4-(2-Methyl-1H-Imidazol-1-Yl)-2,2-Diphenylbutanamide 4-(2-甲基-1H-咪唑-1-基)-2,2-二苯基丁酰胺
CAS 170105-16-5 MFCD09833703
化学结构图
SMILES: CC1=NC=CN1CCC(C(N)=O)(C1C=CC=CC=1)C1C=CC=CC=1
化学属性
| Mol. Formula | C20H21N3O |
|---|---|
| Mol. Weight | 319.40 |
别名和识别编码
| Chemical Name | 4-(2-Methyl-1H-Imidazol-1-Yl)-2,2-Diphenylbutanamide |
|---|---|
| CAS Number | 170105-16-5 |
| Synonym | 2-Methyl-?,?-diphenyl-1H-imidazole-1-butanamide 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide 4-(2-Methyl-1-imidazolyl)-2,2- |
| MDL Number | MFCD09833703 |
| Chemical Name Translation | 4-(2-甲基-1H-咪唑-1-基)-2,2-二苯基丁酰胺 |
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资金保障
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分类
- Pharmaceuticals
- Amines
- Heterocycles
- Intermediates & Fine Chemicals
- {SNA} Building Blocks, C9 to C30+, Chemical Synthesis, Heterocyclic Building Blocks, Imidazoles
产品应用
- A novel therapeutic agent for overactive bladder with antimuscarinic activity, on mediator release from urothelium and detrusor overactivity induced by cerebral infarction. A muscarinic antagonist.
相关文献及参考
- [2]. Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1095-102.
- Andersson, K., et al.: Eur. Urol., 43, 1 (2003),
- Kullmann, F., et al.: J. Neurosci., 28, 1977 (2008),
- Wang, X., et al.: Biomed. Res. 29, 105 (2008),
- [1]. Miyachi H, et al. Synthesis and antimuscarinic activity of a series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents. Bioorg Med Chem. 1999 Jun;7(6):1151-61.
- [1]. Miyachi H, et al. Synthesis and antimuscarinic activity of a series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents. Bioorg Med Chem. 1999 Jun;7(6):1151-61.
- [2]. Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1095-102.
