(3S)-3-(4-AMINO-1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PIPERIDINE-2,6-DIONE 来那度胺
CAS 191732-72-6 MFCD07772307
化学结构图
SMILES: Nc1cccc2c1CN(C1CCC(=O)NC1=O)C2=O
化学属性
| Mol. Formula | C13H13N3O3 |
|---|---|
| Mol. Weight | 259 |
| Melting Point | 269-271° |
| Appearance | White solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | (3S)-3-(4-AMINO-1-OXO-1,3-DIHYDRO-2H-ISOINDOL-2-YL)PIPERIDINE-2,6-DIONE |
|---|---|
| Synonym | 3-(7-Amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione CC5013; CC-5013; CC 5013; IMiD1; Lenalidomide; US brand name: Revlimid. |
| Chemical Name Translation | 来那度胺 |
| CAS Number | 191732-72-6 |
| Alfabeta Name | AMINOOXODIHYDROISOINDOLYLPIPERIDINEDIONE H341132226()------------,, |
| MDL Number | MFCD07772307 |
| Formula | C13H13N3O3 |
| IUPAC Name | 3-(4-amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione |
| InChIKey | GOTYRUGSSMKFNF-UHFFFAOYSA-N |
| InChI | InChI=1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18) |
| Canonical SMILES | O=C(C(N(CC1=C2C=CC=C1N)C2=O)CC3)NC3=O |
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信息真实价格透明
资金保障
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产品应用
- Lenalidomide, also known as CC-5013, is the thalidomide analog with potential antineoplastic activity. Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells. Lenalidomide is an approved drug.
安全信息
GHS Symbol
- S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套；
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
