Ammonium Formate 甲酸铵

CAS 540-69-2 MFCD00013103

化学结构图

540-69-2
SMILES: N.O=CO

化学属性

Mol. FormulaCH5NO2
Mol. Weight63.06
Melting Point119-121 °C
Density1.26
TSCAYes
Solubility可溶
Stability易吸潮
Appearance 无色结晶,熔点116℃,相对密度1.27。易溶于水,溶于醇及氨水。易潮解。
Boiling Point103.28 °C at 760 mmHg

别名和识别编码

Chemical NameAmmonium Formate
CAS Number540-69-2
PubChem Substance ID2723923
MDL NumberMFCD00013103
Synonym Formic acid (ammonium) {LY} Formic acid (ammonium) {} {LY} Formic acid (ammonium) {} {} {LY} Formic acid (ammonium) {} {} {} {LY} Formic acid (ammonium) {} {} {} {} {LY} Formic acid (ammonium) {} {} {} {} {} {LY} Formic acid (ammonium) {} {} {} {} {} {} {LY} Formic acid (ammonium) {} {} {} {} {} {} {} {LY} Formic acid (ammonium) {} {} {} {} {} {} {} {} {LY} Formic acid (ammonium) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Formic acid (ammonium) {} {} {} {} {} {} {} {} {} {} {LY} Formic acid (ammonium) {} {} {} {} {} {} {} {} {} {} {} {LY} Formic acid (ammonium) {} {} {} {} {} {} {} {} {} {} {} {} {LY} Formic acid (ammonium) {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Formic acid (ammonium) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Formic acid (ammonium) {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Formic aci
EC Number208-753-9
Merck Number14,523
Beilstein Registry Number3625095
Chemical Name Translation甲酸铵
Wiswesser Line NotationVHO &ZH
InChIInChI=1S/CH2O2.H3N/c2-1-3;/h1H,(H,2,3);1H3
Canonical SMILES[H]C(O[NH4])=O
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分类

  • {SNA} Analytical Reagents, Analytical/Chromatography, Buffers & Reagents, Chromatography Reagents & Solvents, HPLC, HPLC Buffer - Solid, HPLC Buffers, Solid
  • {SNA} Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents,
  • {SNA} Chromatography Reagents & Solvents, HybridSPE-Phospholipid Technology, LC-MS Mobile Phase Additives, LC-MS Solvents & Reagents (CHROMASOLV), Precipitation Solvents, Blends, Additives, Sample Preparation & Purification, Solid Phase Extraction (SPE), 分析/色谱, 分析试剂
  • {SNA} Essential Chemicals, Inorganic Salts, Solutions and Reagents, Reagent Grade, Research Essentials
  • {SNA} Chromatography Reagents & Solvents,

产品应用

  • 分析试剂,从贵金属盐中沉淀碱金属。
  • 缓冲液组分,用于在凝聚胺(polybrene)亲和层析从复杂系统中分离和纯化糖胺(glycosaminoglycans)

相关文献及参考

  • Merck:14,523 Beilstein: 2,IV,18
  • Reagent for N-formylation of secondary amines and anilines: Tetrahedron Lett., 41, 9149 (2000).
  • Widely used as a hydrogen donor in catalytic hydrogen transfer reductions. Review: Synthesis, 91 (1988). See also Palladium, A12012, Cyclohexene, A11359, Hydrazine monohydrate, A14005, Formic acid, A13285 and Sodium hypophosphite monohydrate, A13385.
  • Short: III/5a
  • A simple microwave-assisted method for catalytic transfer hydrogenation in ethylene glycol or 1,3-propanediol has been reported: J. Org. Chem., 64, 5746 (1999).
  • Examples include:
  • Reduction of aryl nitro groups to amines: Tetrahedron Lett., 25, 3415 (1984). For reductive cyclization of an o-nitrobenzyl ketone to an indole, see: Org. Synth. Coll., 9, 601 (1998). Hydrogenolysis of N-benzyl groups: Synthesis, 53 (1987); Tetrahedron Lett., 28, 515 (1987). Reduction of aldehydes and ketones to methyl and methylene groups: Tetrahedron Lett., 29, 3741 (1988). The temperature- and solvent-dependencies of this type of reaction have been studied: Synth. Commun., 22, 2673, 2683 (1992). Selective reduction of the heterocyclic ring of quinolines and isoquinolines: Synth. Commun., 20, 2815 (1990). Reduction of pyridine N-oxides to piperidines: J. Org. Chem., 66, 5264 (2001). Regioselective reduction of epoxides: J. Org. Chem., 60, 4922 (1995). Ammonium formate was found to be a more active H donor than either sodium formate or formic acid in the catalytic hydrogenolysis of aryl chlorides. For a comparative mechanistic study of this reaction, see: J. Org. Chem., 60, 1347 (1995).
  • Merck:14,523

安全信息

GHS Symbol
WGK Germany1
Hazard Codes Xi
Hazard statements
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Signal word Warning
RTECSBQ6650000
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S36 Wear suitable protective clothing 穿戴适当的防护服;
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
  • S37 Wear suitable gloves 戴适当手套;
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Storage condition Store at room temperature, keep dry and cool {LY} Store at room temperature, keep dry and cool {} {LY} Store at room temperature, keep dry and cool {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} { {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature, keep dry and cool {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 2250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZERNAL Zeitschrift fuer Ernaehrungswissenschaft.  (Dr. Dietrich Steinkopff
   Verlag, Postfach 111008, D-6100 Darmstadt 11, Fed. Rep. Ger.)  V.1- 1960- 
   Volume(issue)/page/year: 9,332,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 410 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ZERNAL Zeitschrift fuer Ernaehrungswissenschaft.  (Dr. Dietrich Steinkopff
   Verlag, Postfach 111008, D-6100 Darmstadt 11, Fed. Rep. Ger.)  V.1- 1960- 
   Volume(issue)/page/year: 9,332,1969

其他信息

  • 水中溶解度(g/100ml):不同温度(℃)时每100毫升水中的溶解克数: 102g/0℃;143g/20℃;204g/40℃;311g/60℃;533g/80℃
  • 毒性分级:中毒
  • 急性毒性:口服-小鼠LD50: 2250 毫克/公斤;静脉-小鼠LD50: 410 毫克/公斤
  • Alfa Aesar:甲酸铵,99% Ammonium formate, 99%(540-69-2)
  • 易潮解,易溶于水,能溶于醇、氨水
  • 用途四:分析试剂,从贵金属盐中沉淀碱金属。
  • 甲酸铵价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 30011618 甲酸铵;蚁酸铵 500g 47元 2011/08/23 30011628 甲酸铵;蚁酸铵 500g 41元 2010/06/21 168615000 甲酸铵 Ammonium formate 97% 500 GR 730元
  • 类别:有毒物品
  • 用途一:用于电解、电容器行业
  • 敏感性:Hygroscopic
  • MOL 文件:540-69-2.mol
  • 上游原料:氨 --> 甲酸 --> 4-氯苯甲醛
  • 储运特性:库房通风低温干燥
  • F:3-10
  • 易潮解,易溶于水,能溶于醇、氨水。
  • 可燃性危险特性:可燃; 高温产生有毒氮氧化物和氨烟雾
  • 下游产品:2,5-二甲氧基苄胺 --> 三唑酮 --> (1-甲基-2-哌啶)甲胺 --> 5-氮杂吲哚 --> 1,2,4-三氮唑 --> 3-吖丁啶羧酸 --> 5-氨基-2-吲哚 羧酸 --> N-Boc-3-羟基氮杂环丁烷 --> 3-氨基-5-氟吡啶 --> 5-氟-2-吡啶羧酸 --> 4-三氟甲基烟酸 --> 5-氨基-1H-吲哚-2-羧酸乙酯 --> 4-氯-7-甲基噻吩并[3,2-D]嘧啶 --> S-烯丙醇酮 --> 3-氨基-4-甲氧基苯甲酸 --> 3-(4-吗啉基)苯胺 --> 3-氯苄胺 --> 5-氯-1H-吲唑-3-乙酸 --> α-氨基乙苯 --> 1,3,5-三甲基-吡唑-4-甲胺 --> 4-甲基-5-甲酸基-1,3-噁唑 --> 4-甲基恶唑-5-羰酰氯 --> 3,5-双(三氟甲基)苯甲胺 --> 4-氯-2-甲基苄胺 --> 2,3-二羟基苯并[B]呋喃-5-基甲胺 --> 替考拉宁 A2 --> alpha-甲基苄胺 --> (R)-2-氨基庚烷 --> 3,4,5-三甲氧基苄胺 --> 吲唑-3-乙酸 --> 柠嗪酸 --> 香兰素胺盐酸盐 --> 4-氨基四氢吡喃
  • 图谱信息:甲酸铵(540-69-2)Raman光谱 甲酸铵(540-69-2)核磁图( 13 CNMR) 甲酸铵(540-69-2)红外图谱(IR1) 甲酸铵(540-69-2)红外图谱(IR2)
  • Acros Organics:甲酸铵 Ammonium formate, 99%(540-69-2)
  • Sigma Aldrich:540-69-2(sigmaaldrich)
  • 方法一:由甲酸和氨中和而得。将甲酸及水冷冻,搅拌下通氨气使pH值为7-7.5,降温至-5℃,甩滤,得甲酸铵。
  • 用途三:用于有机合成,作医药中间体、分析试剂。
  • 用途二:用作分析试剂,也用于有机合成
  • 灭火剂:干粉、泡沫、砂土、二氧化碳, 雾状水
  • MSDS 信息:Ammonium formate(540-69-2).msds

系列性分类


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