2,6-Lutidine 2,6-二甲基吡啶

CAS 108-48-5 MFCD00006345

化学结构图

108-48-5
SMILES: Cc1cccc(C)n1

化学属性

Mol. FormulaC7H9N
Mol. Weight107
Density0.92
Refractive index1.4960 to 1.4990
Boiling Point143-145
Melting Point-6
Flash Point33°C(lit.)
TSCAYes
Solubility微溶于热水，溶于乙醇、乙醚。
pH:A

别名和识别编码

Chemical Name2,6-Lutidine
CAS Number108-48-5
Synonym 2,6-Dimethylpyridine a,a'-Dimethylpyridine a,a'-Lutidine α,α'-Dimethylpyridine
MDL NumberMFCD00006345
EC Number203-587-3
Beilstein Registry Number105690
PubChem Substance ID87572032
Merck Number5616
Chemical Name Translation2,6-二甲基吡啶
Reaxys-RN105690
LabNetwork Molecule IDLN00199608
InChIInChI=1S/C7H9N/c1-6-4-3-5-7(2)8-6/h3-5H,1-2H3
信息真实价格透明    资金保障    专业采购外包团队在线服务   
信息真实价格透明    资金保障    专业采购外包团队在线服务   
品牌质保精细包装    现货库存    一流品牌服务   

分类

  • {SNA} All Alphabetically Sorted, Analytical Standards, Analytical/Chromatography, Chemical Class, Chromatography, Flavors and Fragrances, Food & Beverage Standards, Food Products & Beverages, G-L, Grains, Life Sciences Standards, Natural Compounds, Natural Terpene Standards, Pyridine, Rice, Substance Classification
  • {SNA} A-D, Alphabetical Listings, C-D, Flavors and Fragrances, Halal Certified Products, Kosher Certified Products
  • {SNA} A - D, A-D, Alphabetical Listings, C-D, Flavors an

产品应用

  • 用于合成各种治疗高血压病的药及急救药，另外还用作杀虫剂及助染剂

相关文献及参考

  • Merck:14,5616 Beilstein:20(3/4)2776
  • Short: II/24C
  • Base catalyst for the silylation of highly-hindered secondary or tertiary alcohols by tert-Butyl­dimethyl­silyl­ trifluoromethanesulfonate, A12174.
  • Merck:14,5616
  • This hindered base has been recommended for the exhaustive methylation of aromatic amines: J. Org. Chem., 35, 1558 (1970), and for the Rosenmund reduction of acyl halides to aldehydes: Synthesis, 767 (1976).
  • Van den Dool, H., et al.: J. Chromatogr.,11, 463 ( 1963), Radulovic, N., et al.: Phytother. Res., 20, 85 (2006),
  • For monometallation with potassium amide in liquid ammonia, and subsequent carboethoxylation with diethyl carbonate, see: Org. Synth. Coll., 6, 611 (1988).
  • Short: II/24B

安全信息

Signal word Warning
GHS Symbol
WGK Germany3
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
  • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾；
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36 Wear suitable protective clothing 穿戴适当的防护服；
  • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
Risk Statements
  • R10 Flammable 易燃
  • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
  • R22 Harmful if swallowed 吞咽有害
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P241+P242+P243
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P301+P312+P330
  • P302+P352+P332+P313+P362+P364
  • P305+P351+P338
  • P305+P351+P338+P337+P313
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
  • P332+P313
  • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
  • P370+P378
  • P403+P235
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H302 Harmful if swallowed 吞食有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECSOK9700000
Packing GroupIII
UN Number 1993
Hazard Codes 3 Xn,F,Xi
Storage condition -20°C Hygroscopic
Hazard Class3
Warnings 危化品目录(2015) 
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,845,1986

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7500 ppm/1H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,845,1986

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 400 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,
   Prague, Czechoslovakia, Avicenum, 1986  Volume(issue)/page/year: -,845,1986

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 5000 ppm
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 163,23,1986

Restrict 危险品

其他信息

  • 急性毒性:口服- 大鼠 LD50: 400 毫克/ 公斤
  • Hazard Note:Irritant/Flammable
  • 图谱信息:2,6-二甲基吡啶(108-48-5)核磁图( 1 HNMR) 2,6-二甲基吡啶(108-48-5)Raman光谱 2,6-二甲基吡啶(108-48-5)核磁图( 13 CNMR) 2,6-二甲基吡啶(108-48-5)质谱(MS) 2,6-二甲基吡啶(108-48-5)红外图谱(IR1)
  • 用途三:用于合成各种治疗高血压病的药及急救药，另外还用作杀虫剂及助染剂。
  • 上游原料:乙醇 --> 乙醚 --> 硫酸 --> 硝酸 --> 氢氧化钾 --> 氢氧化铵 --> 氨 --> 甲醛 --> 乙酰乙酸乙酯 --> 无水氯化钙 --> 二乙胺 --> 氧化钙 --> 3-甲基吡啶
  • 灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
  • 检测方法:GC,NMR
  • 可燃性危险特性:遇明火、高温、氧化剂较易燃; 遇热产生有毒氧化氮气体
  • 食品添加剂最大允许使用量最大允许残留量标准:添加剂中文名称 允许使用该种添加剂的食品中文名称 添加剂功能 最大允许使用量（g/kg） 最大允许残留量（g/kg） 2，6-二甲基吡啶 食品 食品用香料 用于配制香精的各香料成分不得超过在GB 276
  • TCI Shanghai:2,6-二甲基吡啶 2,6-Lutidine,>;98.0%(GC)(108-48-5)
  • 2,6-二甲基吡啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 K6276002 2.6-二甲基吡啶 500ml 1050元 2011/08/23 L0571702 2,6-二甲基吡啶, 98+% 100ml 200元 2011/08/23 SL390003 2,6-二甲基吡啶 500ml 820元
  • 类别:易燃液体
  • 方法一:可通过从煤炼焦副产物中回收β-甲基吡啶馏分中分离得到。
  • 有特臭，微溶于热水，溶于乙醇、乙醚。
  • 用途二:该品在有机合成中用途广泛。医药工业中可用于生产抗动脉粥样硬化药血脉宁。还可用于生产对蛔虫、布氏姜片虫、鞭虫、蛲虫等有效的广谱驱虫药驱蛲净。以及可的松乙酸酯、氢化可的松、烟酸、芦别林等等。2,6-二甲基吡啶还可用作农药、染料、印染助剂、树脂、橡胶硫化促进剂、热油安定剂的中间体。本品经氧化可得到二甲基吡啶酸，用作过氧化氢和过乙酸的稳定剂，还能合成山梗碱。该品也可用作溶剂。
  • MSDS 信息:2,6-二甲基吡啶(108-48-5).msds
  • 用途一:用作有机合成原料
  • 外观性质:无色、油状液体, 有特臭。
  • MOL 文件:108-48-5.mol
  • FEMA:3540
  • Sigma Aldrich:108-48-5(sigmaaldrich)
  • 毒性分级:高毒
  • F:8
  • 储运特性:库房通风低温干燥; 与氧化剂、酸类分开存放
  • 下游产品:佛手苷内酯 --> 5-溴-1,2,3,4-四氢异喹啉 --> 3,5-二甲基-4-氨基吡啶 --> 7-溴-1,2,3,4-四氢异喹啉 --> 吡啶-2,6-二甲酸 --> 2,4-二甲基吡啶 --> 头孢匹胺 --> 2-溴甲基-6-甲基吡啶 --> 2,6-吡啶二甲醇 --> 2,6-二甲基吡啶 N-氧化物 --> 3-氨基-2,6-二甲基吡啶 --> 2,6-二甲基-3-溴吡啶 --> 2,6-二甲基-3-硝基吡啶 --> 2,6-双（氯甲基）吡啶
  • Acros Organics:2,6-二甲基吡啶（99%） 2,6-Lutidine, 99%(108-48-5)
  • Alfa Aesar:2,6-二甲基吡啶,98+% 2,6-Lutidine, 98+%(108-48-5)
  • 海关编码:29333999

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Acids - Synthetic Reagents
  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Organic Bases - Synthetic Reagents
  1. Application Areas 应用领域分类
  2. Flavors and Fragrances 香精香料
  3. Kosher Certified Products - Flavors and Fragrances
  4. A-D - Kosher Certified Products
  1. Application Areas 应用领域分类
  2. Flavors and Fragrances 香精香料
  3. Alphabetical Listings - Flavors and Fragrances
  4. C-D - Alphabetical Listings
  1. C8 to C9 - Pyridines
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Natural Compounds - Life Sciences Standards
  1. Analytical & Chromatography 分析化学与色谱
  2. Analytical Standards
  3. Chromatography - Analytical Standards
  4. Life Sciences Standards - Chromatography
  5. Natural Compounds - Life Sciences Standards
  1. Life Science 生命科学
  2. Biochemicals and Reagents 生化试剂
  3. Lipids - Biochemicals and Reagents
  4. Fatty Acyls - Lipids
  5. Fatty Esters - Fatty Acyls
  6. Others - Fatty Esters
  1. C6
  1. Life Science 生命科学
  2. Biochemicals and Reagents
  3. Lipids
  4. Fatty Acids
  5. Saturated fatty acids and derivatives
  6. Dicarboxylic acids
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Heterocyclic Building Blocks 杂环合成砌块
  4. Pyridines 吡啶