1,3-DIHYDRO-1-(1-((4-(6-PHENYL-1H-IMIDAZO[4,5-G]QUINOXALIN-7-YL)PHENYL)METHYL)-4-PIPERIDINYL)-2H-BENZIMIDAZOL-2-ONE TRIFLUOROACETATE SALT HYDRATE
CAS N/A MFCD08705407
化学结构图
SMILES: O.OC(=O)C(F)(F)F.O=C1NC2C=CC=CC=2N1C1CCN(CC2C=CC(=CC=2)C2=NC3C=C4N=CNC4=CC=3N=C2C2C=CC=CC=2)CC1
化学属性
| Mol. Formula | C34H29N7O · xC2HF3O2· yH2O |
|---|---|
| Mol. Weight | 551.64 (anhydrous free base basis) |
别名和识别编码
| Chemical Name | Akt1/2 kinase inhibitor |
|---|---|
| Synonym | 1,3-Dihydro-1-(1-((4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl)methyl)-4-piperidinyl)-2H-benzimidazol-2-one trifluoroacetate salt hydrate Akt Inhibitor VIII trifluoroacetate salt hydrate Akti-1/2 trifluoroacetate salt hydrate |
| MDL Number | MFCD08705407 |
| PubChem Substance ID | 24891133 |
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分类
- {SA} A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Merck, Protein Kinase B (Akt/PKB), Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
- A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Kinase/Phosphatase Biology, Merck, Protein Kinase B (Akt/PKB), Protein Kinase Inhibitors, Serine/Threonine Kinase Biology, Serine/Threonine Kinase Inhibitors
- {SNA} A-AM, Approved Therapeutics/Drug Candidates,
相关文献及参考
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- Li, S., et al., From The Cover: Bifurcation Of Insulin Signaling Pathway In Rat Liver: MTORC1 Required For Stimulation Of Lipogenesis, But Not Inhibition Of Gluconeogenesis Proc. Natl. Acad. Sci. U. S. A. 107 , 3441-3446, (2010) 摘要
- Li, S., et al., Bifurcation Of Insulin Signaling Pathway In Rat Liver: MTORC1 Required For Stimulation Of Lipogenesis, But Not Inhibition Of Gluconeogenesis. Proc. Natl. Acad. Sci. U. S. A. 107 , 3441-6, (2010) 摘要
- Desplat, V., et al., Synthesis And Evaluation Of The Antiproliferative Activity Of Novel Pyrrolo[1,2-a]quinoxaline Derivatives, Potential Inhibitors Of Akt Kinase. Part II. J. Enzyme Inhib. Med. Chem. 25 , 204-15, (2010) 摘要
- Amanso, A.M., et al., Proteasome Inhibition Represses Unfolded Protein Response And Nox4, Sensitizing Vascular Cells To Endoplasmic Reticulum Stress-induced Death. PLoS ONE 6 , e14591, (2011) 摘要
- Zhang, X. and T.A. Vik, Growth factor stimulation of hematopoietic cells leads to membrane translocation of AKT1 protein kinase Leuk. Res. 21 , 849-856, (1997)
- Zhao, Z., et al., Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors Bioorg. Med. Chem. Lett. 15 , 905-909, (2005)
- Ajmani, S., et al., A comprehensive structure–activity analysis of protein kinase B-α (Akt1) inhibitors J. Mol. Graph. Model. 28 , 683-694, (2010)
- Zhao, Z., et al., Discovery of 2,3,5-trisubstituted pyridine derivatives as potent Akt1 and Akt2 dual inhibitors. Bioorg. Med. Chem. Lett. 15 , 905-909, (2005)
- Barnett, S.F., et al, Identification and characterization of pleckstrin-h
