6-(2-(Tert-Butyl)-5-(6-Methylpyridin-2-Yl)-1H-Imidazol-4-Yl)Quinoxaline 6-(2-(叔丁基)-5-(6-甲基吡啶-2-基)-1H-咪唑-4-基)喹喔啉

CAS 356559-20-1 MFCD11045307

化学结构图

356559-20-1
SMILES: CC1=CC=CC(=N1)C1NC(=NC=1C1C=C2N=CC=NC2=CC=1)C(C)(C)C

化学属性

Mol. FormulaC21H21N5
Mol. Weight343.42

别名和识别编码

Chemical Name6-(2-(Tert-Butyl)-5-(6-Methylpyridin-2-Yl)-1H-Imidazol-4-Yl)Quinoxaline
CAS Number356559-20-1
Synonym 6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline 6-[2-tert-butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline SB-525334
MDL NumberMFCD11045307
PubChem Substance ID329824610
Chemical Name Translation6-(2-(叔丁基)-5-(6-甲基吡啶-2-基)-1H-咪唑-4-基)喹喔啉
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分类

  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, GlaxoSmithKline, Kinase/Phosphatase Biology, S, Tyrosine Kinase-Like Biology, Tyrosine Kinase-Like Inhibitors
  • Heterocycles
  • {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Diversification Ready Pharma-Developed Compounds, GlaxoSmithKline, Kinase/Phosphatase Biology, S, Tyrosine Kinase-Like Biology, Tyrosine Kinase-Like Inhibitors, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
  • Amines

产品应用

  • SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGF?-receptor kinase inhibitor with IC50 = 14.3 nM.

相关文献及参考

  • Arcot, S., et al.: Biochem. Pharmacol., 46, 1086

安全信息

GHS Symbol
Precautionary statements
  • P301+P310
  • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
  • P305+P351+P338
Hazard statements
  • H413 Maycauselonglastingharmfuleffectstoaquaticlife 可能对水生生物造成长期持续有害影响。
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H301 Toxic if swallowed 吞食有毒
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany3
Signal word Danger
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Safety Statements
  • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
Hazard Codes Xn
Risk Statements
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
  • R22 Harmful if swallowed 吞咽有害

系列性分类

  1. Life Science 生命科学
  2. Cell Biology 细胞生物学
  3. Cell Signaling and Neuroscience - Cell Biology
  4. Approved Therapeutics/Drug Candidates - Cell Signaling and Neuroscience
  5. GlaxoSmithKline - Approved Therapeutics/Drug Candidates

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