CAS 141-90-2 MFCD00006039-2-Thiouracil 2-硫脲嘧啶 TAO{mole}

2-Thiouracil 2-硫脲嘧啶

CAS 141-90-2 MFCD00006039

化学结构图

SMILES: O=c1cc[nH]c(=S)[nH]1

化学属性

Mol. Formula	C4H4N2OS
Mol. Weight	128.15
Density	1.46
Melting Point	>300°C
TSCA	Yes
Solubility	0.5 G/L

别名和识别编码

Chemical Name	2-Thiouracil
CAS Number	141-90-2
Alfabeta Name	THIOURACIL 2-
MDL Number	MFCD00006039
Synonym	2-Thiouracil {LY} 2-Thiouracil {} {LY} 2-Thiouracil {} {} {LY} 2-Thiouracil {} {} {} {LY} 2-Thiouracil {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {} {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-Thiouracil {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {
EC Number	205-508-8
Beilstein Registry Number	112227
Merck Number	9366
PubChem Substance ID	1269845
Reaxys-RN	112227
Chemical Name Translation	2-硫脲嘧啶
Wiswesser Line Notation	T6MYMVJ BUS
LabNetwork Molecule ID	LN00174819
InChI	InChI=1S/C4H4N2OS/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
Canonical SMILES	O=C(C=CN1)NC1=S

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

Reagent used in the preparation of Antithyroid agents.

安全信息

Warnings IRRITANT

Signal word Warning

GHS Symbol

WGK Germany3

Safety Statements

S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Risk Statements

R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用

Precautionary statements

P201 Obtain special instructions before use. 使用前获取专门指示。
P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P273 Avoid release to the environment. 避免释放到环境中。
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P281 Use personal protective equipment as required. 使用所需的个人防护装备。
P305+P351+P338
P308+P313
P391 Collect spillage. Hazardous to the aquatic environment 收集对水环境有危害的泄漏物。
P405 Store locked up. 上锁保管。
P501 Dispose of contents/container to..… 处理内容物/容器.....

Hazard statements

H351 Suspected of causing cancer 怀疑致癌
H303 May be harmfully swallowed 吞食可能有害

RTECSYR1575000

Personal Protective Equipment Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

Hazard Codes Xn

Storage condition 2-8°C {LY} 2-8°C {} {LY} 2-8°C {} {} {LY} 2-8°C {} {} {} {LY} 2-8°C {} {} {} {} {LY} 2-8°C {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {

Hazard Class9

UN Number 3077

Packing GroupIII

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 gm/kg/14W-C
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Endocrine - thyroid weight (goiter)
   Tumorigenic - increased incidence of tumors in susceptible strains
REFERENCE :
   CANCAR Cancer (Philadelphia).  (Lippincott/Harper, Journal Fulfillment
   Dept., 2350 Virginia Ave., Hagerstown, MD 21740)  V.1-    1948-
   Volume(issue)/page/year: 6,111,1953

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 184 gm/kg/73W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   PSEBAA Proceedings of the Society for Experimental Biology and Medicine.
   (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)  V.1-    1903/04-
   Volume(issue)/page/year: 113,493,1963

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 3900 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JAPMA8 Journal of the American Pharmaceutical Association, Scientific
   Edition.  (Washington, DC) V.29-49, 1940-60.  For publisher information, see
   JPMSAE.  Volume(issue)/page/year: 44,56,1955

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 1500 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   JPETAB Journal of Pharmacology and Experimental Therapeutics.  (Williams &
   Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)  V.1-    1909/10-
   Volume(issue)/page/year: 97,478,1949

TYPE OF TEST            : Phage inhibition capacity
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 100 mmol/L
REFERENCE :
   MDMIAZ Medycyna Doswiadczalna i Mikrobiologia.  For English translation, see
   EXMMAV.  (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland)  V.1-    1949-
   Volume(issue)/page/year: 31,11,1979

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 1600 mg/kg
SEX/DURATION            : female 1-16 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   ENDOAO Endocrinology (Baltimore).  (Williams & Wilkins Co., 428 E. Preston
   St., Baltimore, MD 21203) V.1-    1917-  Volume(issue)/page/year:
   45,389,1949

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 484 mg/kg
SEX/DURATION            : female 1-26 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - endocrine system
REFERENCE :
   LANCAO Lancet.  (7 Adam St., London WC2N 6AD, UK)  V.1-    1823-
   Volume(issue)/page/year: 1,1281,1953

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 22750 mg/kg
SEX/DURATION            : female 91 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - endocrine system
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
REFERENCE :
   ANREAK Anatomical Record.  (Alan R. Liss, Inc., 41 E. 11th St., New York, NY
   10003)  V.1-    1906/08-  Volume(issue)/page/year: 109,318,1951

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Human - woman
DOSE                    : 924 mg/kg
SEX/DURATION            : female 26-41 week(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - craniofac

其他信息

Alfa Aesar:2-硫代尿嘧啶,98% 2-Thiouracil, 98%(141-90-2)
海关编码:29335995
MSDS 信息:4-Hydroxy-2-mercaptopyrimidine(141-90-2).msds
图谱信息:2-硫脲嘧啶(141-90-2)核磁图( 13 CNMR) 2-硫脲嘧啶(141-90-2)核磁图( 1 HNMR) 2-硫脲嘧啶(141-90-2)红外图谱(IR1) 2-硫脲嘧啶(141-90-2)质谱(MS) 2-硫脲嘧啶(141-90-2)红外图谱(IR2)
水中溶解度:0.5 g/L，溶于碱液。
Acros Organics:2-硫脲嘧啶 2-Thiouracil, 99%(141-90-2)
MOL 文件:141-90-2.mol
检测方法:HPLC
2-硫脲嘧啶价格(试剂级):更新日期产品编号产品名称包装价格 2014/06/02 T0224 2-硫脲嘧啶 2-Thiouracil 250G 1130元 2014/06/02 T0224 2-硫脲嘧啶 2-Thiouracil 25G 192元 2010/06/21 151845000 2-硫脲嘧啶 2-Thiouracil 99% 500 GR 2775元
用途一:用作医药中间体
上游原料:甲醇钠 --> 硫脲
Sigma Aldrich:141-90-2(sigmaaldrich)
下游产品:4(3H)-嘧啶酮 --> 4-硫尿嘧啶 --> 4-氯-2-甲磺酰基嘧啶 --> 2-甲硫基-4-嘧啶酮 --> 4-氯-5-溴-2-甲磺酰基嘧啶 --> 2-甲硫基-4-氯-5-溴嘧啶 --> 嘧啶-4-醇 --> 4-嘧啶酮 --> 4-溴嘧啶 --> 4-氯-N-甲基嘧啶-2-胺 --> 2-甲硫基-4-苯甲氨基嘧啶 --> 2-甲硫基-4-氯嘧啶
TCI Shanghai:2-硫代脲嘧啶 2-Thiouracil,>;98.0%(LC)(T)(141-90-2)