CAS 5989-27-5 MFCD00062991-Limonene, (+)- (R)-(+)-柠檬烯 TAO{mole}

Limonene, (+)- (R)-(+)-柠檬烯

CAS 5989-27-5 MFCD00062991

化学结构图

SMILES: C=C(C)[C@H]1CC=C(C)CC1

化学属性

Mol. Formula	C10H16
Mol. Weight	136.23
Refractive index	1.4700 to 1.4730
Boiling Point	-
Density	0.842
Flash Point	48.33°C
TSCA	Yes
Melting Point	-74
Vapor Density	4.7 (vs air)
Vapor Pressure	<;3 mmHg ( 14.4 °C)
Stability	不溶于水。
Solubility	Soluble in ethanol, carbon tetrachloride, and glycerin (slightly). Insoluble in water (0.02 mg/ml at 25 °C), and propylene glycol.

别名和识别编码

Chemical Name	(R)-(+)-Limonene
Synonym	(+)-(R)-4-isopropenyl-1-methylcyclohexene (+)-limonene (-)-limonene (4R)-1-methyl-4-(1-methylethenyl)cyclohexene (4S)-1-methyl-4-isopropenylcyclohex-1-ene (D)-limonene (R)-(+)-Limonene (R)-(+)-limonene (R)-4-isopropenyl-1-methylcyclohexene 1-methyl-4-(1-methylethenyl)cyclohexene 4 Mentha 1,8 diene 4-mentha-1,8-diene AISA 5203-L (+)limonene cyclohexene, 1-methyl-4-(1-methylethenyl)-, (4R)- d Limonene d-limonene dipentene limonene limonene, (+)- limonene, (+-)- limonene, (+-)-isomer limonene, (R)-isomer limonene, (S)-isomer {} {} {} {} {} {} {LY} (R)-(+)-Limonene {} {} {} {} {LY} (R)-(+)-Limonene {} {} {} {} {} {LY} (R)-(+)-Limonene {} {} {} {} {} {} {LY} (R)-(+)-Limonene {} {} {} {} {} {} {} {LY} (R)-(+)-Limonene {} {} {} {} {} {} {} {}
CAS Number	5989-27-5
PubChem Substance ID	440917
EC Number	227-813-5
Beilstein Registry Number	2204754
MDL Number	-
Merck Number	5493
Reaxys-RN	2204754
Alfabeta Name	ISOPROPENYLMETHYLCYCLOHEXENE R441()----
Chemical Name Translation	(R)-(+)-柠檬烯
Wiswesser Line Notation	L6UTJ A1 DY1&U1 -R
LabNetwork Molecule ID	LN00183846
InChI	InChI=1S/C10H16/c1-8(2)10-6-4-9(3)5-7-10/h4,10H,1,5-7H2,2-3H3/t10-/m0/s1
Canonical SMILES	CC1=CC[C@H](C(C)=C)CC1

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分类

{SNA} Alkenes, Asymmetric Synthesis, Chemical Synthesis, Chiral Building Blocks, Organic Building Blocks
{SNA} Alkenes, Armoracia rusticana (Horseradish), Artemisia vulgaris, Aspalathus linearis (Rooibos tea), Asymmetric Synthesis, Bioactive Small Molecules, Boswellia carterii, Carthamus tinctorius (Safflower oil), Cell Biology, Chamaemelum nobile (Chamomile tea), Chemical Synthesis, Chemopreventive Agents, Chiral Building Blocks, Citrus aurantium (Seville orange), Curcuma longa (Turmeric), Elettaria Cardamomum (Cardamom), Enzyme Inhibitors, Ephedra sinica, Humulus lupulus (Hops),
{SNA} 76/768/EEC Annex VIII
{SNA} 76/768/EEC Annex VIII,

产品应用

Which activates UGT and hepatic GST.

安全信息

GHS Symbol

WGK Germany3

Hazard Codes 3 Xi,N Xi;N

Hazard statements

H226 Flammable liquid and vapour 易燃液体和蒸气
H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
H412 Harmfutoaquaticlifewithlonglastingeffects 对水生生物有害并具有长期影响。

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSGW6360000

Precautionary statements

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P233 Keep container tightly closed. ?保持容器密闭。
P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
P241+P242+P243
P242 Use only non-sparking tools. 只能使用无火花工具。
P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P301+P310
P301+P316
P302+P352
P302+P352+P333+P313+P362+P364
P303+P361+P353
P305+P351+P338
P305+P351+P338+P337+P313
P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。
P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
P331 Do NOT induce vomiting.. 不要催吐。
P332+P313
P332+P317
P333+P313
P333+P317
P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
P362+P364
P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
P370+P378
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P403+P235
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Signal word Danger Warning

UN Number 2319

Risk Statements

R10 Flammable 易燃
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R38 Irritating to skin 刺激皮肤
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R50/53
R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官

Safety Statements

S24 Avoid contact with skin 避免皮肤接触；
S37 Wear suitable gloves 戴适当手套；
S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；

Packing GroupIII

Warnings 危化品目录(2015) IRRITANT

Hazard Class3

Storage condition 2-8°C {LY} 2-8°C 4°C 4°C, Light sensitive, Light sensitive {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 67 gm/kg/39W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Gastrointestinal - tumors
REFERENCE :
   JNCIAM Journal of the National Cancer Institute.  (Washington, DC)  V.1-60,
   1940-78.  For publisher information, see JJIND8.  Volume(issue)/page/year:
   35,771,1965

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 38625 mg/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Kidney, Ureter, Bladder - Kidney tumors
   Reproductive - Tumorigenic effects - testicular tumors
REFERENCE :
   NTPTR* National Toxicology Program Technical Report Series.  (Research
   Triangle Park, NC 27709) No.206-  Volume(issue)/page/year: NTP-TR-347,1990

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 30200 mg/kg
TOXIC EFFECTS :
   Behavioral - excitement
   Lungs, Thorax, or Respiration - respiratory depression
   Skin and Appendages - hair
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 9,387,1975

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3170 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
REFERENCE :
   SIZSAR Sapporo Igaku Zasshi.  Sapporo Medical Journal.  (Sapporo Igaku
   Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan)  V.3-

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   OYYAA2 Oyo Yakuri.  P

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 600 mg/kg
TOXIC EFFECTS :
   Behavioral - altered sleep time (including change in righting reflex)
   Behavioral - somnolence (general depressed activity)
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 8,1439,1974

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TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE                    : 3250 mg/kg
SEX/DURATION            : female 6-18 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - physical
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 13,885,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20083 mg/kg
SEX/DURATION            : female 9-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 14178 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 13,863,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 3546 mg/kg
SEX/DURATION            : female 7-12 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Effects on Newborn - physical
REFERENCE :
   OYYAA2 Oyo Yakuri.  Pharmacometrics.  (Oyo Yakuri Kenkyukai, CPO Box 180,
   Sendai 980-91, Japan) V.1-    1967-  Volume(issue)/page/year: 13,863,1977

Restrict 危险品

其他信息

D-Limonene is a monoterpene found to prevent mammary cancer by activating hepatic glutathione-S-transferase (GST) and uridine diphosphoglucuronosyl transferase (UGT). D-Limonene is an isoprenylation inhibitor of small G-proteins.
不溶于水。