CAS 2181-04-6 MFCD05662375-Canrenoic Acid Potassium Salt 坎利酸钾盐 TAO{mole}

Canrenoic Acid Potassium Salt 坎利酸钾盐

CAS 2181-04-6 MFCD05662375

化学结构图

SMILES: CC12CCC(=O)C=C1C=CC1C2CCC2(C)C1CCC2(O)CCC(=O)[O-].[K+]

化学属性

Mol. Formula	C22 H29 K O4
Mol. Weight	396.56
Appearance	powder 微黄白色到黄褐色结晶性粉末。

别名和识别编码

Chemical Name	Canrenoic Acid Potassium Salt
CAS Number	2181-04-6
Synonym	######## 17-HYDROXY-3-OXOPREGNA-4,6-DIENE-21-CARBOXYLIC ACID 17-HYDROXY-3-OXOPREGNA-4,6-DIENE-21-CARBOXYLIC ACID POTASSIUM SALT 17-Hydroxy-3-oxo-17a-pregna-4,6-diene-21-carboxylic acid potassium salt 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid Potassium canrenoate 17-Hydroxy-3-oxopregna-4,6-diene-21-carboxylic acid potassium salt; Canrenoic acid potassium salt 17a-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, monopotassium salt (8CI) 17a-Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, potassium salt (7CI) 4,6-ANDROSTADIEN-17ALPHA-YL-PROPIONIC ACID-17BETA-OL-3-ONE POTASSIUM SALT Aldadiene-kalium Aldadiene-potassium CANRENOIC ACID POTASSIUM SALT CB 8109 Canrenoa Canrenoate Canrenoate (potassium)
MDL Number	MFCD05662375
PubChem Substance ID	23671691
EC Number	218-554-9
Chemical Name Translation	坎利酸钾盐
Wiswesser Line Notation	L E5 B666 OV KU MUTJ A1 E1 FQ F2VQ &-KA-
LabNetwork Molecule ID	LN02126534
InChI	InChI=1S/C22H30O4.K/c1-20-9-5-15(23)13-14(20)3-4-16-17(20)6-10-21(2)18(16)7-11-22(21,26)12-8-19(24)25;/h3-4,13,16-18,26H,5-12H2,1-2H3,(H,24,25);/q;+1/p-1/t16-,17+,18+,20+,21+,22-;/m1./s1
Canonical SMILES	C[C@@]12[C@@](CCC(O[K])=O)(O)CC[C@@]1([H])[C@]3([H])C=CC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O

信息真实价格透明资金保障专业采购外包团队在线服务

品牌质保精细包装现货库存一流品牌服务

产品应用

Canrenoic acid is an aldosterone antagonist. Canrenoic acid is used as an diuretic.

安全信息

RTECSTU3500000

GHS Symbol

WGK Germany3

Hazard statements

H302 Harmful if swallowed 吞食有害

Hazard Codes Xn

Personal Protective Equipment dust mask type N95 (US), Eyeshields, Gloves

Signal word Warning

Safety Statements

S36 Wear suitable protective clothing 穿戴适当的防护服；

Risk Statements

R22 Harmful if swallowed 吞咽有害

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 160 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 11,811,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 140 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
REFERENCE :
   AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans
   Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium)  V.4-   
   1898-  Volume(issue)/page/year: 149,8,1964

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 125 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 11,811,1980

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperiton

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 650 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NIIRDN Drugs in Japan (Ethical Drugs).  (Yakugyo Jiho Co., Ltd., Tokyo,
   Japan)  Volume(issue)/page/year: 6,196,1982

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Rodent - mouse Lymphocyte
DOSE/DURATION           : 150 mg/L
REFERENCE :
   ARTODN Archives of Toxicology.  (Springer-Verlag, Heidelberger Pl. 3, D-1000
   Berlin 33, Fed. Rep. Ger.)  V.32-    1974-  Volume(issue)/page/year:
   61,201,1988

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 560 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
   NICHAS Nichidai Igaku Zasshi.  Nihon University Medical Journal.  (Nihon
   Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan)
   V.1-    1937-  Volume(issue)/page/year: 36,261,1977

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE                    : 420 mg/kg
SEX/DURATION            : female 7-13 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   NICHAS Nichidai Igaku Zasshi.  Nihon University Medical Journal.  (Nihon
   Daigaku Igakkai, 30, Oyaguchi kami-machi, Itabashi-ku, Tokyo 173, Japan)
   V.1-    1937-  Volume(issue)/page/year: 36,261,1977

Storage condition +4°C 2-8°C 4℃ Store at room temperature

其他信息

Sigma Aldrich:2181-04-6(sigmaaldrich)
MOL 文件:2181-04-6.mol
color:light yellow to tan