6-Methyl-1’-(2-(5-Methyl-2-Phenyloxazol-4-Yl)Ethyl)Spiro[Benzo[D][1,3]Oxazine-4,4’-Piperidin]-2(1H)-One 6-甲基-1,1’-[2-(5-甲基-2-苯基-4-恶唑基)乙基]-螺[4H-3-1,1-苯并恶嗪-4,4’-哌啶]-2(1H)-酮
CAS 300816-15-3 MFCD09038564
化学结构图
SMILES: Cc1ccc2c(c1)C1(CCN(CCc3nc(-c4ccccc4)oc3C)CC1)OC(=O)N2
化学属性
| Mol. Formula | C25H27N3O3 |
|---|---|
| Mol. Weight | 417.506 |
别名和识别编码
| Chemical Name | 6-Methyl-1’-(2-(5-Methyl-2-Phenyloxazol-4-Yl)Ethyl)Spiro[Benzo[D][1,3]Oxazine-4,4’-Piperidin]-2(1H)-One |
|---|---|
| Chemical Name Translation | 6-甲基-1,1’-[2-(5-甲基-2-苯基-4-恶唑基)乙基]-螺[4H-3-1,1-苯并恶嗪-4,4’-哌啶]-2(1H)-酮 |
| PubChem Substance ID | 9953769 |
| InChI | InChI=1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29) |
| LabNetwork Molecule ID | LN00189860 |
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相关文献及参考
- [2]. Yang, Dong., et al. Roles of CC chemokine receptors (CCRs) on lipopolysaccharide-induced acute lung injury. Respiratory Physiology & Neurobiology (2010), 170(3), 253-259.
- [3]. Kitagawa, Kiyoki., et al. Blockade of CCR2 ameliorates progressive fibrosis in kidney. American Journal of Pathology (2004), 165(1), 237-246.
- [4]. Tominaga T, et al. Blocking mast cell-mediated type I hypersensitivity in experimental allergic conjunctivitis by monocyte chemoattractant protein-1/CCR2. Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5181-8.
- [5]. Mirzadegan T, et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle. J Biol Chem. 2000 Aug 18;275(33):25562-71.
- [1]. Baamonde, Ana., et al. Involvement of glutamate NMDA and AMPA receptors, glial cells and IL-1β in the spinal hyperalgesia evoked by the chemokine CCL2 in mice. Neuroscience Letters
