N-(3-((4-((3-(Trifluoromethyl)Phenyl)Amino)Pyrimidin-2-Yl)Amino)Phenyl)Cyclopropanecarboxamide N-(3-((4-((3-(三氟甲基)苯基)氨基)嘧啶-2-基)氨基)苯基)环丙烷甲酰胺
CAS 879127-16-9 MFCD09265250
化学结构图
SMILES: O=C(NC1C=C(C=CC=1)NC1=NC(=CC=N1)NC1C=C(C=CC=1)C(F)(F)F)C1CC1
化学属性
| Mol. Formula | C21H18F3N5O |
|---|---|
| Mol. Weight | 413.40 |
别名和识别编码
| Chemical Name | N-(3-((4-((3-(Trifluoromethyl)Phenyl)Amino)Pyrimidin-2-Yl)Amino)Phenyl)Cyclopropanecarboxamide |
|---|---|
| Synonym | Aurora Kinase Inhibitor III Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide |
| MDL Number | MFCD09265250 |
| PubChem Substance ID | 24724434 |
| CAS Number | 879127-16-9 |
| Chemical Name Translation | N-(3-((4-((3-(三氟甲基)苯基)氨基)嘧啶-2-基)氨基)苯基)环丙烷甲酰胺 |
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分类
- Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
- {SNA} Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
- {SNA} Bioactive Small Molecule Alphabetical Index, CI-CZ, Kinase/Phosphatase Biology, Protein Kinases (PK), Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors, 生物活性小分子, 细胞信号转导和
相关文献及参考
- Zhang, Q., et al., Discovery of EGFR selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library J. Am. Chem. Soc. 128 , 2182-2183, (2006) 摘要
- Pascreau, G., et al., Phosphorylation Of P53 Is Regulated By TPX2-Aurora A In Xenopus Oocytes. J. Thorac. Cardiovasc. Surg. 284 , 5497-505, (2009) 摘要
- Singh, M.K., et al., Enhanced Genetic Instability And Dasatinib Sensitivity In Mammary Tumor Cells Lacking NEDD9. Cancer Res. 70 , 8907-16, (2010) 摘要
- Astsaturov, I., et al., Synthetic Lethal Screen Of An EGFR-centered Network To Improve Targeted Therapies. Science Signaling 3 , ra67, (2010) 摘要
