CAS 99-56-9 MFCD00007724-4-Nitrobenzene-1,2-diamine 4-硝基邻苯二胺 TAO{mole}

4-Nitrobenzene-1,2-diamine 4-硝基邻苯二胺

CAS 99-56-9 MFCD00007724

化学结构图

SMILES: Nc1ccc([N+](=O)[O-])cc1N

化学属性

Mol. Formula	C6H7N3O2
Mol. Weight	153.14
Melting Point	199-201°C
TSCA	Yes
Density	1.446
Solubility	1.2 G/L (20 ºC)
Appearance	暗红色针状结晶。熔点201℃，溶于乙醇、丙酮及盐酸溶液，难溶于水。
Boiling Point	276.04 °C at 760 mmHg

别名和识别编码

Chemical Name	4-Nitrobenzene-1,2-diamine
CAS Number	99-56-9
Alfabeta Name	NITROPHENYLENEDIAMINE M4---
MDL Number	MFCD00007724
Synonym	4-Nitrobenzene-1,2-diamine {LY} 4-Nitrobenzene-1,2-diamine {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Nitrobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {}
Beilstein Registry Number	608106
PubChem Substance ID	87566843
EC Number	202-766-3
Reaxys-RN	608106
Merck Number	6622
Chemical Name Translation	4-硝基邻苯二胺
Wiswesser Line Notation	ZR BZ DNW
LabNetwork Molecule ID	LN00173496
InChI	InChI=1S/C6H7N3O2/c7-5-2-1-4(9(10)11)3-6(5)8/h1-3H,7-8H2
Canonical SMILES	NC1=CC=C([N+]([O-])=O)C=C1N

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

主要用于合成药物及合成颜料、染料等。

安全信息

Warnings IRRITANT

Precautionary statements

P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P312+P330
P302+P352+P333+P313+P362+P364
P305+P351+P338
P305+P351+P338+P337+P313
P501 Dispose of contents/container to..… 处理内容物/容器.....

WGK Germany3

GHS Symbol

Signal word Warning

Hazard statements

H317 May cause an allergic skin reaction 可能导致皮肤过敏
H302 Harmful if swallowed 吞食有害

Hazard Codes Xn

RTECSST2975000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Safety Statements

S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；

Risk Statements

R22 Harmful if swallowed 吞咽有害
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R68 Possible risk of irreversible effects 可能有不可挽回的作用的危险

UN Number 2811

Packing GroupII

Hazard Class6.1

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 681 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
   the National Cancer Institute by Litton Bionetics, Inc.  (Bethesda, MD)
   Volume(issue)/page/year: NCI-E-C-72-3252,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 681 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to
   the National Cancer Institute by Litton Bionetics, Inc.  (Bethesda, MD)
   Volume(issue)/page/year: NCI-E-C-72-3252,1973

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : >1600 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JTEHD6 Journal of Toxicology and Environmental Health.  (Hemisphere Pub.,
   1025 Vermont Ave., NW, Washington, DC 20005)  V.1-    1975/76-
   Volume(issue)/page/year: 2,657,1977

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 500 ug/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   26,147,1995

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 1200 umol/L/3D
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 48,181,1977

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 104 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 203,155,1988

TYPE OF TEST            : DNA repair
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 10 mg/L
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   South

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Parenteral
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 5 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 56,31,1977

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - hamster Lung
DOSE/DURATION           : 40 mg/L
REFERENCE :
   GMCRDC Gann Monograph on Cancer Research.  (Plenum Pub. Corp., 233 Spring
   St., New York, NY 10013) No. 11-    1971-  Volume(issue)/page/year:
   27,95,1981

TYPE OF TEST

{h

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 7680 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured
   before birth)
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 24,253,1981

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 3 gm/kg
SEX/DURATION            : male 30 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   SheCW# Personal Communication from C.W. Sheu, Genetic Toxicology Branch,
   FDA, Mar. 25, 1977  Volume(issue)/page/year: 25MAR1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 2560 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - craniofacial
   (including nose and tongue)
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 19,37A,1979

Storage condition 2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

其他信息

急性毒性:口服-大鼠LD50: 681 毫克/公斤; 口服-小鼠LD50: 681 毫克/公斤
Acros Organics:4-硝基-1,2-苯二胺 4-Nitro-o-phenylenediamine, 98%(99-56-9)
储运特性:库房通风低温干燥
用途二:用于合成α-酮酸；检测硒的试剂。
上游原料:活性炭(脱色) --> 2,4-二硝基苯胺
Alfa Aesar:4-硝基邻苯二胺,97% 4-Nitro-o-phenylenediamine, 97%(99-56-9)
毒性分级:中毒
TCI Shanghai:4-硝基-1,2-苯二胺 4-Nitro-1,2-phenylenediamine,>;97.0%(GC)(T)(99-56-9)
溶解度: 1.2 g/l水 (20°C) ，20 g/l 丙酮 (20°C)。溶于盐酸水溶液。
海关编码:29215119
MSDS 信息:3,4-Diaminonitrobenzene(99-56-9).msds
用途一:主要用于合成药物及合成颜料、染料等
Sigma Aldrich:99-56-9(sigmaaldrich)
灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
图谱信息:4-硝基邻苯二胺(99-56-9)质谱(MS) 4-硝基邻苯二胺(99-56-9)红外图谱(IR1) 4-硝基邻苯二胺(99-56-9)核磁图( 13 CNMR) 4-硝基邻苯二胺(99-56-9)核磁图( 1 HNMR) 4-硝基邻苯二胺(99-56-9)红外图谱(IR2)
方法一:将23.8g2,4-二硝基苯胺、240ml95%乙醇及120ml浓氨水的混合物加热到45℃，搅拌下通入硫化氢气体，维持在45-55℃反应。反应毕，冷却，析出4-硝基邻苯二胺。将过滤得到的粗品溶于盐酸，加活性炭脱色，趁热过滤，滤液用浓氨水中和，过滤，水洗，干燥，即得成品，收率52-58%。
4-硝基邻苯二胺价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 D0103 4-硝基-1,2-苯二胺 4-Nitro-1,2-phenylenediamine 500G 1140元 2014/06/02 D0103 4-硝基-1,2-苯二胺 4-Nitro-1,2-phenylenediamine 25G 196元 2010/06/21 148845000 4-硝基邻苯二胺 4-Nitro-o-phenylenediamine 98% 500 GR 2579元
MOL 文件:99-56-9.mol
下游产品:5-氨基-2-巯基苯并咪唑 --> 5-溴-6-异硫氰酸喹喔啉 --> 6-氨基-5-溴喹喔啉 --> 2-巯基-5-硝基苯并咪唑 --> 6-氨基喹喔啉
可燃性危险特性:可燃;燃烧产生有毒氮氧化物烟雾
类别:有毒物品