CAS 108-90-7 MFCD00000530-Chlorobenzene 超干氯苯 TAO{mole}

Chlorobenzene 超干氯苯

CAS 108-90-7 MFCD00000530

化学结构图

SMILES: Clc1ccccc1

化学属性

Mol. Formula	C6H5Cl
Mol. Weight	113
Refractive index	1.5220 to 1.5260
Boiling Point	-
Density	1.106
Melting Point	-45
Flash Point	23.89°C
TSCA	Yes
Autoignition Point	1178 °F
Vapor Density	3.86 (vs air)
Vapor Pressure	11.8 mmHg ( 25 °C)
Solubility	不溶于水，溶于乙醇、乙醚、氯仿、二硫化碳、苯等多数有机溶剂。
Danger-Level	甲类

别名和识别编码

Chemical Name	Chlorobenzene
CAS Number	108-90-7
Synonym	Chlorobenzene {LY} Chlorobenzene {} {LY} Chlorobenzene {} {} {LY} Chlorobenzene {} {} {} {LY} Chlorobenzene {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Chlorobenzene {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
Beilstein Registry Number	605632
PubChem Substance ID	87558242
EC Number	203-628-5
MDL Number	-
Reaxys-RN	605632
Merck Number	2121
Chemical Name Translation	超干氯苯
Wiswesser Line Notation	GR
LabNetwork Molecule ID	LN00163722
Canonical SMILES	ClC1=CC=CC=C1

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品牌质保精细包装现货库存一流品牌服务

产品应用

溶剂，制造酚、苯胺、滴滴涕、染料等，传热介质。

安全信息

GHS Symbol

WGK Germany2

Hazard Codes 3 Xn;N

Hazard statements

H226 Flammable liquid and vapour 易燃液体和蒸气
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H332 Harmful if inhaled 吸入有害
H315 Causes skin irritation 会刺激皮肤
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
H302+H332

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSCZ0175000

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P304+P340
P305+P351+P338
P308+P313
P332+P313
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Warning

UN Number 1134

Risk Statements

R10 Flammable 易燃
R20 Harmful by inhalation 吸入有害
R51/53

Safety Statements

S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Packing GroupIII

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

Hazard Class3

Warnings 危化品目录(2015)

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 61800 mg/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
   Blood - tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-261,1985

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1110 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - tremor
   Behavioral - ataxia
REFERENCE :
   SRTCAC Science Reports of the Research Institutes, Tohoku University, Series
   C: Medicine. (Tohoku University, Research Institute for Tuberculosis and
   Cancer, 4-1 Seiryo-machi, Sendai, Japan)  V.1-   1949-
   Volume(iss

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : >2200 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: AD-A180-198

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2300 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single
   Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects,
   GKNT, 1982  Volume(issue)/page/year: -,34,1982

TYPE OF TEST            : LD - Lethal dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : >11 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   85INA8 "Documentation of the Threshold Limit Values and Biological Exposure
   Indices," 5th ed., Cincinnati, OH, American Conference of Governmental
   Industr

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 300 mg/L
REFERENCE :
   SCIEAS Science.  (American Assoc. for the Advancement of Science, 1333 H
   St., NW, Washington, DC 20005)  V.1-    1895-  Volume(issue)/page/year:
   236,933,1987

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 225 mg/kg/24H
REFERENCE :
   MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road,
   Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-  Volume(issue)/page/year: 2,111,1987

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 100 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   12,85,1988

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 1000 ppm
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: PB84-138973

TYPE OF TEST            : Cytogenetic analysis
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   25,302,1995

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 70 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagene

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 75 ppm/6H
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   76,365,1984

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 10 ppm/6H
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   76,365,1984

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 210 ppm/6H
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - hepatobiliary system
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   76,365,1984

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 590 ppm/6H
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants

Restrict 危险品

其他信息

用途五:溶剂，制造酚、苯胺、滴滴涕、染料、军用毒气气等，传热
图谱信息:氯苯(108-90-7)核磁图( 13 CNMR) 氯苯(108-90-7)核磁图( 1 HNMR) 氯苯(108-90-7)Raman光谱氯苯(108-90-7)红外图谱(IR1) 氯苯(108-90-7)红外图谱(IR2) 氯苯(108-90-7)质谱(MS)
{
毒性分级:中毒
急性毒
外观性质:无色透明液体，具有不愉快的苦杏仁味。
常规方法:用槽车或铁桶包装。
防护措施:本品具有中等毒性，对皮肤粘膜和上呼吸道有刺激作用。抑制中枢神经系统，具有麻醉作用。对肝脏，肾脏及造血系统有不良影响。慢性中毒引起头痛、头晕、精神不振、消化不良等症状。大鼠经口LD50为2910mg/kg。工作场所最高容许浓度为350mg/m3。防治方法：杜绝跑、冒、滴、漏。加强现场通风排气。操作人员穿戴防护用具，避免与人体直接
MS
储运特性:库房通风低温干燥; 与氧化剂分开存放
上游原料:盐酸 --> 苯 --> 氯 --> 酸性氧化铝 --> 邻二氯苯 --> 铁屑 --> 流量计 --> 对二氯苯 --> 无水氯化铁
用途一:用作染料、医药、农药、有机合成的中间体及溶剂
用途二:用作分析试剂和有机溶剂，也用于有机合成
氯苯价格(试剂级):更新日期产品编号产品名称包装价格
Sigma Aldrich:108-90-7(sigmaaldrich)
Acros Organics:氯苯 Chlorobenzene, pure, 99+%(108-90-7)
下游产品:4-氯苯磺酰氯 --> 2-叔丁基-4-氰基吡啶 --> alpha-氯乙酰苯 --> 阿特拉津 --> 苯基三氯硅烷 --> 5-溴噻吩-2-甲醛 --> 5-氯-3-甲基苯并噻吩 --> 6-溴-1,2,3,4-四氢-2-喹啉酮 --> 3-氯苯并(B)噻吩-2-羰基氯 --> {2-[6-(2-氯苯氧基)-5-氟嘧啶-4-基氧]苯基}(5,6-二氢-1,4,2-二噁嗪-3-基)甲酮O-甲基肟 --> 5-氯苯并噻吩 --> 3,4'-二氯二苯醚 --> 3-氯苯并噻吩-2-羧酸甲酯 --> 冰染偶合组分 18 --> 3-羟基-N-(3-硝基苯基)-2-萘甲酰胺 --> 2,2'-(1,3,4,-恶二唑-2,5-二基)双[1-氨基-9,10-蒽二酮 --> 2-溴-4-硝基咪唑 --> 3-氯苯并呋喃-2-羧肼 --> 2,5-噻吩二羧酸 --> α-氯代苯乙酸乙酯 --> 巴氯芬 --> 2,2-双(对氯苯基)-1,1,1-三氯乙烷 --> 色酚 AS-PH --> N-萘-1-基-3-羟基萘-2-甲酰
用途三:氯苯用于生产农药品种三氯杀螨砜、滴滴涕等，还用于合成染料、医药以及其他有机化工产品，也用作乙基纤维素和许多树脂的溶剂以及生产多种中间体，例如对二氯苯、对氯苯磺酸、2，4-二硝基氯苯、邻硝基氯苯、对硝基氯苯、硝基酚等。
可燃性危险特性:遇明火、高温、氧化剂易燃; 燃烧产生有毒氯化物烟雾
方法一:氯苯是由苯直接氯化制得，这是英国于1909年首先进行工业化生产的方法，一直沿用至今。氯化工艺有气相法和液相法两种，气相法反应温度400～500℃，成本比液相法高，故已被淘汰；液相法又有间歇法和连续法两种。 (1)间歇法把干燥的苯装入氯化反应器中，再加入相当于苯量1％的铁屑作催化剂，氯气的加入速度以能维持反应温度在40～60℃为宜，温度过高有利于多氯苯的生产。氯气鼓泡通入苯中至料液的相对密度达到1.280(15℃)。反应放出的氯化氢用苯或氯苯洗除有机雾滴，再用水吸收得到盐酸。氯化物料用10％的氢氧化钠中和，并经干燥、蒸馏，得下列馏分(以100％氯化料计)：苯和水(3％)，苯和氯苯(10％)，此二馏分返回系统；氯苯(75％)作为产品；氯苯和二氯苯(10％)，高沸物(2％)，此二馏分用于分离邻、对二氯苯。氯化产品的组成决定于氯化温度、氯化速率、氯化深度和采用的催化剂。一般氯化