6-((4-((3-(Methylsulfonyl)Benzyl)Amino)-5-(Trifluoromethyl)Pyrimidin-2-Yl)Amino)-3,4-Dihydroquinolin-2(1H)-One 6-((4-((3-(甲磺酰基)苄基)氨基)-5-(三氟甲基)嘧啶-2-基)氨基)-3,4-二氢喹啉-2(1H)-酮

CAS 869288-64-2 MFCD11519967

化学结构图

869288-64-2
SMILES: CS(=O)(=O)c1cccc(CNc2nc(Nc3ccc4c(c3)CCC(=O)N4)ncc2C(F)(F)F)c1

化学属性

Mol. FormulaC22H20F3N5O3S
Mol. Weight491.48611
Appearance White solid powder
SolubilitySoluble in DMSO, not in water

别名和识别编码

Chemical Name6-((4-((3-(Methylsulfonyl)Benzyl)Amino)-5-(Trifluoromethyl)Pyrimidin-2-Yl)Amino)-3,4-Dihydroquinolin-2(1H)-One
CAS Number869288-64-2
Synonym 3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone 6-[(4-((3-(Methanesulfonyl)benzyl)amino)-5-trifluoromethylpyrimidin-2-yl)amino]- 6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one 6-[4-(3-Methanesulfonyl-benzylamino)-5-trifluoromethyl-pyrimidin-2-ylamino]-3,4-dihydro-1H-quinolin-2-one PF-228 PF-228 PF573228; PF 573228; PF-573228; PF573,228; PF 573,228; PF-573,228.
MDL NumberMFCD11519967
Chemical Name Translation6-((4-((3-(甲磺酰基)苄基)氨基)-5-(三氟甲基)嘧啶-2-基)氨基)-3,4-二氢喹啉-2(1H)-酮
PubChem Substance ID329823709
FormulaC22H20F3N5O3S
IUPAC Name3,4-Dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
InChIKeyHESLKTSGTIBHJU-UHFFFAOYSA-N
InChIInChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30)
Canonical SMILESO=C1NC2=C(C=C(NC3=NC=C(C(F)(F)F)C(NCC4=CC=CC(S(=O)(C)=O)=C4)=N3)C=C2)CC1
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Focal Adhesion Kinase (FAK), Kinase/Phosphatase Biology, Non-Receptor Tyrosine Kinase Biology, Non-Receptor Tyrosine Kinase Inhibitors, P-PH, Pfizer Compounds, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Focal Adhesion Kinase (FAK), Kinase/Phosphatase Biology, Non-Receptor Tyrosine Kinase Biology, Non-Receptor Tyrosine Kinase Inhibitors, P, Pfizer Compounds

产品应用

  • PF-573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50= 4 nM). Displays 50 - 250-fold selectivity for FAK over other protein kinases. PF573228 was recognized to affect cell adhesion and migration in many types of cells.

相关文献及参考

  • Slack-Davis, J.K. et al.: J. Biol. Chem., 282, 14845 (2007); Hiscox, S. et al.: Breast Cancer Res. Treat., 125, 659 (2011);
  • Slack-Davis, J.K., et al., Cellular characterization of a novel focal adhesion kinase inhibitor. J. Biol. Chem. Mar 28th ed.,, (2007)

安全信息

GHS Symbol
Precautionary statements
  • P301+P310
  • P305+P351+P338
Signal word Danger
Hazard statements
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301 Toxic if swallowed 吞食有毒
WGK Germany3
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
  • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Hazard Codes T
Risk Statements
  • R25 Toxic if swallowed 吞咽有毒
  • R36 Irritating to eyes 刺激眼睛
Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Kinase/Phosphatase Biology - Cell Signaling and Neuroscience
  5. Non-Receptor Tyrosine Kinase Biology - Kinase/Phosphatase Biology
  6. Non-Receptor Tyrosine Kinase Inhibitors - Non-Receptor Tyrosine Kinase Biology
  7. Focal Adhesion Kinase (FAK) - Non-Receptor Tyrosine Kinase Inhibitors
  1. Medical Research Areas
  2. Angiogenesis
  3. FAK
  1. Medical Research Areas
  2. Cytosketetal Signaling
  3. FAK

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