4-((((2R,3S,4R,5R)-5-(6-Amino-8-((3,4-Dichlorobenzyl)Amino)-9H-Purin-9-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methoxy)Methyl)Benzonitrile 4-((((2R,3S,4R,5R)-5-(6-氨基-8-(3,4-二氯苄基)氨基)-9H-嘌呤-9-基)-3,4-二羟四氢呋喃-2-基)甲氧基)甲基)苯甲腈
CAS 1134156-31-2 MFCD18086892
化学结构图
SMILES: NC1=NC=NC2=C1N=C(NCC1C=C(Cl)C(Cl)=CC=1)N2[C@@H]1O[C@H](COCC2C=CC(=CC=2)C#N)[C@@H](O)[C@H]1O |&1:20,22,34,36|
化学属性
| Mol. Weight | 556.40 |
|---|---|
| Mol. Formula | C25H23Cl2N7O4 |
别名和识别编码
| Synonym | 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine VER-155008 |
|---|---|
| Chemical Name | 4-((((2R,3S,4R,5R)-5-(6-Amino-8-((3,4-Dichlorobenzyl)Amino)-9H-Purin-9-yl)-3,4-Dihydroxytetrahydrofuran-2-yl)Methoxy)Methyl)Benzonitrile |
| MDL Number | MFCD18086892 |
| Chemical Name Translation | 4-((((2R,3S,4R,5R)-5-(6-氨基-8-(3,4-二氯苄基)氨基)-9H-嘌呤-9-基)-3,4-二羟四氢呋喃-2-基)甲氧基)甲基)苯甲腈 |
| PubChem Substance ID | 329825279 |
| CAS Number | 1134156-31-2 |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index, Heat Shock and Related Proteins, V, 一氧化氮和细胞应激, 伴侣蛋白和热休克蛋白, 生物活性小分子, 细胞信号转导和神经科学, 细胞应激, 细胞生物学
- {SNA} Cell Biology, Cell Signaling and Neuroscience, Cell Stress, Cha
相关文献及参考
- [2]. Yang X, et al. Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2018 Jan 30;9:48.
- [3]. Kita K, et al. Heat shock protein 70 inhibitors suppress androgen receptor expression in LNCaP95 prostate cancer cells. Cancer Sci. 2017 Sep;108(9):1820-1827.
- [1]. Massey AJ, et al. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45.
- [1]. Massey AJ, et al. A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells. Cancer Chemother Pharmacol. 2010 Aug;66(3):535-45.
- [2]. Yang X, et al. Heat Shock Cognate 70 Inhibitor, VER-155008, Reduces Memory Deficits and Axonal Degeneration in a Mouse Model of Alzheimer's Disease. Front Pharmacol. 2018 Jan 30;9:48.
- [3].
