Raf

下级目录

Debio-0932 (CUDC305)

PF-04880594

Donafenib

CCT196969

CCT241161

GDC-0623

AS 703026

(LGX818) Encorafenib

(3R)-N-[3-[5-(2-Cyclopropylpyrimidin-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]-3-fluoropyrrolidine-1-sulfonamide

LY3009120

Kobe0065

Kobe-2602

E6201

NVP-BEP800

AZD-8330

3,4-difluoro-2-(2-fluoro-4-iodophenylaMino)-N-(2-hydroxyethoxy)-5-((3-oxoMorpholino)Methyl)benzaMide

AZ628

GDC-0879

N-(3-(5-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

3-[[3-Fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-4-methyl-7-pyrimidin-2-yloxychromen-2-one

GW5074

FTI-276 TRIFLUOROACETATE SALT

PD 0325901

Diazepinomicin

Dovitinib

L-779450

瑞格非尼

目录项下的产品

1061318-81-7 / MFCD161318817
Debio-0932 (CUDC305)

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1111636-35-1 / MFCD211636351
PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia. PF-04880594 stimulates production of the inflammatory cytokine interleukin 8 in HL-60 cells. Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901. The combination treatment with PF-04880594 and MEK inhibitors might greatly increase the safety and therapeutic index of RAF inhibitors for the treatment of melanoma and other cancers.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1130115-44-4 / MFCD230115444
4-(4-(3-(4-Chloro-3-(Trifluoromethyl)Phenyl)Ureido)Phenoxy)-N-(Methyl-D3)Picolinamide
4-(4-(3-(4-氯-3-(三氟甲基)苯基)脲基)苯氧基)-N-(甲基-d3)吡啶-2-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1163719-56-9 / MFCD263719569
CCT196969

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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1163719-91-2 / MFCD263719912
CCT241161 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. CCT241161 blocked growth of BRAF-mutant and NRAS-mutant melanoma cells, inhibiting MEKÂ–ERK, in vitro and in vivo. CCT241161 also prevented growth of xenografts derived from patient tumours with acquired or intrinsic resistance to BRAF and MEK inhibitors. BRAF and MEK inhibitors are effective in BRAF mutant melanoma, but most patients eventually relapse with acquired resistance, and others present intrinsic resistance to these drugs.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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1168091-68-6 / MFCD268091686
5-((2-Fluoro-4-Iodophenyl)Amino)-N-(2-Hydroxyethoxy)Imidazo[1,5-A]Pyridine-6-Carboxamide
5-((2-氟-4-碘苯基)氨基)-N-(2-羟基乙氧基)咪唑并[1,5-a]吡啶-6-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

1236699-92-5 / MFCD336699925
Pimasertib
N-[(2S)-2,3-二羟基丙基]-3-[(2-氟-4-碘苯基)氨基]-4-吡啶甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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1269440-17-6 / MFCD369440176
(S)-Methyl [1-[[4-[3-[5-chloro-2-fluoro-3-(methylsulfonamido)phenyl]-1-isopropyl-1H-pyrazol-4-yl]pyrimidin-2-yl]amino]propan-2-yl]carbamate
(S)-[1-[[4-[3-[5-氯-2-氟-3-(甲基磺酰胺基)苯基]-1-异丙基-1H-吡唑-4-基]嘧啶-2-基]氨基]丙-2-基]氨基甲酸甲酯

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

1393466-87-9 / MFCD493466879
PLX8394 is an orally bioavailable inhibitor of serine/threonine-protein kinase B-raf (BRAF) protein with potential antineoplastic activity. PLX8394 appears to selectively bind to and inhibit the activity of both wild-type and mutated forms of BRAF, which may subsequently inhibit the proliferation of tumor cells which express mutated forms of BRAF. PLX8394 appears to be effective against tumors that express multiple mutated forms of the kinase and may be an effective therapeutic agent for tumors that are resistant to other BRAF inhibitor therapies that are specific for the BRAF V600E mutant.
PLX8394游离态

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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中华人民共和国

1454682-72-4 / MFCD554682724
1-(3,3-Dimethylbutyl)-3-(2-Fluoro-4-Methyl-5-(7-Methyl-2-(Methylamino)Pyrido[2,3-D]Pyrimidin-6-Yl)Phenyl)Urea
1-(3,3-二甲基丁基)-3-(2-氟-4-甲基-5-(7-甲基-2-(甲胺基)吡啶并[2,3-d]嘧啶-6-基)苯基)脲

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

436133-68-5 / MFCD36133685
Kobe0065
N-(3-氯-4-甲基苯基)-2-[2,6-二硝基-4-(三氟甲基)苯基]肼基硫代甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

454453-49-7 / MFCD54453497
2-(2,6-Dinitro-4-(trifluoromethyl)phenyl)-N-(4-fluorophenyl)hydrazine-1-carbothioamide
2-[2,6-二硝基-4-(三氟甲基)苯基]-N-(4-氟苯基)肼基硫代甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国

603987-35-5 / MFCD03987355
E6201 is a synthetic, fungal metabolite analogue inhibitor of mitogen-activated protein kinase kinase 1 (MEK-1) and mitogen-activated protein kinase kinase kinase 1 (MEKK-1) with potential antipsoriatic and antineoplastic activities. MEK-1/MEKK-1 inhibitor E6201 specifically binds to and inhibits the activities of MEK-1 and MEKK-1, which may result in the inhibition of tumor cell proliferation. MEK-1 and MEKK-1 are key components in the RAS/RAF/MEK/MAPK signaling pathway, which regulates cell proliferation and is frequently activated in human cancers.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

847559-80-2 / MFCD47559802
NVP-BEP800
NVP-BEP800;2-AMINO-4-(2,4-DICHLORO-5-(2-(PYRROLIDIN-1-YL)ETHOXY)PHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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869357-68-6 / MFCD69357686
AZD8330, also known as ARRY704 and ARRY424704, is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor AZD8330 specifically inhibits mitogen-activated protein kinase kinase 1 (MEK or MAP/ERK kinase1), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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874101-00-5 / MFCD74101005
3,4-Difluoro-2-((2-Fluoro-4-Iodophenyl)Amino)-N-(2-Hydroxyethoxy)-5-((3-Oxo-1,2-Oxazinan-2-Yl)Methyl)Benzamide
3,4-二氟-2-((2-氟-4-碘苯基)氨基)-N-(2-羟基乙氧基)-5-((3-氧代-1,2-噁嗪烷-2-基)甲基)苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

878739-06-1 / MFCD78739061
3-(2-Cyanopropan-2-yl)-N-(4-methyl-3-((3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)amino)phenyl)benzamide
3-(2-氰基丙烷-2-基)-N-(4-甲基-3-((3-甲基-4-氧代-3,4-二氢喹唑啉-6-基)氨基)苯基)苯甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

905281-76-7 / MFCD005281767
(E)-5-(1-(2-hydroxyethyl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl)-2,3-dihydroinden-1-one oxime
2,3-二氢-5-[1-(2-羟基乙基)-3-(4-吡啶基)-1H-吡唑-4-基]-1H-茚-1-酮肟

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

918505-84-7 / MFCD018505847
N-(3-(5-Chloro-1H-Pyrrolo[2,3-B]Pyridine-3-Carbonyl)-2,4-Difluorophenyl)Propane-1-Sulfonamide
N-(3-(5-氯-1H-吡咯并[2,3-b]吡啶-3-羰基)-2,4-二氟苯基)丙烷-1-磺酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
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946128-88-7 / MFCD046128887
RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity. Raf/MEK dual kinase Inhibitor RO5126766 specifically inhibits the kinase activities of Raf and MEK, resulting in the inhibition of of target gene transcription that promotes malignant transformation of cells. Both Raf and MEK are serine/threonine-specific kinases that respond to extracellular stimuli, such as mitogens, and are involved in the regulation of cellular processes, such as gene expression, mitosis, differentiation, and apoptosis.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

220904-83-6 / MFCD03453076
3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one
3-(3,5-二溴-4-羟基苯亚甲基)-5-碘-1,3-二氢吲哚-2-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
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170006-72-1 / MFCD06409253
FTI-276 is a potent and selective farnesyltransferase inhibitor, which is also a tetrapeptide mimetic of the carboxyl terminus of K-Ras4B. FTI-276 blocked the growth in nude mice of a human lung carcinoma that expresses the two most prevalent genetic alterations in human cancers (K-Ras oncogenic mutation and deletion in the tumor suppressor gene p53). In contrast, FTI-276 did not inhibit tumor growth of a human lung carcinoma that harbors no Ras mutations. Furthermore, FTI-276 inhibited oncogenic signaling and tumor growth of NIH 3T3 cells transformed with the ras but not the raf oncogene.

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
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391210-10-9 / MFCD08435926
PD0325901
MEK1/2抑制剂III

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

733035-26-2 / MFCD09955031
Diazepinomicin, also known as TLN-4601, is a small-molecule inhibitor of the RAS/RAF/MAPK signaling pathway with potential antineoplastic activity. Diazepinomicin binds to and inhibits Ras kinase, thereby preventing the phosphorylation and activation of proteins downstream of the Ras signal transduction pathway, including serine/threonine kinase RAF (BRAF) and extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK-2). This agent also selectively binds to the peripheral benzodiazepine receptor (PBR), a receptor highly expressed in certain tumor cell types cells, inducing cell cycle arrest and apoptosis in PBR-expressing cells. Diazepinomicin can cross the blood-brain barrier (BBB).

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405169-16-6 / MFCD10565680
4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one
4-氨基-5-氟-3-[5-(4-甲基哌嗪-1-基)-1H-苯并咪唑-2-基]喹啉-2(1H)-酮

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
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303727-31-3 / MFCD12828750
2-Chloro-5-(2-Phenyl-4-(Pyridin-4-Yl)-1H-Imidazol-5-Yl)Phenol
2-氯-5-(2-苯基-5-(吡啶-4-基)-1H-咪唑-5-基)苯酚

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

755037-03-7 / MFCD16038047
4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-3-fluorophenoxy]-N-methyl-2-pyridinecarboxamide
4-[4-[[[4-氯-3-(三氟甲基)苯基]氨基甲酰]氨基]-3-氟苯氧基]-N-甲基吡啶-2-甲酰胺

原料 0 ^资源 0.0^询 0.0^%成交 ^交易量
试剂

中华人民共和国
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