CAS 64-75-5 MFCD00078142-Tetracycline Hydrochloride 四环素盐酸盐 TAO{mole}

Tetracycline Hydrochloride 四环素盐酸盐

CAS 64-75-5 MFCD00078142

化学结构图

SMILES: CN(C)C1C(=O)C(C(N)=O)=C(O)C2(O)C(=O)C3=C(O)c4c(O)cccc4C(C)(O)C3CC12.Cl

化学属性

Mol. Formula	C22H24N2O8.HCl
Mol. Weight	481
Melting Point	220-223
TSCA	Yes
Solubility	50 G/L
Density	1.177
Appearance	powder
Refractive index	-253 ° (C=0.5, 0.1mol/L HCl)

别名和识别编码

Chemical Name	Tetracycline Hydrochloride
CAS Number	64-75-5
Synonym	Qidtet {Chemicalbook} TETRACYCLINE HCL {Chem Chlorowodorku tetracykliny [4S-(4?,4a?,5a?,6?,12a?]- [4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hydrochloride Amycin, hydrochloride Piracaps Diacycine S cancycline-25 潮霉素 A 均霉素 Bristacycline 托妥霉素 diacycine Tetracompren Tetra-wedel Tetracycline hydrochloride ALA TET 10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride,[4s-(4alpha,4a 12,12a-pentahydroxy-6-methyl-1,11-dioxo-1monohydrochlori cefracyclinetablets Medamycin Teline 盐酸四环素 Tetralution 盐酸四环 dumocyclin DESCHLOROBIOMYCIN NCI-C55561 amycin,hydrochloride 潮霉素 Vetquamycin-324 四环素盐酸盐 ACHROM alatet [4s-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenec Tetraciclina cloridrato Tetrosol Sumycin Achromycin hydrochloride 5aalpha,6beta,12aalpha)]-alph Chlorhydrate de tetracycline Telotrex TETRACYCLINE HYDROCHLORIDE Tetrabakat Tet-Cy Quatrex Triphacyclin 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,m2-Naphthacenecarboxamide 盐酸三氯噻嗪 artomycin
Beilstein Registry Number	14(4)2625
PubChem Substance ID	87560362
MDL Number	MFCD00078142
EC Number	200-593-8
Reaxys-RN	3844873
Merck Number	9196
Chemical Name Translation	四环素盐酸盐
Wiswesser Line Notation	L E6 C666 BV FV CU GUTTT&J DQ EQ GVZ HQ IN1&1 MQ M1RQ &GH
LabNetwork Molecule ID	LN00242611
InChI	InChI=1S/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25-26,29,31-32H,7H2,1-3H3,(H2,23,30);1H/t9-,10-,15-,21+,22-;/m0./s1

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品牌质保精细包装现货库存一流品牌服务

产品应用

作用模式: 靠阻止胺酰基-tRNA至核糖体30S亚单位上阻止蛋白的合成。
抗菌谱:革兰氏阴性和阳性细菌。
阻断模式: 细胞壁渗透性缺失。

安全信息

GHS Symbol

Precautionary statements

P501 Dispose of contents/container to..… 处理内容物/容器.....
P308+P313
P201 Obtain special instructions before use. 使用前获取专门指示。
P405 Store locked up. 上锁保管。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H319 Causes serious eye irritation 严重刺激眼睛
H335 May cause respiratory irritation 可能导致呼吸道刺激
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
H362 May cause harm to breast-fed children 可能对母乳喂养的婴儿造成伤害

WGK Germany2

RTECSQI9100000

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Signal word

Storage condition -20℃保存。 <;0 <0°C Air & Light Sensitive 2-8°C

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R36 Irritating to eyes 刺激眼睛
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R64 May cause harm to breast-fed babies 可能导致伤害脯乳期婴儿

Hazard Codes Xn Xi

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 700 mg/kg
TOXIC EFFECTS :
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   9,445,1966

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 157 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia,
   Italy)  V.8-43 1953-88 For publisher information, see FRMCE8
   Volume(issue)/page/year: 10,197,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 105 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks
   In New Drugs, Proceedings of the Symposium on Toxicological Testing for
   Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague,
   Czechoslovakia, Univerzita Karlova, 1979  Volume(issue)/page/year: -,55,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2759 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other tha

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Human - man
DOSE/DURATION           : 200 mg/kg/7D-I
TOXIC EFFECTS :
   Sense Org

TYPE OF TEST            : Gene conversion and mitotic recombination
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 3 gm/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 12,357,1971

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 120 mg/L
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-344,1989

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Microorganism - not otherwise specified
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 315,33,1994

TYPE OF TEST            : Cytogenetic analysis
TEST SYSTEM             : Rodent - mouse Mammary gland
DOSE/DURATION           : 31600 ug/L/24H
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 40,261,1976

TYPE OF TEST            : DNA inhibition
TEST SYSTEM             : Rodent -

TYPE OF TEST            : DNA adduct
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 89,95,1981

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 3 mg/L
REFERENCE :
   SHIGAZ Shigaku.  Ondotology.  (Nippon Shika Daigaku Shigakkai, 1-9-20
   Fujimi, Chiyodaku, Tokyo

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 600 mg/kg
SEX/DURATION            : female 8-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteis

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 6 gm/kg
SEX/DURATION            : female 9-14 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
REFERENCE :
   KSRNAM Kiso to Rinsho.  Clinical Report.  (Yubunsha Co., Ltd., 1-5, Kanda
   Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan)  V.1-    1960-
   Volume(issue)/page/year: 4,516,1970

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 900 mg/kg
SEX/DURATION            : female 8-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
   Reproductive

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intrauterine
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 100 mg/kg
SEX/DURATION            : female 1 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   CCPTAY Contraception.  (Geron-X, Inc., POB 1108, Los Altos, CA 94022)  V.1-
   1970-  Volume(issue)/page/year: 29,553,1984

其他信息

盐酸四环素价格(试剂级):更新日期产品编号产品名称包装价格 2010/06/21 233105000 盐酸四环素 Tetracycline hydrochloride , 'can be used as secondary standard' 500 MG 701元 2010/06/21 233100025 盐酸四环素 Tetracycline hydrochloride , 'can be used as secondary standard' 2.5 GR 2333元 2010/05/25 B21408 四环素盐酸盐, 98% Tetracycline hydrochloride, 98% 25g 449元
MOL 文件:64-75-5.mol
MSDS 信息:[4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hydrochloride(64-75-5).msds
注意事项:注意：防潮湿，储存在避光通风处，结块不影响药效避免和碱性农药、污水混合，否则易失效本药现用现配，药液不能久存。
Alfa Aesar:四环素盐酸盐,98% Tetracycline hydrochloride, 98%(64-75-5)
图谱信息:盐酸四环素(64-75-5)红外图谱(IR1) 盐酸四环素(64-75-5)红外图谱(IR2)
Sigma Aldrich:64-75-5(sigmaaldrich)
广谱抗生素:盐酸四环素是一种广谱抗生素，高浓度时具杀菌作用，除了常见的革兰阳性菌、革兰阴性菌以及厌氧菌外，多数立克次体属、支原体属、衣原体属、非典型分枝杆菌属、螺旋体、放线菌属、炭疽杆菌、单核细胞增多性李斯特菌、梭状芽孢杆菌、奴卡菌属对本品敏感。本品对革兰阳性菌作用优于革兰阴性菌，但肠球菌属和耐青霉素的淋球菌对其耐药。本品对弧菌、布鲁菌属、弯曲杆菌、耶尔森菌等革兰阴性菌抗菌作用良好，对铜绿假单胞菌无抗菌活性。抗菌机理在于药物能特异性地与细菌核糖体30S亚基的A位置结合，阻止氨基酰－tRNA在该位上的联结，从而抑制肽连的增长和影响细菌蛋白质的合成而产生抑菌作用，又由于它能够改变细菌胞浆膜的通透性，使之易在菌体内积聚，起到快速抑菌的效果。盐酸四环素是四环素碱的盐酸盐,在生产过程中，经进一步合成、精制而成，纯度高，毒副作用小，贮存期长。口服吸收百分比远远高于四环素碱，进人人体后，血药浓度、尿药浓度、生物利用度均高于四环素碱，而且安全可靠、疗效确切，目前在欧美一些国家仍在广泛使用。盐酸四环素首选用于治疗衣原体感染、立克次体病、支原体肺炎、回归热等非细菌性感染，也用于布鲁菌病、霍乱、兔热病、鼠咬热、炭疽、破伤风、鼠疫、放线菌病、气性坏疽和敏感细菌引起的呼吸系统、胆管、尿路感染及皮肤软组织感染等的治疗。
比旋光度:-252 ° (c=0.5, H2O)
用途二:作用模式: 靠阻止胺酰基-tRNA至核糖体30S亚单位上阻止蛋白的合成。抗菌谱:革兰氏阴性和阳性细菌。阻断模式: 细胞壁渗透性缺失。
用途一:属广谱抗生素
F:8-10-23
溶解度:20 g/L水，5 g/L乙醇，不溶于醚、烃类和丙酮。
TCI Shanghai:盐酸四环素 Tetracycline Hydrochloride,>;98.0%(T)(64-75-5)
Acros Organics:四环素盐酸盐 Tetracycline hydrochloride, 'can be used as secondary standard'(64-75-5)