7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one 7-氯-5-(2-氯苯基)-1,5-二氢苯并[e][1,4]硫氮杂卓-2(3H)-酮
CAS 75450-34-9 MFCD09055422
化学结构图
SMILES: O=C1CSC(C2=CC(Cl)=CC=C2N1)C1C=CC=CC=1Cl
化学属性
| Mol. Formula | C15H11Cl2NOS |
|---|---|
| Mol. Weight | 324.22 |
别名和识别编码
| Chemical Name | 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one |
|---|---|
| Synonym | 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one |
| MDL Number | MFCD09055422 |
| PubChem Substance ID | 329775189 |
| Chemical Name Translation | 7-氯-5-(2-氯苯基)-1,5-二氢苯并[e][1,4]硫氮杂卓-2(3H)-酮 |
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分类
- {SNA} Bioactive Small Molecule Alphabetical Index, C-CH, Ion Channels, Ion Pump Inhibitors, Monovalent Ion Channels, Voltage-gated Ion Channels, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
- Cell Biology, Cell Signaling and Neuroscience, Ion Channels, Ion Pump Inhibitors, Monovalent Ion Channels, Voltage-gated Ion Channels
相关文献及参考
- 1. Neumann, J.T., et al., CGP-37157 inhibits the sarcoplasmic reticulum Ca 2+ ATPase and activates ryanodine receptor channels in striated muscle Mol. Pharmacol. 79 , 141-147, (2011)
- Neumann, J.T., et al., CGP-37157 inhibits the sarcoplasmic reticulum Ca 2+ ATPase and activates ryanodine receptor channels in striated Mol. Pharmacol. 79 , 141-147, (2011) 摘要
- Palty, R., et al., NCLX is an essential component of mitochondrial Na+/Ca2+ exchange. Proc. Natl. Acad. Sci. U. S. A. 107 , 436-441, (2010) 摘要
- Chalmers, S., and McCarron, J.G., Inhibition of mitochondrial calcium uptake rather than efflux impedes calcium release by inositol-1,4,5-trisphosphate-sensitive receptors. Cell Calcium 46 , 107-113, (2009) 摘要
- Czyz, A., and Kiedrowski, L., Inhibition of plasmalemmal Na+/Ca2+ exhange by mitochondrial Na+/Ca2+ exhange inhibitor 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one (CGP-37157) in cerebellar granule cells. Biochem. Pharmacol. 66 , 2409-2411, (2003)
安全信息
GHS Symbol
- P273 Avoid release to the environment. 避免释放到环境中。
- H400 Verytoxictoaquaticlife 对水生生物毒性非常大。
- H302 Harmful if swallowed 吞食有害
- S61 Avoid release to the environment. Refer to special instructions/safety data sheet 避免释放到环境中，参考特别指示/安全收据说明书；
- R50 Very toxic to aquatic organisms 对水生生物极毒
- R22 Harmful if swallowed 吞咽有害
