A-61603 hydrate
CAS N/A MFCD16875412
化学结构图
SMILES:
化学属性
| Mol. Weight | 390.30 (anhydrous basis) |
|---|---|
| Mol. Formula | C14H19N3O3S·HBr · xH2O |
别名和识别编码
| Synonym | A-61603 hydrate N-[5-(4,5-dihydro-1H-imidazol-2yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulphonamide hydrobromide |
|---|---|
| MDL Number | MFCD16875412 |
| Chemical Name | A-61603 hydrate |
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分类
- Abbott, Adrenergics, Adrenergics - Agonists, Agonists, Approved Therapeutics/Drug Candidates, Biochemicals and Reagents,
- {SNA} A-AM, Abbott, Adrenergics, Adrenergics - Agonists, Agonists, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Fluorination Ready Pharma-Developed Compounds, GPCR Modulators, GPCR Proteins, Modulators and Antibodies, Membrane Protein Biology Tools, Neuroscience, Neurotransmission, Neurotransmitters, 生化试剂, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学, 蛋白质及衍生物
相关文献及参考
- Deighan, C., et al., Insights into the functional roles of α(1)-adrenoceptor subtypes in mouse carotid arteries using knockout mice Br. J. Pharmacol. 144 , 558-65, (2005)
- Copik, A.J., et al., Facilitatory interplay in {alpha}1A and {beta}2 adrenoceptor function reveals a non-Gq signaling mode: implications for diversification of intracellular signal transduction. Mol. Pharmacol. 75 , 713-728, (2009)
- Mills, K., et al., Characterization of the alpha1-adrenoceptor subtype mediating contractions of the pig internal anal sphincter. Br. J. Pharmacol. 155 , 110-117, (2008) 摘要
- O-Uchi, J., et al. , Interaction of alpha1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. Circ. Res. 102 , 1378-1388, (2008) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
