CAS 656820-32-5 MFCD07784513-Reversine N6-环己基-N2-(4-吗啉苯基)-9H-嘌呤-2,6-二胺 TAO{mole}

SMILES: c1nc2nc(Nc3ccc(N4CCOCC4)cc3)nc(NC3CCCCC3)c2[nH]1

Chemical Name	Reversine
Synonym	2-(4-Morpholinoanilino)-6-cyclohexylaminopurine Reversine Reversine.
MDL Number	MFCD07784513
PubChem Substance ID	24724590
CAS Number	656820-32-5
Chemical Name Translation	N6-环己基-N2-(4-吗啉苯基)-9H-嘌呤-2,6-二胺
Formula	C21H27N7O
IUPAC Name	N6-cyclohexyl-N2-(4-morpholinophenyl)-7H-purine-2,6-diamine
InChIKey	ZFLJHSQHILSNCM-UHFFFAOYSA-N
InChI	InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)
Canonical SMILES	C12=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC(NC5CCCCC5)=C1NC=N2

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Reversine is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation. Reversine is also a novel Aurora kinases inhibitor that inhibits colony formation of human acute myeloid leukemia cells. Reversine inhibits the phosphorylation of histone H3, a direct downstream target of Aurora kinases. Similarly to the Aurora kinase inhibitor VX-680, reversine inhibited colony formation of leukemic cells from patients with acute myeloid leukemia but was significantly less toxic than VX-680 on cells from healthy donors.

WGK Germany3

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Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes Xn

Risk Statements

Storage condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

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