4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline 4-氯-6,7-二(2-甲氧基乙氧基)喹唑啉
CAS 183322-18-1 MFCD09751265
化学结构图
SMILES: COCCOC1=CC2C(Cl)=NC=NC=2C=C1OCCOC
化学属性
| Mol. Formula | C14H17ClN2O4 |
|---|---|
| Mol. Weight | 313 |
| Melting Point | 99.0 to 104.0 deg-C |
别名和识别编码
| Chemical Name | 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline |
|---|---|
| CAS Number | 183322-18-1 |
| Alfabeta Name | CHLOROBISMETHOXYETHOXYQUINAZOLINE 4672()----, |
| MDL Number | MFCD09751265 |
| Synonym | 4-Chloro-6,7-bis(2-methoxyethoxy)-quinazoline 4-Chloro-6,7-bis(2-methoxyethoxy)-quinazoline PF-508367 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline 4-Chloro-6,7-di(2-methoxyethoxy) CP-335963 PF-508367 |
| Chemical Name Translation | 4-氯-6,7-二(2-甲氧基乙氧基)喹唑啉 |
| LabNetwork Molecule ID | LN00171912 |
| PubChem Substance ID | 329823700 |
| Reaxys-RN | 8781189 |
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分类
- Approved Therapeutics/Drug Candidates, Bioactive Small Molecules,
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Pfizer Compounds, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
- {SNA} Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, CI-CZ, Diversification Ready Pharma-Developed Compounds, Kinase/Phosphatase Biology, Pfizer Compounds, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和神经科学,
产品应用
- CP-335963 is an aurora 2 kinase inhibitor, PDGF inhibitor, useful in the treatment of cancer.
相关文献及参考
- Ban, H.S., et al., Allene as an alternative functional group for drug design: effect of C-C multiple bonds conjugated with quinazolines on the inhibition of EGFR tyrosine kinase. ChemMedChem 3 , 1094-1103, (2008)
- Bedi, P., et al.: Bioorg. Med. Chem. Lett., 14, 5211 (2004),
- Lueth, A., and Loewe, W., A new class of epidermal growth factor receptor tyrosine kinase inhibitors. Eur. J. Med. Chem. 43 , 1478-1488, (2008)
- Mosaad, S., et al.: J. Biol. Sci., 4, 504, (2004),
- Zheng, Y., et al.: Chem. Biol. Drug Des., 76, 285 (2010),
安全信息
GHS Symbol
- P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P302+P352+P332+P313+P362+P364
- P305+P351+P338
- P305+P351+P338+P337+P313
- H302 Harmful if swallowed 吞食有害
- H315 Causes skin irritation 会刺激皮肤
- H318 Causes serious eye damage 严重伤害眼睛
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S39 Wear eye/face protection 戴眼睛/面孔保护装置；
- R22 Harmful if swallowed 吞咽有害
- R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
