Topoisomerase

下级目录

Becatecarin

AEZS-112

Edotecarin

Karenitecin

KU59403

Indotecan

Indimitecan

GPX100

Dactinomycin

Betulinic acid

ELLIPTICINE

(S)-(+)-Camptothecin

10-HYDROXYCAMPTOTHECIN

Etoposide Phosphate

5,12-Naphthacenedione,7,8,9,10-tetrahydro-10-((tetrahydro-4-amino-6-methyl-2H-pyran-2-yl)oxy)-8-glycoloyl-1-methoxy-6,8,11-trihydroxy-

Elsamitrucin

2,6-Piperazinedione, 4,4'-propylenedi-, (+)-

6H-Pyrido(4,3-b)carbazolium,9-hydroxy-2,5,11-trimethyl-, acetate

依托泊甙

Annamycin

β-Lapachone

Phenoxodiol

Gimatecan

(S)-3-(1H-BENZO[D]IMIDAZOL-2-YL)-6-CHLORO-4-(QUINUCLIDIN-3-YLAMINO)-3,4-DIHYDROQUINOLIN-2(1H)-ONE DIHYDROCHLORIDE

目录项下的产品

119673-08-4 / MFCD19673084
Becatecarin

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1214741-69-1 / MFCD314741691
AEZS-112, also known as ZEN012, is an orally active small mol. anti-cancer drug which inhibits the polymn. of tubulin at low micromolar concns. AEZS 112 dose-dependently increased non-vital hypodiploid cells and the cytotoxic effect was least pronounced in G2 phase of the cell cycle, indicating cell death during mitosis, as detd. by FACS anal. AEZS 112 showed anti-tumor activity in human ovarian and endometrial cancer cell lines at low micromolar concns., which could not be abrogated by caspase inhibition and is therefore a good candidate for in vivo studies in these tumors.

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174402-32-5 / MFCD74402325
Edotecarin is a synthetic indolocarbazole with antineoplastic activity. Edotecarin inhibits the enzyme topoisomerase I through stabilization of the DNA-enzyme complex and enhanced single-strand DNA cleavage, resulting in inhibition of DNA replication and decreased tumor cell proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

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203923-89-1 / MFCD03923891
Karenitecin, also known as Cositecan, is a synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Karenitecin stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, karenitecin exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins.
(4S)-4-乙基-4-羟基-11-(2-三甲基硅基)乙基)-1H-吡喃并[3',4':6,7]氮茚并[1,2-B]喹啉-3,14(4H,12H)-二酮

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845932-30-1 / MFCD45932301
KU59403

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915303-09-2 / MFCD015303092
Indotecan, also known as LMP400, is a novel selective and potent topoisomerase I inhibitor with potential anticancer activitity. Indotecan is currently in Phase I trials.

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915360-05-3 / MFCD015360053
Indimitecan, also known as LMP776, is a novel topoisomerase I inhibitor.

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952648-77-0 / MFCD052648770
GPX-100 is a n analogue of the anthracycline antineoplastic antibiotic doxorubicin. GPX-100 intercalates DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. GPX-100 was designed to be a non-cardiotoxic anthracycline antibiotic. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

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50-76-0 / MFCD00005033
Dactinomycin
放线菌素D

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472-15-1 / MFCD00009619
Betulinic Acid
桦木酸

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中华人民共和国
√

519-23-3 / MFCD00010524
5,11-Dimethyl-6H-Pyrido[4,3-B]Carbazole
5,11-二甲基-6H-吡啶并[4,3-b]咔唑

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河北省
中华人民共和国
上海市

7689-03-4 / MFCD00081076
(+)-Camptothecin
喜树碱

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深圳市
√
成都市
山东省
安徽省
中华人民共和国
武汉市
上海市
天津市
北京市

19685-09-7 / MFCD00189425
(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
(4S)-4-乙基-4,9-二羟基-1H-吡喃并[3',4':6,7]吲嗪并[1,2-b]喹啉-3,14-(4H,12H)-二酮

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中华人民共和国
√

117091-64-2 / MFCD00270859
Etoposide phosphate is a phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent.

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63521-85-7 / MFCD00866270
Esorubicin is a synthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin with potential antineoplastic activity. Esorubicin intercalates into DNA and inhibits topoisomerase II, thereby inhibiting DNA replication and ultimately, interfering with RNA and protein synthesis. This agent exhibits less cardiotoxicity than the parent antibiotic doxorubicin, but may cause more severe myelosupression compared to other compounds within the anthracycline class. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

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97068-30-9 / MFCD00866439
Elsamitrucin is a heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21. Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

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24584-09-6 / MFCD00866449
Dexrazoxane
(S)-4,4’-(丙烷-1,2-二基)双(哌嗪-2,6-二酮)

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中华人民共和国
√

58337-35-2 / MFCD00866541
Celiptium, also known as elliptinium acetate, a topoisomerase II inhibitor, is the acetate salt of elliptinium, a derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties. As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis.

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33419-42-0 / MFCD00869325
(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
4'-去甲基表鬼臼毒素-beta-D-乙叉吡喃葡萄糖甙

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中华人民共和国
北京市
√

92689-49-1 / MFCD00914599
Annamycin is a semi-synthetic doxorubicin analogue annamycin with antineoplastic activity. Annamycin intercalates into DNA and inhibits topoisomerase II, resulting in the inhibition of DNA replication and repair and RNA and protein synthesis. This agent circumvents multidrug-resistance (MDR) transporters, including P-glycoprotein (P-gp).

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4707-32-8 / MFCD01712233
3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
3,4-二氢-2,2-二甲基-2H-萘并[1,2-b]吡喃-5,6-二酮

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中华人民共和国
√

81267-65-4 / MFCD06636630
Idronoxil, also known as Phenoxodiol, is a synthetic flavonoid derivative. Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death.

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292618-32-7 / MFCD06795143
Gimatecan

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405168-58-3 / MFCD12031512
CHIR-124 is a quinolone-based small molecule Chk1 inhibitor, that is structurally unrelated to other known inhibitors of Chk1. It potently and selectively inhibits Chk1 in vitro (IC(50) = 0.0003 micromol/L). CHIR-124 interacts synergistically with topoisomerase poisons (e.g., camptothecin or SN-38) in causing growth inhibition in several p53-mutant solid tumor cell lines as determined by isobologram or response surface analysis. CHIR-124 is a novel and potent Chk1 inhibitor with promising antitumor activities when used in combination with topoisomerase I poisons.

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