6-Methyl-2-thiouracil 甲基硫脲嘧啶
CAS 56-04-2 MFCD00006040
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- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Analytical/Chromatography, Antibiotics, Chemical Structure, Chromatography, Clinical Standards,
- {SNA} Building Blocks, C4 to C5, Chemical Synthesis, Heterocyclic Building Blocks, Pyrimidines
- {SNA} Alphabetical Index of Analytical Standards, Analytical Standards, Antibiotics, Chemical Structure, Chromatography,
- {SNA} Additional Standards, Analytical Standards, Antibiotics Standards, Chemical Structure, Chromatography, Clinical Standards, Other Standards by Chemical Structure, Pharmaceuticals, Illicit Drugs & Alcohol, 分析/色谱
- {S
产品应用
- 心血管药物潘生丁的中间体。
相关文献及参考
- Merck:14,6128
- Merck:14,6128 Beilstein:24(3/4)1289
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- H351 Suspected of causing cancer 怀疑致癌
- P201 Obtain special instructions before use. 使用前获取专门指示。
- P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P281 Use personal protective equipment as required. 使用所需的个人防护装备。
- P301+P312+P330
- P305+P351+P338
- P308+P313
- P405 Store locked up. 上锁保管。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
- R22 Harmful if swallowed 吞咽有害
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 196 gm/kg/1Y-C TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Endocrine - thyroid tumors REFERENCE : CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948- Volume(issue)/page/year: 40,2188,1977
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 27783 mg/kg/60W-I TOXIC EFFECTS : Tumorigenic - neoplastic by RTECS criteria Endocrine - thyroid tumors REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 4,223,1950
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 9100 mg/kg/2Y-C TOXIC EFFECTS : Tumorigenic - Carcinogenic by RTECS criteria Endocrine - thyroid tumors REFERENCE : CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 19,870,1959
TYPE OF TEST : TD - Toxic dose (other than lowest) ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 53750 mg/kg/65W-I TOXIC EFFECTS : Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - thyroid tumors REFERENCE : BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947- Volume(issue)/page/year: 7,181,1953
TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE/DURATION : 2500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : 85KYAH "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989 Volume(issue)/page/year: 11,963,1989
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 1500 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869- Volume(issue)/page/year: 157,659,1946
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 920 mg/kg TOXIC EFFECTS : Lungs, Thorax, or Respiration - other changes REFERENCE : FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 13,882,1958
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 200 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE : 10 mg/kg SEX/DURATION : female 9 day(s) after conception TOXIC EFFECTS : Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system REFERENCE : KAIZAN Kaibogaku Zasshi. Journal of Anatomy. (Nippon Kaibo Gakkai, c/o Tokyo Daigaku Igakubu, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1928- Volume(issue)/page/year: 42,90,1967
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rabbit DOSE : 900 mg/kg SEX/DURATION : female 1-18 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - endocrine system REFERENCE : OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher information, see OIGZDE. Volume(issue)/page/year: 8,1281,1959
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE : 375 mg/kg SEX/DURATION : female 10-16 day(s) after conception TOXIC EFFECTS : Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Effects on Newborn - behavioral REFERENCE : ZYDXEN Zhongguo Yike Daxue Xuebao. Journal of China Medical University. (China International Book Trading Corp. POB 399, Beijing 100044, Peop. Rep. China) V.1- 19??-m/* Volume(issue)/page/year: 21,349,1992
TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Unreported SPECIES
其他信息
- 用途一:心血管药物潘生丁的中间体。
- 上游原料:碳酸钠 --> 氧化钠
- 方法一:由乙酰乙酸乙酯与硫脲反应而得。将硫脲溶解于氢氧化钠溶液中,滴加乙酰乙酸乙酯,控制温度在37℃以下。反应2h后,加水和活性炭,在70-80℃脱色0.5h。过滤,滤液用盐酸酸化至pH4-5,冷却至室温,过滤,洗涤。滤饼用水重结晶,得成品。收率66%。生产中,也可先将乙酰乙酸乙酯和硫脲混合,再滴加氧化钠溶液;还可用无水碳酸钠代替氢氧化钠,收率大致相同。
- Sigma Aldrich:56-04-2(sigmaaldrich)
- 在326-331℃分解,易溶于氨溶液及氢氧化钠溶液,微溶于醇、醚和丙酮,极微溶于水和醚,不溶于苯和氯仿,饱和水溶液对石蕊呈中性或微酸性,无气味,味苦,易升华。
- TCI Shanghai:6-甲基-2-硫尿嘧啶 6-Methyl-2-thiouracil,>;98.0%(T)(56-04-2)
- 图谱信息:甲基硫脲嘧啶(56-04-2)红外图谱(IR1) 甲基硫脲嘧啶(56-04-2)红外图谱(IR2) 甲基硫脲嘧啶(56-04-2)质谱(MS) 甲基硫脲嘧啶(56-04-2)核磁图( 1 HNMR)
- Hazard Note:Irritant/Possible Carcinogen
- 海关编码:29335995
- 检测方法:HPLC
- MOL 文件:56-04-2.mol
- Alfa Aesar:4-羟基-2-巯基-6-甲基嘧啶,98% 6-Methyl-2-thiouracil, 98%(56-04-2)
- 存储注意事项:光敏感
- MSDS 信息:Methylthiouracil(56-04-2).msds
- Acros Organics:4-羟基-2-巯基-6-甲基嘧啶 4-Hydroxy-2-mercapto-6-methylpyrimidine, 98%(56-04-2)
- 甲基硫脲嘧啶价格(试剂级):更新日期 产品编号 产品名称 包装 价格 2014/06/02 M0443 6-甲基-2-硫尿嘧啶 6-Methyl-2-thiouracil 500G 1940元 2014/06/02 M0443 6-甲基-2-硫尿嘧啶 6-Methyl-2-thiouracil 25G 253元 2010/06/21 121301000 甲基硫脲嘧啶 4-Hydroxy-2-mercapto-6-methylpyrimidine 98% 100 GR 292元