2-((3,5-Difluoro-4-Hydroxyphenyl)Amino)-8-Isopentyl-5,7-Dimethyl-7,8-Dihydropteridin-6(5H)-One 2-((3,5-二氟-4-羟基苯基)氨基)-8-异戊基-5,7-二甲基-7,8-二氢蝶啶-6(5H)-酮
CAS 501437-28-1 MFCD11223662
化学结构图
SMILES: CC(C)CCN1c2nc(Nc3cc(F)c(O)c(F)c3)ncc2N(C)C(=O)C1C
化学属性
| Mol. Formula | C19H23F2N5O2 |
|---|---|
| Mol. Weight | 391.41 |
| Appearance | Pale orange to brown solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | 2-((3,5-Difluoro-4-Hydroxyphenyl)Amino)-8-Isopentyl-5,7-Dimethyl-7,8-Dihydropteridin-6(5H)-One |
|---|---|
| Formula | C19H23F2N5O2 |
| Synonym | BID1870; BI D1870; BI-D1870. |
| IUPAC Name | 2-((3,5-difluoro-4-hydroxyphenyl)amino)-8-isopentyl-5,7-dimethyl-7,8-dihydropteridin-6(5H)-one. |
| InChIKey | DTEKTGDVSARYDS-UHFFFAOYSA-N |
| InChI | InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24) |
| Canonical SMILES | O=C1N(C)C2=CN=C(NC3=CC(F)=C(O)C(F)=C3)N=C2N(CCC(C)C)C1C |
| Chemical Name Translation | 2-((3,5-二氟-4-羟基苯基)氨基)-8-异戊基-5,7-二甲基-7,8-二氢蝶啶-6(5H)-酮 |
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产品应用
- BI-D1870 is a potent and specific RSK inhibitor (the p90 ribosomal S6 kinase), which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10–30 nM. BI-D1870 exhibited a dose-responsive antiproliferative effect on OSCC cells with relative sparing of normal human oral keratinocytes. The compound inhibited the downstream RSK target YB-1 and caused apoptosis. In addition, BI-D1870 also induced G2/M arrest by modulating the expression of p21 and other cell cycle regulators. BI-D1870 may be of useful in oral squamous cell carcinoma therapy.
