CAS 156-43-4 MFCD00007865-p-Phenetidine 对乙氧基苯胺 TAO{mole}

p-Phenetidine 对乙氧基苯胺

CAS 156-43-4 MFCD00007865

化学结构图

SMILES: CCOc1ccc(N)cc1

化学属性

Mol. Formula	C8H11NO
Mol. Weight	137.18
Density	1.065
Refractive index	1.5600 to 1.5630
Boiling Point	-
Melting Point	N/A
Flash Point	115.56°C
TSCA	Yes
Solubility	不溶于水，溶于乙醇。
Stability	对光线敏感;对空气敏感
pH	:A

别名和识别编码

Chemical Name	p-Phenetidine
CAS Number	156-43-4
Alfabeta Name	ETHOXYANILINE 4-
MDL Number	-
Synonym	4-Phenetidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Phenetidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} Phenetidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} Ethoxyaniline {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {PubChem} Aminophenetole {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Phenetidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Phenetidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Phenetidine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} p-Phenetidine {} {} {} {} {}
EC Number	205-855-5
Beilstein Registry Number	13,436
Merck Number	7228
PubChem Substance ID	9076
Reaxys-RN	606666
Chemical Name Translation	对乙氧基苯胺
Wiswesser Line Notation	ZR DO2
LabNetwork Molecule ID	LN00223398
InChI	InChI=1S/C8H11NO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2,9H2,1H3
Canonical SMILES	NC1=CC=C(OCC)C=C1

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产品应用

测定铜、铁、锰、钒、锌、铬酸盐和氰化物。氧化还原指示剂。有机合成。染料制造。

安全信息

Warnings 危化品目录(2015) IRRITANT

Signal word Danger Warning

GHS Symbol

WGK Germany1

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S46 If swallowed, seek medical advice immediately and show this container or label 食入时，立即求医并出示容器/标签；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；

Risk Statements

R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
R36 Irritating to eyes 刺激眼睛
R33 Danger of cumulative effects 有累积作用的危险
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P301+P312
P301+P312+P330
P301+P317
P302+P317
P302+P350
P302+P352
P302+P352+P333+P313+P362+P364
P304+P312
P304+P340
P304+P340+P311
P305+P351+P338
P305+P351+P338+P337+P313
P308+P313
P311 Call a POISON CENTER or doctor/physician. 呼叫解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医，如果你觉得不舒服
P316
P317
P318
P319
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P322 Specific measures (see …on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P333+P313
P333+P317
P337+P313
P337+P317
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P233
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

RTECSSI6465500

Packing GroupIII

UN Number UN2311 2311

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature

Hazard statements

H302 Harmful if swallowed 吞食有害
H311 Toxic in contact with skin 皮肤接触中毒
H312 Harmful in contact with skin 皮肤接触有害
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H319 Causes serious eye irritation 严重刺激眼睛
H332 Harmful if inhaled 吸入有害
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
H341 Suspected of causing genetic defects 怀疑导致遗传性缺陷

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

Hazard Codes T,Xi,Xn Xn T;Xn 6.1

Hazard Class6.1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 692 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JMCMAR Journal of Medicinal Chemistry.  (American Chemical Soc.,
   Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
   20037)  V.6-    1963-  Volume(issue)/page/year: 17,900,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 540 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   GISAAA Gigiena i Sanitariya.  For English translation, see HYSAAV.  (V/O
   Mezhdunarodnaya Kniga, 113095 Moscow, USSR)  V.1-    1936-
   Volume(issue)/page/year: 43(1),92,1978

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NYKZAU Nippon Yakurigaku Zasshi.  Japanese Journal of Pharmacology. (Nippon
   Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho,
   Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40-    1944- Volume(issue)/page/year:
   52,215,1956

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 2353 mg/kg
TOXIC EFFECTS :
   Cardiac - other changes
   Lungs, Thorax, or Respiration - emphysema
   Kidney, Ureter, Bladder - hematuria
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientifi

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 1 umol/plate
REFERENCE :
   CPBTAL Chemical and Pharmaceutical Bulletin.  (Japan Pub. Trading Co., USA,
   1255 Howard St., San Francisco, CA 94103)  V.6-    1958-
   Volume(issue)/page/year: 33,2877,1985

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 160 umol/L
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 3,51,1988

Restrict 危险品

其他信息

上游原料:乙醇 --> 氢氧化钠 --> 甲醇 --> 硫化钠 --> 4-硝基氯苯 --> 4-氨基苯酚 --> 4-硝基苯乙醚
{
毒性分级:中毒
TCI Shanghai:对乙氧基苯胺 p-Phenetidine,>;98.0%(GC)(156-43-4)
用途一:用作医药、染料、食品防腐剂、饲料添加剂、橡胶防老剂的中间体
下游产品:酸性蓝 90 --> 非那西丁 --> 酸性蓝 83 --> 乙氧基喹啉 --> 防老剂AW --> 抗痨息 --> N-(4-乙氧基苯基)-3-羟基-2-萘甲酰胺
Hazard Note:Irritant
{Chemi
方法一:1.由对硝基苯乙醚（[100-29-8]）还原而得。将硫
类别:有毒物品
MSDS 信息:4-乙氧基苯胺(156-43-4).msds
用途三:测定铜、
对乙氧基苯胺价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 P0090 对乙氧基苯胺 p-Phenetidine 500G 792元 2014/06/02 P0090 对乙氧基苯胺 p-Phenetidine 25G 137元 2010/06/21 130200050 对乙氧基苯胺 p-Phenetidine 98% 5 GR 247元
图谱信息:对乙氧基苯胺(156-43-4)红外图谱(IR2) 对乙氧基苯胺(156-43-4)红外图谱(IR1) 对乙氧基苯胺(156-43-4)核磁图( 13 CNMR) 对乙氧基苯胺(156-43-4)质谱(MS) 对乙氧基苯胺(156-43-4)核磁图( 1 HNMR)
常规方法:贮存于搪玻璃、不锈钢或铝制容器中，避光密闭贮存。
MOL 文件:156-43-4.mol
急性毒性:口服-大鼠 LD50: 540 毫克/公斤; 口服-小鼠 LD50: 530 毫克/公斤
方法一:1.由对硝基苯乙醚（[100-29-8]）还原而得。将硫化钠、硫磺加水升温至138-142℃，溶液静置澄清后加入还原锅内。加热搅拌，于5-6.5h内均匀缓慢加完对硝基苯乙醚，在132-134℃常压反应3h，在138-140℃加压（0.1MPa以下）反应10-12h。加水搅拌后静置1h。分去下层硫代硫酸钠母液，上层油层分净残渣，减压蒸馏，收集168-170℃（5.33kPa）馏分，得含量99%的对乙氧基苯胺。收率95%以上。也可采用加氢还原，以镍作催化剂，在130-140℃，0.6MPa压力下通氢反应，对硝基苯乙醚还原为对乙氧基苯胺。另外，以硝基苯为原料，在硫酸存在下，采用氧化镍为催化剂，二甲亚砜为促进剂，与无水乙醇乙氧基化，并还原一步制得对乙氧基苯胺。2.对氨基苯酚法　经与氯乙烷反应
储运特性:库房通风低温干燥; 与食品原料分开储运
外观性质:
海关编码:29222200
Alfa Aesar:对乙氧基苯胺,98% p-Phenetidine, 98%(156-43-4)
灭火剂:雾状水、二氧化碳、砂土、干粉
Acros Organics:4-乙氧基苯胺/对氨基苯乙醚 p-Phenetidine, 98%(156-43-4)
用途二:该品用于生产橡胶防老剂AW，即6-乙氧基-2,2,4-三甲基-1,2-二氢化喹啉。也用于饲料和食品，可防止脂肪、蛋白质在贮存过程中氧化变质，还用于维生素A和维生素E等药品的保存。作为饲料和食品抗氧化剂时，称乙氧喹（[91-53-27]）。在医药方面，用于生产解热镇痛药非那西丁、安痨息和消毒防腐药利凡诺。在染料方面，该品是色酚AS-VL、茜素红5G和坚牢酸性蓝R的中间体。
防护措施:高毒。小鼠灌胃LD50为540mg/kg；大鼠灌胃LD50为580mg/kg。空气中最高容许浓度0.2mg/m3。防护方法参见“对甲氧基苯胺”。
敏感性:Air Sensitive