1,1’-(Butane-1,4-Diyl)Bis(3-(3-Isothiocyanatophenyl)Thiourea) 1,1’-(丁烷-1,4-二基)双(3-(3-异硫氰酸苯)硫脲)
CAS 711019-86-2 MFCD07370141
化学结构图
SMILES: S=C(NC1=CC(=CC=C1)N=C=S)NCCCCNC(=S)NC1=CC(=CC=C1)N=C=S
化学属性
| Mol. Formula | C20H20N6S4 |
|---|---|
| Mol. Weight | 472.67 |
别名和识别编码
| Chemical Name | 1,1’-(Butane-1,4-Diyl)Bis(3-(3-Isothiocyanatophenyl)Thiourea) |
|---|---|
| Synonym | 1,4-Di[3-(3-isothiocyanatophenyl)thioureido]butane MRS 2578 |
| PubChem Substance ID | 24724530 |
| MDL Number | MFCD07370141 |
| CAS Number | 711019-86-2 |
| Chemical Name Translation | 1,1’-(丁烷-1,4-二基)双(3-(3-异硫氰酸苯)硫脲) |
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分类
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, G Protein Function, G Proteins and Cyclic Nucleotides, M, Post-translational Modification
- {SNA} Bioactive Small Molecule Alphabetical Index, G Protein Function, G Proteins and Cyclic Nucleotides, M, Post-translational Modification, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
相关文献及参考
- [2]. Nishida M, et al. P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiacfibrosis. EMBO J. 2008 Dec 3;27(23):3104-15.
- [3]. Riegel AK, et al. Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood, 2011, 117(8), 2548-2555.
- [4]. Vieira RP, et al. Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation. Am J Respir Crit Care Med, 2011, 184(2), 215-223.
- [1]. Mamedova LK, et al. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol, 2004, 67(9), 1763-1770.
- [1]. Mamedova LK, et al. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol, 2004, 67(9), 1763-1770.
- [2]. Nishida M, et al. P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-indu
安全信息
GHS Symbol
- H312+H332
- H315 Causes skin irritation 会刺激皮肤
- H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled 吸入可能导致过敏或哮喘症状或呼吸困难
- H301 Toxic if swallowed 吞食有毒
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- H319 Causes serious eye irritation 严重刺激眼睛
- H332 Harmful if inhaled 吸入有害
- H312 Harmful in contact with skin 皮肤接触有害
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P301+P310+P330
- P284 Wear respiratory protection.? 佩戴呼吸保护装置。
- P304+P340+P312
- P342+P311
- P302+P352+P312
- P301+P310
- P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
- P305+P351+P338
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
- S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
- S22 Do not breathe dust 不要吸入粉尘；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
- R42 May cause sensitisation by inhalation 吸入会产生过敏反应
- R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
