Ticagrelor 替卡格雷
CAS 274693-27-5 MFCD09954148
化学结构图
SMILES: CCCSC1N=C(N[C@@H]2C[C@H]2C2=CC(F)=C(F)C=C2)C2N=NN([C@@H]3C[C@H](OCCO)[C@@H](O)[C@H]3O)C=2N=1 |&1:8,10,23,25,30,32|
化学属性
| Mol. Formula | C23H28F2N6O4S |
|---|---|
| Mol. Weight | 523 |
| Melting Point | 149-154 |
别名和识别编码
| Chemical Name | Ticagrelor |
|---|---|
| CAS Number | 274693-27-5 |
| Synonym | (1S,2S,3R,5S)- |
| Chemical Name Translation | 替卡格雷 |
| LabNetwork Molecule ID | LN00192701 |
| MDL Number |
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分类
- Aromatics
- Heterocycles
- Pharmaceuticals
- Intermediates & Fine Chemicals
- Sulfur & Selenium Compounds
产品应用
- Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndrom
相关文献及参考
- [2]. Gebremeskel S, et al. The reversible P2Y12 inhibitor ticagrelor inhibits metastasis and improves survival in mouse models of cancer. Int J Cancer. 2015 Jan 1;136(1):234-40.
- [3]. Sugidachi A, et al. A comparison of the pharmacological profiles of prasugrel and ticagrelor assessed by platelet aggregation, thrombus formation and haemostasis in rats. Br J Pharmacol. 2013 May;169(1):82-9.
- Matetzky, S., et al.: Circulation, 109, 3171
- [1]. Aungraheeta R, et al. Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 2016 Dec 8;128(23):2717-2728.
- [1]. Aungraheeta R, et al. Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor. Blood. 2016 Dec 8;128(23):2717-2728.
- [2]. Gebremeskel S, et al. The reversible P2Y12 inhibitor ticagrelor inhibits metastasis and improves survival in mouse models of cancer. Int J Cancer.
安全信息
GHS Symbol
