氧基三苯甲基氯
CAS 40615-36-9 MFCD00008409
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- {SA} Chemical Synthesis, Others, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents
- {SNA} Chemical Synthesis, Other Protecting and Derivatizing Reagents, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents
- {SNA} Chemical Synthesis, Others, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents
- {SNA} Bioactive Small Molecules, Cell Biology, Chemical Synthesis, DIG-DY, Others, Protecting and Derivatizing Reagents, Protection and Derivatization, Synthetic Reagents
产品应用
- 羟基保护试剂
相关文献及参考
- For selective protection and deprotection procedures for SH and OH groups in nucleoside derivatives, see: Synlett, 83 (1993).
- Beilstein: 6,H,1042
- In a comparison with Mmt for N-protection during solid-phase peptide synthesis, the N-Mmt group was found to survive intact whereas N-Dmt derivatives decomposed slowly in protic solvents: Tetrahedron. Lett., 39, 1733 (1998).
- Selective cleavage in acid-sensitive nucleosides and nucleotides without competing N-glycosyl cleavage has also been accomplished by the use of 1,1,1,3,3,3-Hexafluoro-2-propanol, A12747: Tetrahedron Lett., 36, 7833 (1995). For deprotection with montmorillonite K 10 clay, see: J. Org. Chem., 61, 9026 (1996).
- Reagent for protection of alcohols, compare Chlorotriphenylmethane, A11799 as their dimethoxytrityl (Dmt) ethers. Mono-, di- and trimethoxytrityl chlorides form ethers of increasing acid-lability, each MeO group increasing the rate of cleavage by ca x10: J. Am. Chem. Soc., 84, 430 (1962); 85, 3821 (1963). The group is introduced e.g. by reaction with the alcohol in pyridine solution. For use of DMAP as catalyst, see: J. Am. Chem. Soc., 104, 1316 (1982), or of silver nitrate: Can. J. Chem., 60, 1106 (1982).
安全信息
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S37 Wear suitable gloves 戴适当手套;
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- H315 Causes skin irritation 会刺激皮肤
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P302+P352+P332+P313+P362+P364
- P332+P313
- P305+P351+P338+P337+P313
- P302+P350
- P337+P313
- P305+P351+P338
GHS Symbol