SM-19712
CAS 194542-56-8 MFCD06798351
化学结构图
SMILES: CC1=NN(C(NC(=O)N([Na])S(=O)(=O)C2C=CC(Cl)=CC=2)=C1C#N)C1C=CC=CC=1
化学属性
| Mol. Formula | C18H13ClN5NaO3S · xH2O |
|---|---|
| Mol. Weight | 437.84 (anhydrous basis) |
别名和识别编码
| Chemical Name | SM-19712 hydrate |
|---|---|
| Synonym | 4-Chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino]carbonyl]benzenesulfonamide sodium salt hydrate |
| CAS Number | 194542-56-8 (anhydrous) |
| PubChem Substance ID | 329824532 |
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分类
- Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, D to K, Endothelin converting enzyme, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, Enzymes, Inhibitors, and Substrates, S
- {SNA} Bioactive Small Molecule Alphabetical Index, D to K, Endothelin converting enzyme, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme, S, 生化试剂, 生物活性小分子, 细胞生物学, 酶、抑制剂和底物
相关文献及参考
- Matsumura, Y., et al., Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats. Jpn. J. Pharmacol. 84 , 16-21, (2000) 摘要
- Umekawa, K., et al., Pharmacological characeterization of a novel sulfonylureid-pyrazole derivative, SM-19712, a potent nonpeptidic inhibitor of endothelin converting enzyme. Jpn. J. Pharmacol. 84 , 7-15, (2000) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
