(5-(1-Benzyl-1H-Indazol-3-Yl)Furan-2-Yl)Methanol (5-(1-苄基-1H-吲唑-3-基)呋喃-2-基)甲醇
CAS 170632-47-0 MFCD06407798
化学结构图
SMILES: OCc1ccc(-c2nn(Cc3ccccc3)c3ccccc23)o1
化学属性
| Mol. Formula | C19H16N2O2 |
|---|---|
| Mol. Weight | 304.34 |
| Appearance | white solid powder |
| Solubility | Soluble in DMSO, not in water |
别名和识别编码
| Chemical Name | (5-(1-Benzyl-1H-Indazol-3-Yl)Furan-2-Yl)Methanol |
|---|---|
| Synonym | 3-(5′-Hydroxymethyl-2′-furyl)-1-benzyl indazole 3-(5'-Hydroxymethyl-2'-furyl)-1-benzyl indazole YC-1 YC1; YC 1; YC-1; Lificiguat. |
| MDL Number | MFCD06407798 |
| PubChem Substance ID | 5712 |
| CAS Number | 170632-47-0 |
| Chemical Name Translation | (5-(1-苄基-1H-吲唑-3-基)呋喃-2-基)甲醇 |
| InChI | InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2 |
| LabNetwork Molecule ID | LN00334125 |
| Formula | C19H16N2O2 |
| IUPAC Name | 5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol |
| InChIKey | OQQVFCKUDYMWGV-UHFFFAOYSA-N |
| Canonical SMILES | OCC1=CC=C(C2=NN(CC3=CC=CC=C3)C4=C2C=CC=C4)O1 |
信息真实价格透明
资金保障
专业采购外包团队在线服务
信息真实价格透明
资金保障
专业采购外包团队在线服务
品牌质保精细包装
现货库存
一流品牌服务
分类
- Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Guanylyl Cyclase Activators, Y
- {SNA} Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Guanylyl Cyclase Activators, Y
- {SNA} Bioactive Small Molecule Alphabetical Index, Cyclic Nucleotide Metabolism, G Proteins and Cyclic Nucleotides, Guanylyl Cyclase Activators, Y, 生物活性小分子, 细胞信号转导和神经科学, 细胞生物学
产品应用
- Lificiguat, also known as YC-1, is a inhibitor of Hypoxia-inducible factor-1alpha (HIF-1alpha). YC-1 is widely used as a potent inhibitor of HIF-1alpha both in vitro and in vivo, and is also being developed as a novel anticancer drug. YC-1 effectively inhibits tumor invasion and metastasis, and imply that YC-1 is worth while to further develop as a multipurpose anticancer drug.
相关文献及参考
- [2]. Kong J, et al. YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Mol Cancer. 2014 Jan 13;13:7.
- [3]. Chang LC, et al. YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. Br J Pharmacol. 2014 Sep;171(17):4010-25.
- [4]. Komsuoglu Celikyurt I, et al. Effects of YC-1 on Learning and Memory Functions of Aged Rats. Med Sci Monit Basic Res. 2014 Aug 21;20:130-7.
- Ko, F, et al., YC-1, a novel activator of platelet guanylate cyclase. Blood 84 , 4226-4233, (1994) 摘要
- Stone, J, et al., Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: Implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide. Chem. Biol. 5 , 255-261, (1998)
- Wu, C, et al., YC-1 inhibited human platelet aggregation through NO-indepen
