CAS 79-07-2 MFCD00008027-Chloroacetamide 氯乙酰胺 TAO{mole}

Chloroacetamide 氯乙酰胺

CAS 79-07-2 MFCD00008027

化学结构图

SMILES: NC(=O)CCl

化学属性

Mol. Formula	C2H4ClNO
Mol. Weight	93.51
Density	1.268
Vapor Pressure	0.05 mmHg ( 20 °C)
Melting Point	116-118°C
Flash Point	170°C
TSCA	Yes
Boiling Point	225°C(lit.)
Appearance	白色晶体。能溶于10倍的水和10倍的无水乙醇。极微溶于乙醚。
Solubility	能溶于10倍的水和10倍的无水乙醇，极微溶于乙醚。

别名和识别编码

Chemical Name	Chloroacetamide
CAS Number	79-07-2
Alfabeta Name	CHLOROACETAMIDE
MDL Number	MFCD00008027
Synonym	2-Chloroacetamide {LY} 2-Chloroacetamide {} {LY} 2-Chloroacetamide {} {} {LY} 2-Chloroacetamide {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Chloroacetamide {} {} {} {} {} {} {} {} {} {} {} {}
EC Number	201-174-2
Beilstein Registry Number	878191
PubChem Substance ID	6580
Merck Number	2110
Chemical Name Translation	氯乙酰胺
Reaxys-RN	878191
Wiswesser Line Notation	ZV1G
LabNetwork Molecule ID	LN00176711
InChI	InChI=1S/C2H4ClNO/c3-1-2(4)5/h1H2,(H2,4,5)
Canonical SMILES	O=C(N)CCl

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产品应用

用于合成羧酰氨基甲酯（作为肽合成中的羧基保护基）的试剂

安全信息

Warnings IRRITANT

Signal word

GHS Symbol

WGK Germany2

Safety Statements

S22 Do not breathe dust 不要吸入粉尘；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R25 Toxic if swallowed 吞咽有毒
R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P301+P310
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P501 Dispose of contents/container to..… 处理内容物/容器.....
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P305+P351+P338
P201 Obtain special instructions before use. 使用前获取专门指示。
P308+P313
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P302+P350
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P302+P352+P333+P313+P362+P364
P330 Rinse mouth. 漱口
P333+P313

Hazard statements

H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H301 Toxic if swallowed 吞食有毒

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

RTECSAB5075000

Packing GroupIII

UN Number UN 2811 6.1/PG 3

Hazard Codes T

Hazard Class6.1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD277

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 70 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 19,1073,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 180 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#03764

TYPE OF TEST

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 155 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CHHTAT Zhonghua Yixue Zazhi.  Chinese Medical Journal.  (China International
   Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1-    1915-   
   Suspended 1967-72.  Volume(issue)/page/year: 58,462,1978

TYP

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 2 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 210,255,1989

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

防护措施:本品有刺激性及腐蚀性。能刺激皮肤及粘膜。车间应通风良好，生产设备应密闭。操作人员应穿戴防护用具（如防护目镜、口罩、手套等）。
氯乙酰胺价格(试剂级):更新日期产品编号产品名称包装价格 2011/08/23 30037926 2-氯乙酰胺;氯乙酰胺 100g 48元 2011/04/16 C0086 2-氯乙酰胺 2-Chloroacetamide 25G 124元 2011/04/16 C0086 2-氯乙酰胺 2-Chloroacetamide 500G 437元
下游产品:L-天门冬氨酸 --> 氯乙腈 --> 丁草胺 --> 硝西泮 --> 2-氯-5-甲氧基苯硼酸 --> 2-碘乙酰胺 --> 氟乙酰胺 --> 氯乙酰异氰酸酯
用途二:用于有机合成，医药中间体以及合成氯乙腈、磺胺-3-甲氧基吡嗪、磺胺甲基吡嗪等有机化合物。
海关编码:29241900
急性毒性:口服-大鼠 LD50: 138 毫克/公斤; 口服-小鼠 LD50: 155 毫克/公斤
储运特性:库房低温通风干燥; 与食品原料分开存放
Acros Organics:2-氯乙酰胺 2-Chloroacetamide, 98%(79-07-2)
常规方法:内衬塑料袋，外用木箱或纸板桶包装。贮于阴凉、通风、干燥处。防晒、防潮。按刺激性物质规定贮运。
MOL 文件:79-07-2.mol
类别:有毒物质
Alfa Aesar:2-氯乙酰胺,98+% 2-Chloroacetamide, 98+%(79-07-2)
蒸气压:0.05 mm Hg ( 20 °C)
灭火剂:水,二氧化碳, 泡沫, 干粉
上游原料:氯化铵 --> 氯乙酸乙酯
可燃性危险特性:热分解排出有毒氮氧化物, 氯化物烟雾
毒性分级:高毒
能溶于10倍的水和10倍的无水乙醇，极微溶于乙醚。
Sigma Aldrich:79-07-2(sigmaaldrich)
用途一:用于合成氯乙腈、磺胺甲基吡嗪等有机化合物
TCI Shanghai:2-氯乙酰胺 2-Chloroacetamide,>;97.0%(T)(79-07-2)
方法一:由氯乙酸乙酯与氨反应而得。先将氯乙酸乙酯冷却至10℃以下，在搅拌下慢慢加入氨水（相对密度0.9），立即析出白色结晶，加完氨水后继续搅拌1h，过滤出结晶，再用氨水洗去氯化铵，尽量滤干即为粗品，再用乙醇重结晶而得成品。
图谱信息:氯乙酰胺(79-07-2)红外图谱(IR2) 氯乙酰胺(79-07-2)质谱(MS) 氯乙酰胺(79-07-2)红外图谱(IR1)
MSDS 信息:2-Chloroacetamide(79-07-2).msds