1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺

CAS 1892-57-5 MFCD00044916

化学结构图

1892-57-5
SMILES: CCN=C=NCCCN(C)C

化学属性

Mol. FormulaC8H17N3
Mol. Weight155.24
Refractive index1.4590 to 1.4630
Density0.877
Flash Point>110°(230°F)
TSCAYes
Boiling Point197.7°C at 760 mmHg
Stability对空气和热敏感,易吸湿

别名和识别编码

Chemical Name1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide
Reaxys-RN507429
CAS Number1892-57-5
PubChem Substance ID15908
MDL NumberMFCD00044916
Synonym N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine {LY} N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine {} {LY} N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine {} {} {LY} N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine {} {} {} {LY} N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine {} {} {} {} {LY} N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine {} {} {} {} {} {LY} N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine {} {} {} {} {} {} {LY} N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine {} {} {} {} {} {} {} {LY} N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine {} {} {} {} {} {} {} {} {LY} N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine {} {} {} {} {} {} {} {} {} {LY} N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine {} {} {} {} {} {} {} {} {} {} {LY} N1-((Ethylimino)methylene)-N3,N3-dimethylpropane-1,3-diamine {} {} {} {} {} {} {} {} {} {}
EC Number217-579-2
Beilstein Registry Number507429
Alfabeta NameDIMETHYLAMINOPROPYLETHYLCARBODIIMIDE NN3[]()----'
Chemical Name Translation1-(3-二甲基氨基丙基)-3-乙基碳二亚胺
LabNetwork Molecule IDLN00185247
InChIInChI=1S/C8H17N3/c1-4-9-8-10-6-5-7-11(2)3/h4-7H2,1-3H3
Canonical SMILESCN(C)CCCN=C=NCC
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分类

  • {SNA} Carbodiimides, Chemical Biology, Chemical Synthesis, Coupling, Peptide Chemistry, Peptide Coupling, Synthetic Reagents

产品应用

  • An agent used to activate carboxylic acids for ester or amide formation.

相关文献及参考

  • Free base form of 'Water-soluble' carbodiimide. For applications see following entry. In the presence of CuCl2, (E)- or (Z)-2-substituted 3-hydroxy-3-phenylpropionate esters can be dehydrated stereoselectively to the corresponding (E) or (Z)-cinnamates: Tetrahedron Lett., 40, 5019 (1999).
  • Merck: 14,10328

安全信息

UN Number
Signal word Danger
Precautionary statements
  • P233 Keep container tightly closed. ?保持容器密闭。
  • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
  • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
  • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
  • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
  • P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
  • P273 Avoid release to the environment. 避免释放到环境中。
  • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
  • P284 Wear respiratory protection.? 佩戴呼吸保护装置。
  • P285 In case of inadequate ventilation wear respiratory protection. 在通风不足的情况下，戴呼吸防护。
  • P301+P312
  • P301+P317
  • P301+P330+P331
  • P301+P330+P331+P310
  • P302+P352
  • P302+P361+P354
  • P303+P361+P353
  • P303+P361+P353+P310+P363
  • P304+P340
  • P304+P340+P310
  • P304+P341
  • P305+P351+P338
  • P305+P351+P338+P310
  • P305+P354+P338
  • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
  • P316
  • P319
  • P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。
  • P330 Rinse mouth. 漱口
  • P332+P317
  • P333+P313
  • P333+P317
  • P342+P311
  • P342+P316
  • P361+P364
  • P362+P364
  • P363 Wash contaminated clothing before reuse. 被污染的衣服洗净后方可重新使用。
  • P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
  • P403 Store in a well-ventilated place. 储存在通风良好的地方。
  • P405 Store locked up. 上锁保管。
  • P501 Dispose of contents/container to..… 处理内容物/容器.....
Storage condition -20°C, stored under nitrogen {LY} -20°C, stored under nitrogen <0°C <;0 Air & Moisture Sensitive {} {LY} -20°C, stored under nitrogen {} {} {LY} -20°C, stored under nitrogen {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} -20°C, stored under ni
Hazard statements
  • H302 Harmful if swallowed 吞食有害
  • H311 Toxic in contact with skin 皮肤接触中毒
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H315 Causes skin irritation 会刺激皮肤
  • H317 May cause an allergic skin reaction 可能导致皮肤过敏
  • H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
  • H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
  • H410 Verytoxictoaquaticlifewithlonglastingeffects 对水生生物毒性非常大并具有长期影响。
Risk Statements
  • R34 Causes burns 会导致灼伤
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
GHS Symbol
WGK Germany3
Hazard Codes
Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Packing GroupIII
Warnings IRRITANT
Hazard Class8

其他信息

  • 敏感性:Air Sensitive
  • 上游原料:乙醚 --> 二氯甲烷 --> 碳酸钾 --> 三乙胺 --> 4-甲苯磺酰氯 --> N,N-二甲基-1,3-二氨基丙烷 --> 异氰酸乙酯
  • Alfa Aesar:1-（3-二甲基氨丙基）-3-乙基碳酰亚胺,98% 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98%(1892-57-5)
  • 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2010/05/25 B25057 1-（3-二甲基氨丙基）-3-乙基碳酰亚胺,98% 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98% 5g 812元 2010/05/25 B25057 1-（3-二甲基氨丙基）-3-乙基碳酰亚胺,98% 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98% 25g 2912元 2010/05/25 B25057 1-（3-二甲基氨丙基）-3-乙基碳酰亚胺,98% 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98% 100g 10780元
  • F:1-3-10
  • MOL 文件:1892-57-5.mol
  • Sigma Aldrich:1892-57-5(sigmaaldrich)

系列性分类

  1. Chemical Synthesis 化学合成
  2. Synthetic Reagents 合成试剂
  3. Coupling - Synthetic Reagents
  4. Carbodiimides - Coupling
  1. Chemical Synthesis 化学合成
  2. Building Blocks 合成砌块
  3. Organic Building Blocks 有机砌块
  4. Nitrogen Compounds 氮化合物
  5. Amidates/Imidates - Nitrogen Compounds
  1. Chemical Synthesis 化学合成
  2. Chemical Biology 生物化学
  3. Peptide Chemistry 多肽化学
  4. Peptide Coupling - Peptide Chemistry
  5. Carbodiimides - Peptide Coupling