CAS 121-60-8 MFCD00007442-4-Acetamidobenzene-1-sulfonyl chloride 对乙酰胺基苯磺酰氯 TAO{mole}

4-Acetamidobenzene-1-sulfonyl chloride 对乙酰胺基苯磺酰氯

CAS 121-60-8 MFCD00007442

化学结构图

SMILES: CC(=O)Nc1ccc(S(=O)(=O)Cl)cc1

化学属性

Mol. Formula	C8H8ClNO3S
Mol. Weight	234
Density	1.422
Melting Point	142-145 °C (dec.)(lit.)
TSCA	Yes
Solubility	略溶于水
Appearance	对乙酰胺基苯磺酰氯(121-60-8)为浅褐色针状（从苯中）或棱柱状（从苯和氯仿中）结晶。熔点149℃（分解）。溶于苯，乙醚，氯仿和二氯乙烷。在空气中易吸潮分解。有轻微乙酸气味。

别名和识别编码

Chemical Name	4-Acetamidobenzene-1-sulfonyl chloride
CAS Number	121-60-8
Synonym	NASC 4-(Acetylamino)benzene-2,3,5,6-sulfonyl Chloride 4’-(chlorosulfonyl)acetanilide ASC 4-乙酰胺基苯磺酰氯, 98+% 氯化-N-乙酰基对氨基苯磺酰 N-Acetylsulfanilyl chloride p-(Chlorosulfonyl)acetanilide P-ACETAMINOBENZENESULFONYL CHLORIDE Dagenan chloride p-Acetamidophenylsulfonyl chloride Dagenan Chloride N-ACETYLSULFANILYL CHLORIDE 4-ACETAMIDOBENZENESULFONYL CHLORIDE 4'-(Chlorosulfonyl)acetanilide N-ACETYLSULPHANILYL CHLORIDE 对乙酰氨基苯磺酰氯 NSC 127860 N-Acetylsulfanilyl Chloride 4-Chlorosulfonylacetanilide 4-乙酰氨基苯磺酰氯 N(sup 4)-Acetylsulfanilyl chloride 4-Acetamidophenylsulfonyl chloride 4-Acetamidobenzenesulfonyl chloride; ASC {Chemicalbook
EC Number	204-485-1
Beilstein Registry Number	14(3)2043
MDL Number	MFCD00007442
Merck Number	103
PubChem Substance ID	87561773
Reaxys-RN	746676
Chemical Name Translation	对乙酰胺基苯磺酰氯
LabNetwork Molecule ID	LN00221914
InChI	InChI=1S/C8H8ClNO3S/c1-6(11)10-7-2-4-8(5-3-7)14(9,12)13/h2-5H,1H3,(H,10,11)

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产品应用

A sulfanilamide derivative of Chitosan

安全信息

Signal word Danger

GHS Symbol

WGK Germany3

Safety Statements

S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R37 Irritating to respiratory system 刺激呼吸道
R34 Causes burns 会导致灼伤
R22 Harmful if swallowed 吞咽有害
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

Precautionary statements

P234 Keep only in original container. 只保留在原来的容器中。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P330+P331+P310
P303+P361+P353
P303+P361+P353+P310+P363
P304+P340+P310
P305+P351+P338
P305+P351+P338+P310
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P390 Absorb spillage to prevent material damage. 吸收溢出物，防止重大损害。
P405 Store locked up. 上锁保管。
P406 Store in corrosive resistant/… container with a resistant inner liner. 存放在耐腐蚀/具有耐性的内衬容器。
P501 Dispose of contents/container to..… 处理内容物/容器.....

RTECSDB8837500

Packing GroupIII

UN Number 3261 UN 3261 8/PG 2

Storage condition Moisture Sensitive

Hazard statements

H290 May be corrosive to metals 可能腐蚀金属。
H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
H335 May cause respiratory irritation 可能导致呼吸道刺激

Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes C 8

Hazard Class8

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >3200 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0533583

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1600 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0533583

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0533583

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 50 mg/kg
TOXIC EFFECTS :
   Behavioral - muscle weakness
   Behavioral - ataxia
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: OTS0533583

其他信息

急性毒性:口服-大鼠LD50:>;2300毫克/公斤;口服-小鼠 LD50: 1600 毫克/公斤
毒性分级:中毒
可燃性危险特性:可燃;加热分解释放极毒氮氧化物, 硫氧化物和氯化物烟雾
类别:有毒物品
用途二:多种磺胺药物的中间体，如磺胺噻唑，磺胺异噁唑，磺胺甲基异噁唑，磺胺苯吡唑，磺胺二甲异嘧啶等。也是染料的中间体。
TCI Shanghai:对乙酰氨基苯磺酰氯 4-Acetamidobenzenesulfonyl Chloride,>;97.0%(T)(121-60-8)
对乙酰胺基苯磺酰氯价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 A0074 4-乙酰氨基苯磺酰氯 4-Acetamidobenzenesulfonyl Chloride 25G 163元 2014/06/02 A0074 4-乙酰氨基苯磺酰氯 4-Acetamidobenzenesulfonyl Chloride 500G 831元 2010/06/21 150725000 对乙酰胺基苯磺酰氯 N-Acetylsulfanilyl chloride 99% 500 GR 527元
下游产品:(1R,2R)-N-BOC-1-氨基-2-苯基环丙羧酸 --> 磺胺 --> 磺胺甲恶唑 --> 荧光增白剂 NR,赫司特鲁克斯 --> 4-(吗啉磺酰)苯胺 --> 对乙酰氨基苯亚磺酸
灭火剂:干粉、泡沫、砂土和水
MOL 文件:121-60-8.mol
方法一:乙酰苯胺氯磺化下面是两个工业操作示例。操作示例1 搅拌下将67.5kg乙酰胺基苯加到290kg氯磺酸中，控制加料温度在15℃以下,加毕渐升温至60℃，保温搅拌2h，然后将反应物逐渐加于冰水中稀释，温度保持10℃以下，过滤，用冰水漂洗至刚果红试纸呈中性。得对乙酰氨基苯磺酰氯。操作示例2 在20℃ 以下将乙酰胺基苯均匀加入氯磺酸中，按重量计,乙酰苯胺：氯磺酸＝1:5.26，在50± 2℃反应3h。放置8h后，约20℃以下，加适量水分解过剩的氯磺酸，温度不超过28℃，稍冷，过滤，洗涤滤饼至pH=3-4，得对乙酰氨基磺酰氯。收率为83%。该品不宜久存，作为医药和染料生产的中间产物，含量为30%。
Acros Organics:4-乙酰氨基苯磺酰氯 N-Acetylsulfanilyl chloride, 99%(121-60-8)
储运特性:库房通风低温干燥
图谱信息:对乙酰胺基苯磺酰氯(121-60-8)红外图谱(IR1) 对乙酰胺基苯磺酰氯(121-60-8)红外图谱(IR2)
MSDS 信息:4-Acetamidobenzenesulfonyl chloride(121-60-8).msds
Alfa Aesar:4-乙酰胺基苯磺酰氯,98+% 4-Acetamidobenzenesulfonyl chloride, 98+%(121-60-8)
Sigma Aldrich:121-60-8(sigmaaldrich)
F:9-21
用途一:用于制备磺胺间二甲氧嘧啶、磺胺甲基异恶唑等磺胺类药
海关编码:29242995
敏感性:Moisture Sensitive
上游原料:氨基苯 --> 氯磺酸 --> 乙酰胺 --> 刚果红试纸 --> 氨基磺