(R)-N-((R)-1-(4-((1H-1,2,4-Triazol-1-Yl)Methyl)-4-Cyclohexylpiperidin-1-Yl)-3-(4-Chlorophenyl)-1-Oxopropan-2-Yl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide (R)-N-((R)-1-(4-((1H-1,2,4-三唑-1-基)甲基)-4-环己基哌啶-1-基)-3-(4-氯苯基)-1-氧代丙-2-基)-1,2,3,4-四氢异喹啉-3-甲酰胺
CAS 312637-48-2 MFCD09970598
化学结构图
SMILES: O=C(N[C@H](CC1=CC=C(Cl)C=C1)C(=O)N1CCC(CN2C=NC=N2)(CC1)C1CCCCC1)[C@H]1CC2C=CC=CC=2CN1
化学属性
| Mol. Formula | C33H41ClN6O2 |
|---|---|
| Mol. Weight | 589.18 |
别名和识别编码
| Chemical Name | (R)-N-((R)-1-(4-((1H-1,2,4-Triazol-1-Yl)Methyl)-4-Cyclohexylpiperidin-1-Yl)-3-(4-Chlorophenyl)-1-Oxopropan-2-Yl)-1,2,3,4-Tetrahydroisoquinoline-3-Carboxamide |
|---|---|
| Chemical Name Translation | (R)-N-((R)-1-(4-((1H-1,2,4-三唑-1-基)甲基)-4-环己基哌啶-1-基)-3-(4-氯苯基)-1-氧代丙-2-基)-1,2,3,4-四氢异喹啉-3-甲酰胺 |
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相关文献及参考
- [2]. Huang H, et al. A small molecule agonist THIQ as a novel pharmacoperone for intracellularly retainedmelanocortin-4 receptor mutants. Int J Biol Sci. 2014 Jul 20;10(8):817-24.
- [1]. Sebhat IK, et al. Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist. J Med Chem. 2002 Oct 10;45(21):4589-93.
- [1]. Sebhat IK, et al. Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist. J Med Chem. 2002 Oct 10;45(21):4589-93.
- [2]. Huang H, et al. A small molecule agonist THIQ as a novel pharmacoperone for intracellularly retainedmelanocortin-4 receptor mutants. Int J Biol Sc
