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Androgen Receptor

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Apoptone

2,2,5,7,8-Pentamethyl-6-chromanol

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183387-50-0

183387-50-0 / MFCD83387500
Apoptone, also known as HE3235, is an orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2.

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950-99-2

950-99-2 / MFCD00210347
2,2,5,7,8-Pentamethyl-6-chromanol
2,2,5,7,8-五甲基-6-苯并甲醇

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