PD166866 1-(2-氨基-6-(3,5-二甲氧基苯基)吡啶并[2,3-d]嘧啶-7-基)-3-(叔丁基)脲
CAS 192705-79-6 MFCD12922514
化学结构图
SMILES: COc1cc(OC)cc(-c2cc3cnc(N)nc3nc2NC(=O)NC(C)(C)C)c1
化学属性
| Mol. Weight | 396.44296 |
|---|---|
| Mol. Formula | C20H24N6O3 |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Synonym | 1-[2-Amino-6-(3,5-dimethoxyphenyl)-pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butyl urea PD-166866 PD166866; PD166866; PD 166866. |
|---|---|
| Chemical Name | PD166866 |
| MDL Number | MFCD12922514 |
| PubChem Substance ID | 329823706 |
| Chemical Name Translation | 1-(2-氨基-6-(3,5-二甲氧基苯基)吡啶并[2,3-d]嘧啶-7-基)-3-(叔丁基)脲 |
| Formula | C20H24N6O3 |
| IUPAC Name | 1-(2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea. |
| InChIKey | NHJSWORVNIOXIT-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27) |
| Canonical SMILES | O=C(NC(C)(C)C)NC1=NC2=NC(N)=NC=C2C=C1C3=CC(OC)=CC(OC)=C3 |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, P, Pfizer Compounds, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, Tyrosine Kinase (TK)
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, Kinase/Phosphatase Biology, P-PH, Pfizer Compounds, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors, Tyrosine Kinase (TK), 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- PD166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4. PD166866 has clear antiproliferative effects.
安全信息
GHS Symbol
- H302 Harmful if swallowed 吞食有害
- R22 Harmful if swallowed 吞咽有害
