Bafilomycin A1 巴佛洛霉素 A1
CAS 88899-55-2 MFCD06795130
化学结构图
SMILES: CC(C)[C@H]1O[C@](O)(C[C@@H](O)[C@@H]1C)[C@@H](C)[C@H](O)[C@H](C)[C@H]1OC(=O)C(=CC(C)=C[C@@H](C)[C@@H](O)[C@@H](C)CC(C)=CC=C[C@@H]1OC)OC |t:23,26,36,38|
化学属性
| Mol. Formula | C35 |
|---|---|
| Mol. Weight | 623 |
别名和识别编码
| Chemical Name | Bafilomycin A1 |
|---|---|
| MDL Number | MFCD06795130 |
| PubChem Substance ID | 24891613 |
| Beilstein Registry Number | 4730700 |
| CAS Number | 88899-55-2 |
| Synonym | Bafilomycin A1 from Streptomyces griseus |
| Chemical Name Translation | 巴佛洛霉素 A1 |
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分类
- {SA} Antibiotics, Antibiotics A to Z, Antibiotics A-F,
- Antibiotics, Antibiotics A to Z, Antibiotics A-F, Antibiotics by Application, Antifungal, Antineoplastic and Immunosuppressive Antibiotics, Autophagy, Autophagy Inhibitors, B, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Chemical Structure Class, Inhibits an Enzyme, Interferes with DNA Synthesis, Ion Channels, Ion Pump Inhibitors, Macrolides, Mechanism of Action, Monovalent Ion Channels, Spectrum of Activity, Voltage-gated Ion Channels
- {SNA} Antibiotics A to Z,
相关文献及参考
- Bowman, E.J., et al. Proc. Natl. Acad. Sci. U. S. A. 85 , 7972, (1988) 摘要
- Umata, T., et al. J. Biol. Chem. 265 , 21940, (1990) 摘要
- Yoshimori, T., et al. J. Biol. Chem. 266 , 17707, (1991) 摘要
- Saurin, A.J., et al. Biochem. J. 313 , 65, (1996) 摘要
- Rainey, M.M., et al., The Antidepressant Sertraline Targets Intracellular Vesiculogenic Membranes In Yeast. Genetics 185 , 1221-33, (2010) 摘要
安全信息
GHS Symbol
- P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
- P305+P351+P338
- H315 Causes skin irritation 会刺激皮肤
- H319 Causes serious eye irritation 严重刺激眼睛
- H335 May cause respiratory irritation 可能导致呼吸道刺激
- S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见；
- S36 Wear suitable protective clothing 穿戴适当的防护服；
- R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
