CAS 1675-54-3 MFCD00080480-2,2-Bis(4-glycidyloxyphenyl)propane 2,2-双(4-环氧丙氧基苯基)丙烷 TAO{mole}

2,2-Bis(4-glycidyloxyphenyl)propane 2,2-双(4-环氧丙氧基苯基)丙烷

CAS 1675-54-3 MFCD00080480

化学结构图

SMILES: CC(C)(c1ccc(OCC2CO2)cc1)c1ccc(OCC2CO2)cc1

化学属性

Mol. Formula	C21H24O4
Mol. Weight	340.42
Melting Point	40-44 °C
Refractive index	1.5720 to 1.5750
Density	1.16 g/mL at 25 °C(lit.)
TSCA	Yes
Boiling Point	210 °C at 1 mmHg
Solubility	Soluble in 100% ethanol, DMSO (100 mM), DMF, chloroform, methanol, and ethanol (50 mM). Insoluble in PBS, pH 7.2, and water.
Stability	对热、湿度敏感

别名和识别编码

Chemical Name	2,2-Bis(4-glycidyloxyphenyl)propane
Synonym	Bisphenol A diglycidyl ether {LY} Bisphenol A diglycidyl ether {} {LY} Bisphenol A diglycidyl ether {} {} {LY} Bisphenol A diglycidyl ether {} {} {} {LY} Bisphenol A diglycidyl ether {} {} {} {} {LY} Bisphenol A diglycidyl ether {} {} {} {} {} {LY} Bisphenol A diglycidyl ether {} {} {} {} {} {} {LY} Bisphenol A diglycidyl ether, 85% {} {} {} {} {} {} {} {LY} Bisphenol A diglycidyl ether, 85% {} {} {} {} {} {} {} {} {LY} Bisphenol A diglycidyl ether, 85% {} {} {} {} {} {} {} {} {} {LY} Bisphenol A diglycidyl ether, 85% {} {} {} {} {} {} {} {} {} {} {LY} Bisphenol A diglycidyl ether, 85% {} {} {} {} {} {} {} {} {} {} {} {LY} Bisphenol A diglycidyl ether, 85% {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bisphenol A diglycidyl ether, 85% {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bisphenol A diglycidyl ether, 85% {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bisphenol A diglycidyl ether, 85% {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Bisphenol A diglycidyl ether
CAS Number	1675-54-3
PubChem Substance ID	2286
EC Number	216-823-5
Beilstein Registry Number	299026
MDL Number	MFCD00080480
Reaxys-RN	299026
Chemical Name Translation	2,2-双(4-环氧丙氧基苯基)丙烷
Wiswesser Line Notation	T3OTJ B1OR D- 2X
LabNetwork Molecule ID	LN01277313
InChI	InChI=1S/C21H24O4/c1-21(2,15-3-7-17(8-4-15)22-11-19-13-24-19)16-5-9-18(10-6-16)23-12-20-14-25-20/h3-10,19-20H,11-14H2,1-2H3
Canonical SMILES	CC(C1=CC=C(OCC2OC2)C=C1)(C3=CC=C(OCC4OC4)C=C3)C

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

An inhibitor of PPARγ and suppressor of TNFα.

安全信息

GHS Symbol

WGK Germany1

Hazard Codes Xi

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H319 Causes serious eye irritation 严重刺激眼睛

Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter dust mask type N95 (US), Eyeshields, Faceshields, Gloves

RTECSTX3800000

Precautionary statements

P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
P302+P352+P333+P313+P362+P364
P333+P313
P305+P351+P338
P501 Dispose of contents/container to..… 处理内容物/容器.....
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P302+P350
P337+P313
P272 Contaminated work clothing should not be allowed out of the workplace. 污染的工作服不得带出工作场所。
P305+P351+P338+P337+P313

Signal word Warning {} {} {} {} {TCI}

Risk Statements

R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应

Safety Statements

S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护；
S2 Keep out of the reach of children 避免儿童触及；
S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后，立即用大量…（由生产厂家指定）冲洗；

Storage condition Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 166 gm/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Endocrine - thyroid tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   26,611,1988

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 312 gm/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Reproductive - Tumorigenic effects - ovarian tumors
REFERENCE :
   CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut
   Sts., Philadelphia, PA 19106)  V.1-    1941-  Volume(issue)/page/year:
   39,1718,1979

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Administration onto the skin
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 312 gm/kg/2Y-I
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   NTIS** National Technical Information Service.  (Springfield, VA 22161)
   Formerly U.S. Clearinghouse for Scientific & Technical Information.
   Volume(issue)/page/year: ORNL-5375

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 15600 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolen

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 11300 uL/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   UCDS** Union Carbide Data Sheet.  (Union Carbide Corp., 39 Old Ridgebury
   Rd., Danbury, CT 06817)  Volume(issue)/page/year: 4/21/1967

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2200 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
   Volume(issue)/page/year: 2A,2219,1981

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 1980 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Gastrointestinal - hypermotility, diarrhea
   Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
   38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton,
   G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82.
   Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
   Volume(issue)/page/year: 2A,2219,1981

{haza

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 33 ug/plate
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 172,105,1986

其他信息

Bisphenol A Diglycidyl Ether is a diglycidyl ether (BADGE) can inhibit the peroxisome proliferator-activated receptor (PPARγ) and adipocyte differentiation, and has been shown to induce apoptosis in tumor cells. Research shows that BADGE can suppress the tumor necrosis factor-α (TNF-α) and that it has the ability to induce F-actin depolymerization.