6,7,8,9,10,11-Hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl sulfamate 6-氧代-6,7,8,9,10,11-六氢环庚并[c]苯并吡喃-3-基氨基磺酸酯
CAS 288628-05-7 MFCD12912443
化学结构图
SMILES: NS(=O)(=O)OC1C=CC2C3CCCCCC=3C(=O)OC=2C=1
化学属性
| Mol. Formula | C14H15NO5S |
|---|---|
| Mol. Weight | 309.34 |
别名和识别编码
| Chemical Name | 6,7,8,9,10,11-Hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl sulfamate |
|---|---|
| Synonym | 667 Coumate 667 Coumate BN 83495 BN 83495 |
| MDL Number | MFCD12912443 |
| CAS Number | 288628-05-7 |
| PubChem Substance ID | 329824496 |
| Chemical Name Translation | 6-氧代-6,7,8,9,10,11-六氢环庚并[c]苯并吡喃-3-基氨基磺酸酯 |
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分类
- Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, Hormones, Other Steroid Products, Steroid Hormones
- {SNA} Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Hormones, Other Steroid Products, S, Steroid Hormones,
相关文献及参考
- Woo, L.W., et al., Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography. Mol. Cancer Ther. 7 , 2535-2544, (2008)
- Stanway, S.J., et al., Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. Clin. Cancer Res. 12 , 1585-1592, (2006)
- Purohit, A., et al., In vivo inhibition of estrone sulfatase activity and growth of nitrosomethylurea-induced mammary tumors by 667 Coumate. Cancer Res. 60 , 3394-3396, (2000)
