Canertinib dihydrochloride N-[4-[(3-氯-4-氟苯基)氨基]-7-(3-吗啉-4-基丙氧基)喹唑啉-6-基]-2-丙烯酰胺二盐酸盐
CAS 289499-45-2 MFCD09954112
化学结构图
SMILES: Cl.Cl.C=CC(=O)NC1=CC2C(NC3C=C(Cl)C(F)=CC=3)=NC=NC=2C=C1OCCCN1CCOCC1
化学属性
| Mol. Formula | C24H25ClFN5O3· 2HCl |
|---|---|
| Mol. Weight | 558.86 |
别名和识别编码
| Chemical Name | Canertinib dihydrochloride |
|---|---|
| Synonym | CI-1033 Canertinib dihydrochloride Canertinib dihydrochloride N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride PD183805 N-[4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]acrylamide dihydrochloride N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide dihydrochloride PD183805 |
| MDL Number | MFCD09954112 |
| CAS Number | 289499-45-2 |
| PubChem Substance ID | 329775143 |
| Chemical Name Translation | N-[4-[(3-氯-4-氟苯基)氨基]-7-(3-吗啉-4-基丙氧基)喹唑啉-6-基]-2-丙烯酰胺二盐酸盐 |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index,
- Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Epidermal Growth Factor Receptor & ErbII (EGFR/ErbB-2), Kinase/Phosphatase Biology, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors
- {SNA} Bioactive Small Molecule Alphabetical Index, CI-CZ, Epidermal Growth Factor Receptor & ErbII (EGFR/ErbB-2), Kinase/Phosphatase Biology, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors,
- {SNA} Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Epidermal Growth Factor Receptor & ErbII (EGFR/ErbB-2), Kinase/Phosphatase Biology, Receptor Tyrosine Kinase Biology, Receptor Tyrosine Kinase Inhibitors
- {SNA}
相关文献及参考
- Bahrami, J., et al Gastroenterology , (2010)
- Sonne-Hansen, K., et al Breast Cancer Res. Treat. , (2009)
- Garland, LL., et al Clin. Cancer Res. 12 , 4274-4282, (2006)
- Merck 14 ,1744
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
