Prinaberel 普林贝瑞
CAS 524684-52-4 MFCD09954141
化学结构图
SMILES: C=Cc1cc(O)cc2nc(-c3ccc(O)c(F)c3)oc12
化学属性
| Mol. Formula | C15H10FNO3 |
|---|---|
| Mol. Weight | 271.24 |
别名和识别编码
| Chemical Name | Prinaberel |
|---|---|
| CAS Number | 524684-52-4 |
| Synonym | 2-(3-Fluoro-4- 2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol Prinaberel WAY-202041 2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3-benzoxazol-5-ol; WAY-202041; Prinaberel 7-Ethenyl-2-(3-fluoro-4-hydroxyphenyl)-5-benzoxazolol ERB 041 ERB-041 ERB041 |
| MDL Number | MFCD09954141 |
| PubChem Substance ID | 656954 |
| Chemical Name Translation | 普林贝瑞 |
| InChI | InChI=1S/C15H10FNO3/c1-2-8-5-10(18)7-12-14(8)20-15(17-12)9-3-4-13(19)11(16)6-9/h2-7,18-19H,1H2 |
| LabNetwork Molecule ID | LN01297611 |
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资金保障
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分类
- Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones, E, Estrogen, Hormones, Pfizer Compounds, Steroid Hormones
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Cytokines, Growth Factors and Hormones, Diversification Ready Pharma-Developed Compounds, E, Estrogen, Hormones, Pfizer Compounds, Steroid Hormones, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- ERB 041 is a potent ER? agonist; displays >200-fold selectivity for ER? over ER? (IC50 values are 5 and 1216 nM for human ER? and ER?; 3.1 and 620 nM for rat ER? and ER?; and 3.7 and 750 nM for mouse
相关文献及参考
- Harris, et al.: Endocrinology, 144. 4241 (2003); Malamas, et al.: J. Med. Chem., 47, 5021 (2004); Cvoro, et al.: J. Immunol., 180, 630 (2008),
- Catley MC, Birrell MA, Hardaker EL, de Alba J, Farrow S, Haj-Yahia S, Belvisi MG.,, "Estrogen receptor beta: expression profile and possible anti-inflammatory role in disease." J. Pharmacol. Exp. Ther. 1 , 83-8, (2008)
- Paruthiyil S, Cvoro A, Zhao X, Wu Z, Sui Y, Staub RE, Baggett S, Herber CB, Griffin C, et. al., Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists. PLoS ONE 7 , (2009)
- Cvoro A, Tatomer D, Tee MK, Zogovic T, Harris HA, Leitman DC., "Selective estrogen receptor-beta agonists repress transcription of proinflammatory genes." J. Immunol. 1 , 630-6, (2008) 摘要
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P301+P312
- P305+P351+P338
- P330 Rinse mouth. 漱口
- P337+P313
- P501 Dispose of contents/container to..… 处理内容物/容器.....
- H302 Harmful if swallowed 吞食有害
- H319 Causes serious eye irritation 严重刺激眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36 Irritating to eyes 刺激眼睛
- R22 Harmful if swallowed 吞咽有害
