CAS 107-13-1 MFCD00001927-Acrylonitrile 丙烯腈 TAO{mole}

Acrylonitrile 丙烯腈

CAS 107-13-1 MFCD00001927

化学结构图

SMILES: C=CC#N

化学属性

Mol. Formula	CH2=CHCN
Mol. Weight	53.06
Refractive index	n20/D 1.391(lit.)
Boiling Point	77 °C(lit.)
Melting Point	-83 °C(lit.)
Density	1.0
Flash Point	-5 ºC
TSCA	Yes
Autoignition Point	897 °F
Vapor Density	1.83 (vs air)
Vapor Pressure	86 mmHg ( 20 °C)
Solubility	微溶于水，易溶于多数有机溶剂。
Stability	对光线敏感

别名和识别编码

Chemical Name	Acrylonitrile
CAS Number	107-13-1
Synonym	{uni_hamburg} 丙烯腈 2-丙烯腈乙烯基氰氰(代)乙烯 Acritet VCN 丙烯腈(剧毒不能订购) Propenenitrile Carbacryl 丙烯腈(剧毒) Cyanoethylene Acrylsäurenitril Akrylonitryl Acrylonitrile Fumigrain Miller's fumigrain 丙烯睛(AN) prop-2-enenitrile acrylonitrile(dot) Vinylkyanid CYANOETHYLENE acrylnitril(german,dutch) Vinyl Cy Acrylsäure-nitril Vinylcyanide Acrylsαurenitril Vinylcyanid 丙烯腈, 99+%, 大约40PPM的4-甲氧基苯酚作稳定剂 PROPENITRILE acrylonitrilemonomer cyanoethylene Propenitrile 2-Propenenitrile; Cyanoethylene acrylnitrile propenenitrile ACRYLIC ACID NITRILE Acrylonitrile monomer Cyanoethene Akrylonitril {Che ai3-00054 2-Propenenitrile Acrylonitrile, inhibited 2-propenenitrile 丙烯腈;氰乙烯;氰代乙烯;乙烯基氰;氰(基)乙烯 TL 314 VINYL CYANIDE 氰(基)乙烯谷粒熏蒸剂 vinyl cyanide 乙烯基腈 Ventox 2-Propennitril NSC 6362 Acrylnitril ENT 54 Nitrile acrilico C₃H₃N (acrylonitrile) acrylonitrile,inhibited ACRYLONITRILE 丙烯氰 051-01 [3,6] Acrylon 氰乙烯 Cianuro di vinile Vinyl cyanide Cyanure de vinyle Miller's fumigrain {hazard
EC Number	203-466-5
Beilstein Registry Number	605310
MDL Number	MFCD00001927
PubChem Substance ID	7855
Merck Number	14,131
Chemical Name Translation	丙烯腈
Wiswesser Line Notation	NC1U1
LabNetwork Molecule ID	LN00198150
InChI	InChI=1S/C3H3N/c1-2-3-4/h2H,1H2

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产品应用

校准仪器和装置；评价方法；工作标准；质量保证/质量控制；其他。

安全信息

GHS Symbol

WGK Germany3

Hazard Codes F;T;N F,T,N

Hazard statements

H315 Causes skin irritation 会刺激皮肤
H317 May cause an allergic skin reaction 可能导致皮肤过敏
H311 Toxic in contact with skin 皮肤接触中毒
H301 Toxic if swallowed 吞食有毒
H335 May cause respiratory irritation 可能导致呼吸道刺激
H350 May cause cancer 可能致癌
H411 Toxictoaquaticlifewithlonglastingeffects 对水生生物有毒性并具有长期影响。
H318 Causes serious eye damage 严重伤害眼睛
H331 Toxic if inhaled 吸入中毒
H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
H301+H311+H331
H361 Suspected of damaging fertility or the unborn child 怀疑对生育能力或未出生婴儿造成伤害

Personal Protective Equipment Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter

RTECSAT5250000

Precautionary statements

P273 Avoid release to the environment. 避免释放到环境中。
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
P301+P310
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
P201 Obtain special instructions before use. 使用前获取专门指示。
P301+P310+P330
P308+P313
P305+P351+P338+P310
P403+P233

Signal word Danger

UN Number UN1093 1093 UN 1093 3/PG 1

Risk Statements

R11 Highly flammable 非常易燃
R23/24/25 Toxic by inhalation, in contact with skin and if swallowed 吸入，皮肤接触及吞食都有毒
R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
R45 May cause cancer 可能致癌
R43 May cause sensitisation by skin contact 皮肤接触会产生过敏反应
R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
R62 Possible risk of impaired fertility 有削弱生殖能力的危险
R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
R51/53
R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险

Safety Statements

S9 Keep container in a well-ventilated place 保持容器在通风良好的场所；
S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；

Storage condition 本品属易燃、易爆、剧毒品。运输和贮存均应隔绝热源及火源,贮存于干燥、通风、低温的仓库中。 Light Sensitive 储存温度2-8℃ 2-8°C

Packing GroupI

Hazard Class3

Restrict 剧毒

Warnings 危化品目录(2015)

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 5 ppm/52W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Skin and Appendages - tumors
REFERENCE :
   MELAAD Medicina del Lavoro.  Industrial Medicine.  (Via S. Barnaba, 8, 20122
   Milan, Italy) V.16-    1925-  Volume(issue)/page/year: 68,401,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18200 mg/kg/52W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Brain and Coverings - tumors
REFERENCE :
   FCTOD7 Food and Chemical Toxicology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.20-    1982- Volume(issue)/page/year:
   24,129,1986

TYPE OF TEST            : TC - Toxic concentration (other than lowest)
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 40 ppm/4H/52W-I
TOXIC EFFECTS :
   Tumorigenic - equivocal tumorigenic agent by RTECS criteria
   Brain and Coverings - tumors
REFERENCE :
   ANYAA9 Annals of the New York Academy of Sciences.  (New York Academy of
   Sciences, 2 E. 63rd St., New York, NY 10021)  V.1-    1877-
   Volume(issue)/page/year: 381,216,1982

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 3640 mg/kg/52W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Sense Organs and Special Senses (Ear) - effect, not otherwise specified
   Gastrointestinal - tumors
REFERENCE :
   DOWCC* Dow Chemical Company Reports.  (Dow Chemical USA, Health and
   Environment Research, Toxicology Research Lab., Midland, MI 48640)
   Volu

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 25 mg/kg
TOXIC EFFECTS :
   Sense Organs and Special Senses (Eye) - effect, not otherwise specified
   Behavioral - changes in motor activity (specific assay)
   Gastrointestinal - hypermotility, diarrhea
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   7,367,1965

TYPE OF TEST            : LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Mammal - dog
DOSE/DURATION           : 110 ppm/4H
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis without anesthesia
   (usually neuromuscular blockage)
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - coma
REFERENCE :
   JIHTAB Journal of Industrial Hygiene and Toxicology.  (Cambridge, MA)
   V.18-31, 1936-49.  For publisher information, see AEHLAU.
   Volume(issue)/page/year: 24,27,1942

TYPE OF TEST            : LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 425 ppm/4H
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   TXAPA9 Toxicology and Applied Pharmacology.  (Academic Press, Inc., 1 E.
   First St., Duluth, MN 55802) V.1-    1959-  Volume(issue)/page/year:
   29,81,1974

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rabbit
DOSE/DURATION           : 69 mg/kg
TOXIC EFFECTS :
   Peripheral Nerve and Sensation - flaccid paralysis with appropriate
   anesth

TYPE OF TEST            : LD50 - Lethal dose, 50 perce

TYPE OF TEST            : Mutation test systems - not otherwise specified
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 46500 ug/kg
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   47,363,1983

TYPE OF TEST            : Mutation in mammalian somatic cells
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 25 mg/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   5,497,1985

TYPE OF TEST            : Sex chromosome loss and nondisjunction
ROUTE OF EXPOSURE       : Inhalation
TEST SYSTEM             : Insect - Drosophila melanogaster
DOSE/DURATION           : 3 ppm
REFERENCE :
   MUREAV Mutation

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Rodent - hamster Embryo
DOSE/DURATION           : 200 mg/L
REFERENCE :
   JJIND8 JNCI, Journal of the National Cancer Institute.  (Washington, DC)
   V.61-79, 1978-87. For publisher information, see JNCIEQ.
   Volume(issue)/page/year: 62,1025,1979

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 mmol/L
REFERENCE :
   PMRSDJ Progress in Mutation Research.  (Elsevier Science Pub. Co., Inc., 52
   Vanderbilt Ave., New York, NY 10017)  V.1-    1981- Volume(issue)/page/year:
   5,371,1985

TYPE OF TEST            : DNA adduct
ROUTE OF EXPOSURE       : Oral
TEST SYSTEM             : Rodent - rat
DOSE/DURATION           : 46500 ug/kg
REFERENCE :
   CBINA8 Chemico-Biological Interactions.  (Elsevier Scientific Pub. Ireland
   Ltd., POB 85, Limerick, Ireland)  V.1-    1969-  Volume(issue)/page/year:
   47,363,1983

{hazard_com}

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 650 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
   Reproductive - Specific Developmental Abnormalities - cardiovascular
   (circulatory) system
REFERENCE :
   TJADAB Teratology, The International Journal of Abnormal Development. (Alan
   R. Liss, Inc., 41 E. 11th St., New York, NY 10003)  V.1-    1968-
   Volume(issue)/page/year: 17,50A,1978

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 650 mg/kg
SEX/DURATION            : female 6-15 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - female fertility index (e.g. # females pregnant
   per # sperm positive females; # females pregnant per # females mated)
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   DOWCC* Dow Chemical Company Reports.  (Dow Chemical USA, Health and
   Environment Research, Toxicology Research Lab., Midland, MI

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 644 mg/kg
SEX/DURATION            : male 2 week(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Paternal Effects - spermatogenesis (incl. genetic material,
   sperm morphology, motility, and count)
   Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
   TOXID9 Toxicologist.  (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway,
   Akron, OH 44311) V.1-    1981-  Volume(issue)/page/year: 14,87,1994

其他信息

下游产品:J型改性丙烯酸树脂乳液 --> 毒死蜱乳油 --> 橡胶浆 202BA --> 1,4-双(3-氨基丙基)哌嗪 --> 粘合剂 BA --> 硫代二丙酸双十二烷酯 --> 丁腈胶NBR --> N-羟甲基丙烯酰胺 --> 涂料印花粘合剂 --> N,N-二氰乙基苯胺 --> 2-氯-2-三氯乙基-
粮食熏蒸剂:1941～1942年由德国Degesch Gesellsch公司推荐丙烯腈用作粮食熏蒸剂。毒性：丙烯腈对人剧毒，毒性与氢氰酸相当。丙烯腈对昆虫的毒性很强，在防治多种贮粮害虫的主要熏蒸剂中，其毒性最强。丙烯腈单独使用或者同四氯化碳混合使用，对多种蔬菜、谷物和花卉种子的发芽没有什么影响，但对玉米种子有一定的伤害。丙烯腈和四氯化碳合剂可用于防治贮藏谷物中的绝大部分害虫。试验证明，丙烯腈和四氯化碳按体积1比1的比例配成混剂，可以用于防治贮藏马铃薯的马铃薯块茎蛾而不会损伤块茎。使用方法：因为丙烯腈和四氯化碳都是高沸点，常压熏蒸时，为了迅速蒸发，有人制备了一种简单的方法，用棉绳蕊穿过浅铁盘底。熏蒸开始时将液体熏蒸剂注入盘中，然后用风扇向棉蕊子吹风，直到蒸发完毕。
刺激数据:眼睛- 兔子 100 毫克中度; 皮肤- 兔子 50 毫克重度
方法一:其制备方法主要用丙烯氨氧化法，以丙烯、氨气和空气中的氧气为原料，在催化剂存在下进行反应，催化剂主要是含磷、钼、铋系的化合物，丙烯、氨和空气的摩尔比为1∶(1～1.2)∶(1.8～2.3)，反应温度为400～500℃，反应压力为常压，反应器为流化床。反应方程式：CH 2 ＝CH 2 —CH 3 +NH 3 +3/2O 2 →CH 2 ＝CH—CN+3H 2 O 该反应丙烯腈的单程收率60％～75％。
{Chemicalbook
毒性分级:高毒
易燃，发烟、有毒。有氧或露光下能自行聚合，与一定空气混合能引起爆炸。能溶于一般有机溶剂，微溶于水。有浓碱存在时能剧烈聚合。20℃时，7.35份溶于100份水或3.1份水溶于100份丙烯腈。能与大多数有机溶剂混溶。易燃，25℃时能与空气形成爆炸性混合物，爆炸极限3.05%-17.0%。中等毒，半数致死量（大鼠，经口）93mg/kg。
F:8
爆炸物危险特性:与
方法二:1.氰乙醇法环氧乙烷和氢氰酸在水和三甲胺的存在下反应得氰乙醇，然后以碳酸镁为催化剂，于200-280℃脱水制得丙烯腈,收率约75%。此法生产的丙烯腈纯度较高,但氢氰酸毒性大，成本也较高。2.乙炔法乙炔和氢氰酸在氯化亚铜-氯化钾-氯化钠稀盐酸溶液的催化作用下在80-90℃反应得丙烯腈此法生产过程简单，收率良好，以氢氰酸计可达97%。但副反应多，产物精制较难，毒性也大，且原料乙炔价格高于丙烯，在技术和经济上落后于丙烯氨氧化法。1960年以前,该法是世界各国生产丙烯腈的主要方法。3.丙稀氨氧化法以丙烯、氨、空气和水为原料，按其一定量配比进入沸腾床或固定床反应器，在以硅胶作载体的磷钼鉍系或锑铁系催化剂作用下，在400-500℃温度和常压下，生成丙烯腈。然后经中和塔用稀硫酸除去未反应的氨，再经吸收塔用水吸收丙烯腈等气体，形成水溶液，使该水溶液经萃取塔分离乙腈，在脱氢氰酸塔除去氢氰酸，经脱水、精馏而得丙烯腈产品，其单程收率可达75%，副产品有乙腈、氢氰酸和硫铵。此法是目前最有工业生产价值的生产方法。
用途三:丙烯腈是杀菌剂溴菌腈、霜霉威，杀虫剂毒死蜱和杀虫双、杀螟丹的中间体，还可以制备二氯菊酸甲酯用以生产拟除虫菊酯，也是杀虫剂虫满腈的中间体。
用途四:丙烯腈是合成纤维，合成橡胶和合成树脂的重要单体。由丙烯腈制得聚丙烯腈纤维即(腈纶)，其性能极似羊毛,因此也叫(合成羊毛)。丙烯腈与丁二烯共聚可制得丁腈橡胶，具有良好的耐油性，耐寒性，耐磨性，和电绝缘性能，并且在大多数化学溶剂，阳光和热作用下，性能比较稳定。丙烯腈与丁二烯，苯乙烯共聚制得ABS树脂，具有质轻,耐寒,抗冲击性能较好等优点。丙烯腈水解可制得丙烯酰胺和丙烯酸及其酯类。它们是重要的有机化工原料，丙烯腈还可电解加氢偶联制得己二腈，由己二腈加
外观
丙烯腈的主要用途和作用:（1）丙烯腈可用于制造丙烯腈纤维及碳纤维；用于生产L-谷氨酸钠(即味
蒸气压:86 mm Hg ( 20 °C)