Lopinavir Metabolite M-1
CAS 192725-39-6 MFCD09840842
化学结构图
SMILES: CC(C)[C@@H](C(=O)N[C@H](C[C@H](O)[C@H](CC1=CC=CC=C1)NC(=O)OCC1=C(C)C=CC=C1C)CC1=CC=CC=C1)N1CCC(=O)NC1=O
化学属性
| Mol. Formula | C37H46N4O6 |
|---|---|
| Mol. Weight | 642.78 |
别名和识别编码
| Chemical Name | Lopinavir Metabolite M-1 |
|---|---|
| CAS Number | 192725-39-6 |
| Synonym | (?S)-N-[(1S,3S,4S)-4-[[(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-?-(1-methylethyl)-2,4-dioxo-1(2H)-pyrimidineacetami- |
| Chemical Name Translation |
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资金保障
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分类
- Metabolites & Impurities
- Non-nucleoside Reverse Transcriptase
- Pharmaceuticals
- Intermediates & Fine Chemicals,
产品应用
- A major metabolite of Lopinavir (L469480) .
相关文献及参考
- [2]. Kumar GN, et, al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug; 27(8): 902-8.
- Molla, A., et al.: J. Virology, 250, 255
- [1]. Sham HL, et, al. Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4; 11(11): 1351-3.
- [1]. Sham HL, et, al. Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4; 11(11): 1351-3.
- [2]. Kumar GN, et, al. Potent inhibition of the cytochrome P-450 3A-mediated human liver microsomal metabolism of a novel HIV protease inhibitor by ritonavir: A positive drug-drug interaction. Drug Metab Dispos. 1999 Aug; 27(8): 902-8.
