Tacrolimus For System Suitability 他克莫司一水合物
CAS 109581-93-3 MFCD11045918
化学结构图
SMILES: O.CC1C[C@H](C)C[C@H](OC)[C@H]2O[C@](O)([C@H](C)C[C@@H]2OC)C(=O)C(=O)N2CCCC[C@H]2C(=O)O[C@@H]([C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)C=1)/C(/C)=C/[C@H]1C[C@@H](OC)[C@H](O)CC1 |c:46|
化学属性
| Mol. Formula | C44H71NO13 |
|---|---|
| Mol. Weight | 822 |
| Melting Point | 125-129 |
别名和识别编码
| Chemical Name | Tacrolimus For System Suitability |
|---|---|
| Synonym | FK-506 monohydrate Tacrolimus FK-506 monohydrate Tacrolimus |
| CAS Number | 109581-93-3 |
| PubChem Substance ID | 160871186 |
| MDL Number | MFCD11045918 |
| Reaxys-RN | 6265275 |
| Merck Number | 9025 |
| Chemical Name Translation | 他克莫司一水合物 |
| Beilstein Registry Number | 6265275 |
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信息真实价格透明
资金保障
专业采购外包团队在线服务
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分类
- {SN
- {SNA} A to C, Bioactive Small Molecules, Biochemicals and Reagents, Calcineurin, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, F,
- {SNA} A to C, Bioactive Small Molecule Alphabetical Index, Calcineurin, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, F, Kinase/Phosphatase Biology, Protein Phosphatase 2B (Calcineurin/PP2B), Serine/Threonine Kinase Biology, Serine/Threonine Phosphatase Inhibitors,
- {SNA} Analytical Standards, Pharmacopeia & Metrological Institutes Standards, USP Standards, USP Standards S - T, 分析/色谱
相关文献及参考
- [2]. Okada Y, et al. Tacrolimus ameliorates dextran sulfate sodium-induced colitis in mice: implication of interferon-γ and interleukin-1β suppression. Biol Pharm Bull. 2011;34(12):1823-7.
- [3]. Vogel KR, et al. mTOR inhibitors rescue premature lethality and attenuate dysregulation of GABAergic/glutamatergic transcription in murine succinate semialdehyde dehydrogenase deficiency (SSADHD), a disorder of GABA metabolism. J Inherit Metab Dis. 2016 Nov;39(6):877-886.
- [4]. Zhu H, et al. Tacrolimus promotes hepatocellular carcinoma and enhances CXCR4/SDF 1α expression in vivo. Mol Med Rep. 2014 Aug;10(2):585-92.
- Bieri, M., et al., Biosynthesis And Expression Of VE-cadherin Is Regulated By The PI3K/mTOR Signaling Pathway. Mol. Immunol. 46 , 866-72, (2009) 摘要
- Gold, B.G
- Gold, B.G., Neuroimmunophilin ligands: evaluation of their therapeutic potential for the treatment of neurological disorders. Expert Opin. Investig. Drugs 9 , 2331-2342, (2000)
安全信息
GHS Symbol
- H301 Toxic if swallowed 吞食有毒
- P301+P310+P330
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- P405 Store locked up. 上锁保管。
- P301+P310
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P330 Rinse mouth. 漱口
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- R25 Toxic if swallowed 吞咽有毒
