4-(4-Fluorophenyl)-2-(4-Nitrophenyl)-5-(4-Pyridyl)-1H-Imidazole 4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶
CAS 152121-53-4 MFCD12405019
化学结构图
SMILES: O=[N+]([O-])c1ccc(-c2nc(-c3ccncc3)c(-c3ccc(F)cc3)[nH]2)cc1
化学属性
| Mol. Formula | C20H13FN4O2 |
|---|---|
| Mol. Weight | 360.35 |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 4-(4-Fluorophenyl)-2-(4-Nitrophenyl)-5-(4-Pyridyl)-1H-Imidazole |
|---|---|
| CAS Number | 152121-53-4 |
| Synonym | 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole 4-[4-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-5-yl]pyridine 4-[5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl]pyridine PD 169316 PD-169316; PD 169316; PD169316. |
| PubChem Substance ID | 354335509 |
| MDL Number | MFCD12405019 |
| Chemical Name Translation | 4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶 |
| Reaxys-RN | 7660816 |
| Formula | C20H13FN4O2 |
| IUPAC Name | 4-(5-(4-fluorophenyl)-2-(4-nitrophenyl)-1H-imidazol-4-yl)pyridine |
| InChIKey | BGIYKDUASORTBB-UHFFFAOYSA-N |
| InChI | InChI=1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24) |
| Canonical SMILES | O=[N+](C1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C(F)C=C4)N2)C=C1)[O-] |
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分类
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, GlaxoSmithKline, Kinase/Phosphatase Biology, P, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, p38 Mitogen-Activated protein kinase (p38MAPK)
- Approved Therapeutics/Drug Candidates, Bioacti
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, GlaxoSmithKline, Kinase/Phosphatase Biology, P-PH, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, p38 Mitogen-Activated protein kinase (p38MAPK), 生物活性小分子, 细胞信号转导和神经科学,
产品应用
- PD-169316 is a selective inhibitor of p38 MAPK. It inhibits p38 MAPK with an IC50 of 89 nM. PD169316, inhibits transforming growth factor beta-induced Smad signaling in human ovarian cancer cells.
相关文献及参考
- Fu, Y. et al.: Bioche,. Biophys. Res. Comm., 310, 391 (2003); Krishnamoorthy, M. et al.: J. Biochem., 145, 177 (2009); Schwertz, H. et al.: Proteomics, 7, 24 (2007);
- Walshe, T., et al., Inhibition Of VEGF Or TGF-β Signaling Activates Endothelium And Increases Leukocyte Rolling Arterioscler. Thromb. Vasc. Biol. 29 , 1185-1192, (2009) 摘要
- Walshe, T.E., et al., Inhibition Of VEGF Or TGF-{beta} Signaling Activates Endothelium And Increases Leukocyte Rolling. Arterioscler. Thromb. Vasc. Biol. 29 , 1185-92, (2009) 摘要
- Gallagher, T.F., et al. Bioorg. Med. Chem. 5 , 49, (1997)
安全信息
GHS Symbol
- H315 Causes skin irritation 会刺激皮肤
- H318 Causes serious eye damage 严重伤害眼睛
- H301 Toxic if swallowed 吞食有毒
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- P301+P310
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S39 Wear eye/face protection 戴眼睛/面孔保护装置；
- R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性
- R22 Harmful if swallowed 吞咽有害
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
