CAS 57-57-8 MFCD00005169-β-Propiolactone β-丙内酯 TAO{mole}

β-Propiolactone β-丙内酯

CAS 57-57-8 MFCD00005169

化学结构图

SMILES: O=C1CCO1

化学属性

Mol. Formula	C3H4O2
Mol. Weight	72.06
Refractive index	1.4110 to 1.4150
Boiling Point	162 °C at 760 mmHg
Density	1.146
Melting Point	-33 °C
Flash Point	70°C
TSCA	Yes
Solubility	溶于水，可混溶于乙醇。

别名和识别编码

Chemical Name	β-Propiolactone
CAS Number	57-57-8
Synonym	Propiolactone {LY} Propiolactone {} {LY} Propiolactone {} {} {LY} Propiolactone {} {} {} {LY} Propiolactone {} {} {} {} {LY} Propiolactone {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Propiolactone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID	2365
EC Number	200-340-1
MDL Number	MFCD00005169
Beilstein Registry Number	17(3/4)41
Reaxys-RN	1360
Merck Number	7820
Chemical Name Translation	β-丙内酯
Wiswesser Line Notation	T4OVTJ
LabNetwork Molecule ID	LN01313535
InChI	InChI=1S/C3H4O2/c4-3-1-2-5-3/h1-2H2
Canonical SMILES	O=C1OCC1

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产品应用

作药物、树脂和纤维改性剂的中间体，也用作杀菌消毒剂和疫苗灭活剂，用于血浆和疫苗的杀菌。衍生物β-巯基丙酸是PVC稳定剂和医药的原料。

安全信息

GHS Symbol

WGK Germany3

Hazard Codes T+

Hazard statements

H227 Combustible liquid 可燃液体
H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H330 Fatal if inhaled 吸入致命
H350 May cause cancer 可能致癌

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSRQ7350000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P203
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P264+P265
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P284 Wear respiratory protection.? 佩戴呼吸保护装置。
P301+P310
P302+P350
P302+P352
P302+P352+P332+P313+P362+P364
P304+P340
P304+P340+P310
P305+P351+P338
P305+P351+P338+P310
P308+P313
P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P316
P318
P320 Specific treatment is urgent (see … on this label). 紧急具体治疗（见本标签上的）。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P330 Rinse mouth. 漱口
P332+P313
P332+P317
P333+P313
P337+P313
P337+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P370+P378
P403+P233
P403+P235
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word

Safety Statements

S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；

Risk Statements

R26 Very toxic by inhalation 吸入极毒
R45 May cause cancer 可能致癌
R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

UN Number UN 3382 6.1/PG 1 3382

Storage condition 2-8°C {LY} 2-8°C <0°C <;0 Moisture Sensitive {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY}

Packing GroupI

Hazard Class6.1

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40 mg/kg
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   10,357,1956

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 50 mg/kg/25W-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Tumorigenic - tumors at site of application
REFERENCE :
   BJCAAI British Journal of Cancer.  (Macmillan Press Ltd., Houndmills,
   Basingstoke, Hants. RG21 2XS, UK)  V.1-    1947-  Volume(issue)/page/year:
   15,85,1961

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 ppm/6H/30D-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Sense Organs and Special Senses (Olfaction) - tumors
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 79,285,1987

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3050 mg/kg/61W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volum

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 405 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,911,1979

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 25 ppm/6H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
   Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
   Industrial Hygienists, Inc., 1986  Volume(issue)/page/year: 5,497,1986

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 uL/plate
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   1,387,1981

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 8300 ug/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 192,239,1987

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 250 ppm
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 6,189,1984

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 340 nmol/plate
REFERENCE :
   PNASA6 Proceedings of the National Academy of Sciences of the United States
   of America.  (National Academy of Sciences, Printing & Pub. Office, 2101
   Constitution Ave., Washington, DC 20418) V.1-    1915-
   Volume(issue)/page/year: 79,5971,1982

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Bacteria - Bacillus subtilis
DOSE/DURATION           : 110 nmol/L
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   41,4368,1981

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 200 ug/L
REFERENCE :

其他信息

下游产品:丙烯酸正丁酯 --> 丙烯酸乙酯 --> 6-溴-3,4-二氢-4-羟基-2H-苯并吡喃 --> 3-巯基丙酸 --> N,N-二甲基,对十八烷基苯磺酰胺丙基铵基丙磺酸盐 --> 6-溴-4-二氢色原酮 --> N,N-二羟乙基,N-对十八烷基苯磺酰胺丙基铵基丙磺酸盐
可燃性危险特性:易燃; 火场释放辛辣刺激烟雾；在水中迅速水解
Alfa Aesar:β-丙内酯,97% beta-Propiolactone, 97%(57-57-8)
方法一:由乙酸裂解制得乙烯酮，再与甲醛按摩尔比3：1配合，以氯为稀释剂，在BF3催化剂作用下气相缩合或液丁缩合而成。
爆炸物危险特性:与空气混合可爆
MSDS 信息:β-丙内酯(57-57-8).msds
用途一:用作药物、树脂和纤维改性剂的中间体，也用作杀菌消毒剂，用于血浆和疫苗的杀菌。衍生物β-巯基丙酸是PVC稳定剂和医药的原料。
灭火剂:二氧化碳, 干粉
职业标准:TWA 1.5 毫克/立方米
类别:有毒物质
急性毒性:吸入-大鼠 LC50: 25 ppm/6小时; 腹腔-小鼠 LD50: 405 毫克/公斤
上游原料:乙醚 --> 乙腈 --> 四氯化碳 --> 环己烷 --> 挥发性漆稀释剂 --> 1,8-二氮杂双环[5.4.0]十一碳-7-烯 --> 氧化二乙酰丙酮合钒 --> 1,3-丙二醇 --> 3-溴丙酸
能与丙酮、乙醚和氯仿混溶，在水中溶解为37%，其水溶解迅速全部水解。
用途二:作药物、树脂和纤维改性剂的中间体，也用作杀菌消毒剂，用于血浆和疫苗的杀菌。衍生物β-巯基丙酸是PVC稳定剂和医药的原料。
毒性分级:高毒
存储注意事项:光敏感;氩气保护
Sigma Aldrich:57-57-8(sigmaaldrich)
TCI Shanghai:β-丙内酯 beta-Propiolactone,>;95.0%(GC)(T)(57-57-8)
储运特性:库房低温, 通风, 干燥; 防潮
beta-丙内酯价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 H0168 β-丙内酯 beta-Propiolactone 25G 3300元 2014/06/02 H0168 β-丙内酯 beta-Propiolactone 5G 920元 2010/06/21 269041000 beta-丙内酯 beta-Propiolactone 98%, pure 100 ML 12585元
外观性质:无色液体。
Acros Organics:beta-丙内酯 beta-Propiolactone, pure, 98%(57-57-8)
MOL 文件:57-57-8.mol