Eplerenone 依普利酮
CAS 107724-20-9 MFCD07783647
化学结构图
SMILES: COC(=O)[C@@H]1CC2=CC(=O)CC[C@]2(C)[C@@]23O[C@@H]2C[C@@]2(C)[C@@H](CC[C@@]42CCC(=O)O4)[C@@H]31
化学属性
| Mol. Formula | C24H30O6 |
|---|---|
| Mol. Weight | 414.50 |
别名和识别编码
| Chemical Name | Eplerenone |
|---|---|
| CAS Number | 107724-20-9 |
| Synonym | 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, methyl ester 9,11α-Epoxy-17-hydroxy-3-oxo-17α-pregn-4-ene-7α,21-dicarboxylic acid γ-Lactone methyl ester CGP 30083 Epoxymexrenone Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)- Inspra Cgp 30083 (7?,11?,17?)-9,11-Epoxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicarboxylic Acid Eplerenone [USAN] SC-66110 9,11-Epoxy-17-hydroxy-3-oxo-17-pregn-4-ene-7,21-dicarboxylic acid -Lactone methyl ester |
| Reaxys-RN | 7892318 |
| MDL Number | MFCD07783647 |
| Merck Number | 3625 |
| Chemical Name Translation | 依普利酮 |
| PubChem Substance ID | 160870987 |
| Beilstein Registry Number | 7892318 |
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分类
- Approved Therapeutics/Drug Candidates, Cell Biology, Cell Signaling and Neuroscience, Corticosteroid, Cytokines, Growth Factors and Hormones, Hormones, Pfizer Compounds, Steroid Hormones
产品应用
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相关文献及参考
- [2]. Marvin J Meyers, et al. Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy. J Med Chem. 2010 Aug 26;53(16):5979-6002.
- Burgess, E., et al.: Expert. Opin. Pharmacother., 5, 2573 (2004),
- Delyani, J.A., et al.: Cardiovasc. Drug Rev., 19, 185 (2001),
- Dietz J.D., et al., A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity. Hypertension 51 , 742-8, (2008) 摘要
- Imanishi T., et al., Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability. Hypertension 51 , 734-41, (2008) 摘要
- Merck 14 ,3625
- [1]. Dhillon, S., Eplerenone: a review of its use in patients with chronic systolic heart failure and mild symptoms. Drugs, 2013. 73(13): p. 1451-6
安全信息
GHS Symbol
