2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid 2-氰基-3-(1-苯基-1H-吲哚-3-基)-2-丙烯酸
CAS 56396-35-1 MFCD19443867
化学结构图
SMILES: N#C/C(=C\C1=CN(C2C=CC=CC1=2)C1C=CC=CC=1)/C(O)=O
化学属性
| Mol. Weight | 288.30 |
|---|---|
| Mol. Formula | C18H12N2O2 |
别名和识别编码
| Synonym | 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid PF-1005023 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid PF-1005023 |
|---|---|
| MDL Number | MFCD19443867 |
| CAS Number | 56396-35-1 |
| Chemical Name | 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid |
| Chemical Name Translation | 2-氰基-3-(1-苯基-1H-吲哚-3-基)-2-丙烯酸 |
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分类
- {SNA} Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Mitochondrial Proteins, Antibodies, and Transport Inhibitors, Mitochondrial Transport Inhibitors, Pfizer Compounds
- Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Mitochondrial Proteins, Antibodies, and Transport Inhibitors, Mitochondrial Transport Inhibitors, Pfizer Compounds
- {SNA} Apoptosis and Cell Cycle, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Mitochondrial Proteins, Antibodies, and Transport Inhibitors, Mitochondrial Transport Inhibitors, Pfizer Compounds, U, 生物活性小分子,
相关文献及参考
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- [3]. Hinoi E, et al. A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol Pharmacol. 2006 Sep;70(3):925-35. Epub 2006 Jun 9.
- [4]. Patterson JN, et al. Mitochondrial metabolism of pyruvate is essential for regulating glucose-stimulated secretion. J Biol Chem. 2014 May 9;289(19):13335-46.
- [5]. Zhong Y, et al. Application of mitochondrial pyruvate carrier blocker UK5099 creates metabolic reprogram and greater stem-like properties in LnCap prostate cancer cells in vitro. Oncotarget. 2015 Nov 10;6(35):37758-69.
- Butcher, L., et al., Metabolism of pyruvate by the early human embryo. Biol. Reprod. 58 , 1054-1056, (1998)
- Nakamichi, N., et al., Protection by exogenous pyruvate thro
安全信息
- H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
