Eucalyptol 桉叶油素

CAS 470-82-6 MFCD00167977

化学结构图

470-82-6
SMILES: CC12CCC(CC1)C(C)(C)O2

化学属性

Mol. FormulaC10H18O
Mol. Weight154
Refractive indexn20/D 1.457(lit.)
Boiling Point176-177
Density0.921
Melting Point1-2
Flash Point48°C(lit.)
TSCAYes
Solubility微溶于水,可混溶于醇、氯仿、甘油。

别名和识别编码

Chemical NameEucalyptol
CAS Number470-82-6
Synonym 1 1,3,3-Trimethyl-2-oxabicyclo(2.2.2)octane 1,3,3-trimethyl-2-oxabicyclo(2.2.2)octan 1,3,3-三甲基-2- 1,3,3-三甲基-2-氧杂二环[2.2.2]辛烷 1,3,3-三甲基-2-氧杂二环[2.2.2]辛烷 1,8-桉叶素 1,8-环氧对孟烷 桉叶油醇 1,8,8-trimethyl-7-oxabicyclo[2.2.2]octane 1,8-CINEOLE 1,8-Cineole-d3 1,8-cineol (eucalyptol) 1,8-cineole 1,8-cineole (Eucalyptol) 2-Oxa-1,3,3-trimethylbicyclo[2.2.2]octane 8-环氧对孟烷 CINEOLE-1,8 Eucalyptol, 1,3,3-Trimethyl-2-oxabicyclo[2.2.2]octane, 1,8-Cineole LABOTEST-BB LT00440774 Limonene oxide Terpan Zineol eucalyptol {} {} {uni_hambu {} {} {uni_hamburg 桉叶油醇 桉叶素,桉叶油醇; 桉树脑; 1,8-环氧对孟烷; 欧卡那卜托; 1,3,3-三甲基-2-氧杂双环[2.2.2]辛烷 桉树脑 萜烷
PubChem Substance ID24893017
EC Number207-431-5
Beilstein Registry Number105109
MDL NumberMFCD00167977
Merck Number3895
Chemical Name Translation桉叶油素
Reaxys-RN105109
Wiswesser Line NotationT66 A B AOTJ B1 B1 F1
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分类

  • {Chemicalbook} 食品添加剂: 食用香料(增香剂): 天然等同香料和人造香
  • {SNA} A - D, Achillea, Alphabetical, Analytical Standards, Analytical/Chromatography, Artemisia, Chromatography, Cinnamomum, Curcuma, Eucalyptus, Isoprenoids, Lavandula,

产品应用

  • The chief constituent of oil of eucalyptus. Used as pharmaceutic aid (flavor).

相关文献及参考

  • [2]. Zeraatpisheh Z, et al. Eucalyptol induces hyperexcitability and epileptiform activity in snail neurons by inhibiting potassium channels. Eur J Pharmacol. 2015 Oct 5;764:70-8.
  • [3]. Khan A, et al. 1,8-cineole (eucalyptol) mitigates inflammation in amyloid Beta toxicated PC12 cells: relevance to Alzheimer's disease. Neurochem Res. 2014 Feb;39(2):344-52.[3]
  • [4]. Caldas GF, et al. Repeated-doses and reproductive toxicity studies of the monoterpene 1,8-cineole (eucalyptol) in Wistar rats. Food Chem Toxicol. 2016 Nov;97:297-306.
  • Jori, et al.: Eur. J. Pharmacol., 9, 362 (1970),
  • Maugh, T.H., Science, 218, 278 (1982),
  • Merck: 14,3895
  • Merck: 14,3895 Beilstein: 17,V,1,273
  • Short: II/27B
  • [1]. Jarvis GE, et al. Nonco
  • [1]. Jarvis GE, et al. Noncompetitive Inhibition of 5-HT3 Receptors by Citral, Linalool, and Eucalyptol Revealed by Nonlinear Mixed-Effects Modeling. J Pharmacol Exp Ther. 2016 Mar;356(3):549-62.

安全信息

GHS Symbol
WGK Germany2
Hazard Codes 3
Hazard statements
  • H226 Flammable liquid and vapour 易燃液体和蒸气
Signal word Warning
RTECSOS9275000
Packing GroupIII
UN Number 1993 UN3271
Risk Statements
  • R10 Flammable 易燃
Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Safety Statements
  • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
  • S39 Wear eye/face protection 戴眼睛/面孔保护装置;
Precautionary statements
  • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
  • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P303+P361+P353
  • P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适,呼叫解毒中心或医生/医师。
  • P370+P378
  • P403+P235
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard Class3
Storage condition 2-8°C
Warnings 危化品目录(2015)
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2480 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Behavioral - coma
REFERENCE :
   FCTXAV Food and Cosmetics Toxicology.  (London, UK)  V.1-19, 1963-81.  For
   publisher information, see FCTOD7.  Volume(issue)/page/year: 2,327,1964

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 2250 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
   TFAKA4 Trudy Instituta Fiziologii, Akademiya Nauk Kazakhshoi SSR.
   Transactions of the Institute of Physiology, Academy of Sciences of the
   Kazakh. SSR.  (Izdatel'stvo Nauka Kazakhskoi SSR, Alma- Ata, USSR)  V.1-
   1955-  Volume(issue)/page/year: 1,134,1955

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1070 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - spastic paralysis with or without sensory
   change
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   SIZSAR Sapporo Igaku Zasshi.  Sapporo Medical Journal.  (Sapporo Igaku
   Daigaku, Nishi-17-chome, Minami-1-jo, Chuo-ku, Sapporo 060, Japan)  V.3-
   1952-  Volume(issue)/page/year: 3,73,1952

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intramuscular
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JSICAZ Journal of Scientific and Industrial Research, Secti

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Rodent - hamster Ovary
DOSE/DURATION           : 200 mg/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   10(Suppl 10),1,1987

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 2 gm/kg
SEX/DURATION            : female 19-22 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - biochemical and metabolic
REFERENCE :
   BCPCA6 Biochemical Pharmacology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.1-    1958-  Volume(issue)/page/year:
   22,543,1973

Restrict 危险品

其他信息

  • Alfa Aesar:桉树脑,99% 1,8-Cineole, 99%(470-82-6)
  • 用途一:是薰衣草油和穗薰衣草油的固有成分之一,是配制这类精油必用的香料。适量用于药草型如薰衣草、新刈草和香薇型香精中,有增加成鲜的效果。用于药皂、喷雾剂或化妆品香精和其他卫生用品,如牙膏等,有杀菌作用。工业制品中可用作不良气息的掩盖剂。也用于食用香精。
  • FEMA:2465
  • 毒性分级:中毒
  • 参考质量标准:FCC,1997 含量 ≥98.5% 折射率n D 20 1.455~1.460 相对密度d 25 25 0.921~0.924 旋光度[α] D 20 -0.5°~+5° QB T 2243—96 色状 无色液体 香气 樟脑样茅香及强烈刺激性凉味 d 25 25 0.920~0.925 n D 20 1.455~1.460 [α] D 25 -0.5°~+0.5° 溶解度(25℃) lml溶于5ml以上60%(V/V)乙醇中 冻点A等 ≥0.8℃(相当于桉叶素含量≥99%)
  • {Chemical
  • 桉叶油醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80064761 桉叶油醇 100ml 24元 2011/04/16 C0934 1,8-桉树脑 1,8-Cineole 25ML 208元 2011/04/16 C0934 1,8-桉树脑 1,8-Cineole 500ML 987元
  • 桉叶油醇价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2011/08/23 80064761 桉叶油醇 100ml 24元 2011/04/16 C0934 1,8-桉树脑 1,8-Cineole 25ML 208元 2011/
  • Alfa Aesar:桉树脑,99% 1,8-C
  • 灭火剂:干粉、干砂、二氧化碳、泡沫、1211灭火剂
  • TCI Shanghai:1,8-桉树脑[用于邻甲酚的测定] 1,8-Cineole [for Determination of o-Cresol],>;99.0%(GC)(470-82-6)
  • 上游原料:桉叶油 --> 萜品 --> 桉叶醇
  • 使用限量:FEMA(mg/kg):软饮料0.13;冷饮0.50;糖果1 5;焙烤食品0.50~4.0;胶姆糖190。 适度为限(FDA§172.515,2000)。
  • 方法二:桉树脑广泛存在于天然芳香油中,为桉叶油的主要成分。桉树脑可以芳香油中单离制得。例如将桉叶油分馏,收集175-180℃馏分,稍加精制即可。如需制造纯度较高的产品,可将芳香油中分
  • 用途二:GB 2760一9
  • 类别:易燃液体
  • 溶于12-15倍容积的50%乙醇,4倍的60%乙醇,1.5-2倍的71%乙醇,溶于氯仿、乙酸及挥发油,微溶于乙醚,具有樟脑样香气和
  • Acros Organics:桉油精 Cineole, 99%(470-82-6)
  • 溶于12-15倍容积的50%乙醇,4倍的60%乙醇,1.5-2倍的70%乙醇,
  • 急性毒性:口服- 大
  • 含量分析:邻甲酚的制备 凝固点不低于30℃。应用时需经蒸馏,取190~192℃的馏分,盛于干燥玻塞瓶中备用。在应用前需用100%纯桉叶素校核其凝固点应为55.2℃。 操作准确称取邻甲酚2.1 g(士0.002 g),放入内径15~20 mrn硬质试管中,再将试管放入直径30~40mm套管中,插入精密温度计,搅拌至完全凝固,记下回升到最高点的温度。取出试管,放于热水中搅动,使熔化后再将试管放入套管中,并将套管放于1L烧杯,烧杯内盛有低于预计凝固点5~10℃的水。当冷却至试管中已有细微结晶,或已冷却至预计凝固点时,即加速搅拌,使其迅速凝固。记下回升至最高点的温度。再如上重复熔化后再放入套管中,冷却至较第二次测得温度低1~2℃时,即开始搅拌如前,读取回升至最高点的温度,直至两次结果相差不超过0.1℃时为止,按表03554求取桉叶素含量百分率
  • MSDS 信息:桉叶油醇(470-82-6).msds

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