1,2-Epoxycyclohexane 1,2-环氧环己烷
CAS 286-20-4 MFCD00005162
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分类
- {SNA} Epoxide Monomers, Materials Science, Monomers, Polymer Science
- {uni_hamburg} no charge; oxygen heterocycle; carbocycle; alicycle; large ring; fused rings; 3ring; 6ring; 7ring; ether; 1fragment
- {SNA} Epoxide Monomers, Monomers, Polymer Science, 材料科学
- {Chemicalbook} 农药中间体: 杀螨剂中间体
相关文献及参考
- Rearrangement to cyclopentanecarboxaldehyde is catalyzed by LiBr on alumina, either by refluxing in toluene or in the gas phase: Synthesis, 394 (1988). An alternative isomerization to the allylic alcohol is induced by base catalysis. Optimized conditions use a mixture of KO-t-Bu and 2.5 equivalents of LDA: Tetrahedron, 46, 2411 (1990). For discussion of the mechanism, see: J. Org. Chem., 61, 820 (1996), and references therein. For a review of the rearrangement of epoxides to allylic alcohols, see: Org. React., 29, 345 (1983).
- Short: II/25D
- A general method for the conversion of epoxides to cis-dichloro alkanes, with inversion at both centers, by reaction with triphenylphosphine dichloride, has been exemplified: Org. Synth. Coll., 6, 424 (1988).
- A general method for the synthesis of ɑ-chloro carbonyl compounds is illustrated by the reaction of cylohexene oxide with the Swern reagent (DMSO/ oxalyl chloride) to give 2-chlorocyclohexanone in 93% yield: Tetrahedron, 51, 2467 (1995).
- Beilstein:17,21
安全信息
GHS Symbol
- H226 Flammable liquid and vapour 易燃液体和蒸气
- H302 Harmful if swallowed 吞食有害
- H311+H331
- H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
- P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
- P233 Keep container tightly closed. ?保持容器密闭。
- P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
- P241+P242+P243
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312+P330
- P302+P352+P332+P313+P362+P364
- P303+P361+P353
- P305+P351+P338+P337+P313
- P332+P313
- P337+P313
- P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
- P370+P378
- P403+P235
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- R10 Flammable 易燃
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- R34 Causes burns 会导致灼伤
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 79 mg/kg TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors REFERENCE : RARSAM Radiation Research, Supplement. (New York, NY) No.1-7, 1959-67. Discontinued. Volume(issue)/page/year: 3,193,1963
TYPE OF TEST : LCLo - Lowest published lethal concentration ROUTE OF EXPOSURE : Inhalation SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 2000 ppm/4H TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 549 mg/kg TOXIC EFFECTS : Behavioral - tremor REFERENCE : TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 52,422,1980
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : JSICAZ Journal of Scientific and Industrial Research, Section C: Biological Sciences. (New Delhi, India) V.14-21, 1955-62. For publisher information, see IJEBA6. Volume(issue)/page/year: 21,342,1962
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1090 uL/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958- Volume(issue)/page/year: 30,470,1969
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intramuscular SPECIES OBSERVED : Rodent - mouse DOSE/DURATIO
TYPE OF TEST : Mutation in mammalian somatic cells TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 5 mmol/L REFERENCE : CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 51,77,1984
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Klebsiella pneumoniae DOSE/DURATION : 5 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,269,1981
TYPE OF TEST : Sister chromatid exchange TEST SYSTEM : Rodent - hamster Lung DOSE/DURATION : 5 mmol/L REFERENCE : MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,55,1991
TYPE OF TEST : Mutation in microorganisms TEST SYSTEM : Bacteria - Salmonella typhimurium DOSE/DURATION : 10 umol/plate REFERENCE : BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 29,1068,1980
其他信息
- 方法一:环氧环己烷由环己烯氧化制得。 制备实例1 向2
- {Chem
- 方法一:环氧环己烷由环己烯氧化制得。 制备实例1 向250mL的反应器中加入二噁烷58g、环己烯82g(1mol)和三氧化二砷(As 2 O 3 )0.1g,加热至92℃之后,经3h添加23.12g(0.476mol)70%过氧化氢水溶液溶解于90g二噁烷中的溶液,共沸蒸馏除去水。添加完毕,反应产物中含0.035mol过氧化氢和0.432mol的环氧环己烷,过氧化氢的转化率为92.6%,选择性97.9%。 制备实例2 正丙醇35g、环己烯41.4g(0.505mol)、二羟基三甲基锑0.503g(0.0025mol)、六羰基钨0.514g(0.0015mol)和过氧化氢121.5mol(70%,5.92g)的混合物保持60℃,反应3h后得到环氧环己烷10g(0.102mol),过氧化氢转化率为90%,环氧环己烷选择性为92.5%。制备实例3 向带有搅拌器、回流冷凝器的300mL反应器中加入47g二甘醇二甲醚、82g(1mol)环己烯和0.2g(0.03mol)无水硼酸(B 2 O 3 ),反应混合物加热回流后,经30min添加20g(0.0485mol)70%过氧化氢水溶液溶解于20g二甘醇二甲醚中的溶液。反应介质中的水与环己烷共沸连续除去。反应1h后,反应物中含0.0013mol未反应的过氧化氢,在馏出的水中含过氧化氢0.0052mol,反应物中含0.041mol环氧环己烷,转化率为86.7%,选择性为97.6%。 制备实例4 向带有搅拌器、回流冷凝器的500mL反应器中加入戊醇41g、氧化钼0.05g、磷酸二钠0.3g和环己烯41g(0.5mol),加热至环己烯的沸点81℃,经12min添加30%过氧化氢的水溶液5.7g(0.05mol),反应2h,通过与环己烯的共沸除去水,反应温度保持在80~90℃。反应产物中残留0.012
- 毒性分级:中毒
- 储运特性:库房通风低温干燥; 与氧化剂分开存放; 不宜久储, 以防聚合
- 氧化环己烯价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30219180 环氧环己烷 500ml 1057元 2011/04/16 O0071 1,2-环氧环己烷 1,2-Epoxycyclohexane 500ML 1530元 2011/04/16 O0071 1,2-环氧环己烷 1,2-Epoxycyclohexane 25ML 230元
- 上游原料:过氧化氢 -->
- TCI Shanghai:1,2-环氧环己烷 1,2-Epoxycyclohexane,>;98.0%(GC)(286-20-4)
- 海关编码:29109000
- 上游原料:过氧化氢 --> 1,4-二氧六环 --> 环己烯 --> 二乙二醇二甲醚 --> 三氧化二硼 --> 六羰基钨 -->
- 上游原料:过氧化氢 --> 1,4-二氧六环 --> 环己烯 --> 二乙二醇二甲醚 --> 三氧化二硼 --> 六羰基钨 --
- {Chemi
- 急性毒性:口服- 大鼠 LD50: 1090 毫克/ 公斤; 吸入- 大鼠 LCL0: 2000 PPM/ 4小时
- 灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
- 下游产品:炔螨
- 外观性质:无色透明液体,具有强烈气味。
- {Ch
- {
- Acros Organics:氧化环己烯 Cyclohexene oxide, 98%(286-20-4)
- 用途二:环氧环己烷是合成杀螨剂炔螨特的原料,此外,由本品合成反-1,2-环己二醇,用于表面活性剂、橡胶助剂、高分子
- 用途二:环氧环己烷是合成杀螨
- MOL 文件:286-20-4.mol
- 类别:易燃液体
- Alfa Aesar:环己烯氧化物,98+% Cyclohexe
- 用途二
- 不溶于水,溶于醇、醚、丙酮以及大多数有机溶剂。
- Alfa Aesar:环己烯氧化物,98+% Cy